Fotograaf: Harm Krugers

dhr. dr. H.J. (Harm) Krugers

  • Faculteit der Natuurwetenschappen, Wiskunde en Informatica
  • Bezoekadres
    Science Park A
    Science Park 904  Amsterdam
    Kamernummer: C3.270
  • Postadres:
    Postbus  94232
    1090 GE  Amsterdam
    T: 0205257621


  • Arp, J. M., ter Horst, J. P., Loi, M., den Blaauwen, J., Bangert, E. L., Fernández, G., ... Krugers, H. J. (2016). Blocking glucocorticoid receptors at adolescent age prevents enhanced freezing between repeated cue-exposures after conditioned fear in adult mice raised under chronic early life stress. Neurobiology of Learning and Memory, 133, 30-38. DOI: 10.1016/j.nlm.2016.05.009 [details]
  • Lesuis, S. L., Maurin, H., Borghgraef, P., Lucassen, P. J., Van Leuven, F., & Krugers, H. J. (2016). Positive and negative early life experiences differentially modulate long term survival and amyloid protein levels in a mouse model of Alzheimer’s disease. OncoTarget, 7(26), 39118-39135. DOI: 10.18632/oncotarget.9776 [details] [PDF]
  • Lucassen, P. J., Korosi, A., Krugers, H., & Oomen, C. A. (2016). Early life stress and sex-dependent effects on hippocampal neurogenesis. In G. Fink (Ed.), Handbook of Stress. Amsterdam: Elsvier Publishers. [details]
  • Xiong, H., Cassé, F., Zhou, M., Xiong, Z. Q., Joels, M., Martin, S., & Krugers, H. J. (2016). Interactions between N-Ethylmaleimide-sensitive factor and GluA2 contribute to effects of glucocorticoid hormones on AMPA receptor function in the rodent hippocampus. Hippocampus, 26(7), 848-856. DOI: 10.1002/hipo.22567 [details]
  • Derks, N. A. V., Krugers, H. J., Hoogenraad, C. C., Joëls, M., & Sarabdjitsingh, R. A. (2016). Effects of Early Life Stress on Synaptic Plasticity in the Developing Hippocampus of Male and Female Rats. PLoS One, 11(10), [e0164551]. DOI: 10.1371/journal.pone.0164551 [details] [PDF]
  • Vogel, S., Klumpers, F., Schröder, T. N., Oplaat, K. T., Krugers, H. J., Oitzl, M. S., ... Fernández, G. (2016). Stress Induces a Shift Towards Striatum-Dependent Stimulus-Response Learning via the Mineralocorticoid Receptor. Neuropsychopharmacology. DOI: 10.1038/npp.2016.262 [details]


  • Kanatsou, S., Fearey, B. C., Kuil, L. E., Lucassen, P. J., Harris, A. P., Seckl, J. R., ... Joels, M. (2015). Overexpression of Mineralocorticoid Receptors Partially Prevents Chronic Stress-Induced Reductions in Hippocampal Memory and Structural Plasticity. PLoS One, 10(11), [e0142012]. DOI: 10.1371/journal.pone.0142012 [details / files]
  • Kanatsou, S., Kuil, L. E., Arp, M., Oitzl, M. S., Harris, A. P., Seckl, J. R., ... Joels, M. (2015). Overexpression of mineralocorticoid receptors does not affect memory and anxiety-like behavior in female mice. Frontiers in Behavioral Neuroscience, 9, [182]. DOI: 10.3389/fnbeh.2015.00182 [details] [PDF]
  • Kanatsou, S., ter Horst, J. P., Harris, A. P., Seckl, J. R., Krugers, H. J., & Joëls, M. (2015). Effects of Mineralocorticoid Receptor Overexpression on Anxiety and Memory after Early Life Stress in Female Mice. Frontiers in Behavioral Neuroscience, 9, [374]. DOI: 10.3389/fnbeh.2015.00374 [details] [PDF]
  • Lucassen, P. J., Jacobs, E. H., Hoeijmakers, L., Lesuis, S. L., Krugers, H., Korosi, A., ... Boekhoorn, K. (2015). Stem cells and neurogenesis in relation to Alzheimer's disease Models. In H. G. Kuhn, & A. J. Eisch (Eds.), Neural Stem Cells in Development, Adulthood and Disease. (pp. 53-78). (Stem Cell Biology and Regenerative Medicine series). New Yrok: Human Press. DOI: 10.1007/978-1-4939-1908-6_4 [details]
  • Xiong, H., Cassé, F., Zhou, Y., Zhou, M., Xiong, Z. Q., Joëls, M., ... Krugers, H. J. (2015). mTOR is essential for corticosteroid effects on hippocampal AMPA receptor function and fear memory. Learning & Memory, 22(12), 577-583. DOI: 10.1101/lm.039420.115 [details] [PDF]
  • Xiong, H., & Krugers, H. J. (2015). Tuning hippocampal synapses by stress-hormones: Relevance for emotional memory formation. Brain Research, 1621, 114-120. DOI: 10.1016/j.brainres.2015.04.010 [details]
  • Kanatsou, S., Fearey, B. C., Kuil, L. E., Lucassen, P. J., Harris, A. P., Seckl, J. R., ... Joels, M. (2015). Correction: Overexpression of Mineralocorticoid Receptors Partially Prevents Chronic Stress-Induced Reductions in Hippocampal Memory and Structural Plasticity. PLoS One, 10(12), e0145706. DOI: 10.1371/journal.pone.0145706 [details]
  • Vogel, S., Klumpers, F., Kroes, M. C. W., Oplaat, K. T., Krugers, H. J., Oitzl, M. S., ... Fernández, G. (2015). A Stress-Induced Shift from Trace to Delay Conditioning Depends on the Mineralocorticoid Receptor. Biological Psychiatry, 78(2), 830-739. DOI: 10.1016/j.biopsych.2015.02.014 [details]
  • Vogel, S., Klumpers, F., Krugers, H. J., Fang, Z., Oplaat, K. T., Oitzl, M. S., ... Fernandez, G. (2015). Blocking the Mineralocorticoid Receptor in Humans Prevents the Stress-Induced Enhancement of Centromedial Amygdala Connectivity with the Dorsal Striatum. Neuropsychopharmacology, 40, 947-956. DOI: 10.1038/npp.2014.271 [details]


  • Arp, J. M., ter Horst, J. P., Kanatsou, S., Fernández, G., Joëls, M., Krugers, H. J., & Oitzl, M. S. (2014). Mineralocorticoid receptors guide spatial and stimulus-response learning in mice. PLoS One, 9(1), e86236. DOI: 10.1371/journal.pone.0086236 [details] [PDF]
  • Krugers, H., & Joëls, M. (2014). Long-lasting Consequences of Early Life Stress on Brain Structure, Emotion and Cognition. In C. M. Pariante, & M. D. Lapiz-Bluhm (Eds.), Behavioral neurobiology of stress-related disorders. (pp. 81-92). (Current topics in behavioral neurosciences; No. 18). Heidelberg: Springer. DOI: 10.1007/7854_2014_289 [details]
  • Schouten, M., De Luca, G. M. R., Alatriste González, D. K., de Jong, B. E., Timmermans, W., Xiong, H., ... Fitzsimons, C. P. (2014). Imaging dendritic spines of rat primary hippocampal neurons using structured illumination microscopy. Journal of Visualized Experiments, 87, e51276. DOI: 10.3791/51276 [details]
  • Wang, Q., Verweij, E. W. E., Krugers, H. J., Joels, M., Swaab, D. F., & Lucassen, P. J. (2014). Distribution of the glucocorticoid receptor in the human amygdala; changes in mood disorder patients. Brain Structure and Function, 219(5), 1615-1626. DOI: 10.1007/s00429-013-0589-4 [details]
  • Maccari, S., Krugers, H. J., Morley-Fletcher, S., Szyf, M., & Brunton, P. J. (2014). The consequences of early life adversity: neurobiological, behavioural and epigenetic adaptations. Journal of Neuroendocrinology, 26(10), 707-723. DOI: 10.1111/jne.12175 [details]
  • Sarabdjitsingh, R. A., Zhou, M., Yau, J. L. W., Webster, S. P., Walker, B. R., Seckl, J. R., ... Krugers, H. J. (2014). Inhibiting 11β-hydroxysteroid dehydrogenase type 1 prevents stress effects on hippocampal synaptic plasticity and impairs contextual fear conditioning. Neuropharmacology, 81, 231-236. DOI: 10.1016/j.neuropharm.2014.01.042 [details]
  • Vermetten, E., Zhohar, J., & Krugers, H. J. (2014). Pharmacotherapy in the aftermath of trauma; opportunities in the 'golden hours'. Current psychiatry reports, 16(7), 455. DOI: 10.1007/s11920-014-0455-y [details]


  • Timmermans, W., Xiong, H., Hoogenraad, C. C., & Krugers, H. J. (2013). Stress and excitatory synapses: From health to disease. Neuroscience, 248, 626-636. DOI: 10.1016/j.neuroscience.2013.05.043 [details]
  • Maggio, N., Krugers, H. J., & Segal, M. (2013). Stress and steroid regulation of synaptic transmission: from physiology to pathophysiology. Frontiers in Cellular Neuroscience, 6, 69. DOI: 10.3389/fncel.2012.00069 [details] [PDF]


  • Korosi, A., Naninck, E. F. G., Oomen, C. A., Schouten, M., Krugers, H., Fitzsimons, C., & Lucassen, P. J. (2012). Early-life stress mediated modulation of adult neurogenesis and behavior. Behavioural Brain Research, 227(2), 400-409. DOI: 10.1016/j.bbr.2011.07.037 [details]
  • Krugers, H. J., Karst, H., & Joëls, M. (2012). Interactions between noradrenaline and corticosteroids in the brain: from electrical activity to cognitive performance. Frontiers in Cellular Neuroscience, 6, [15]. DOI: 10.3389/fncel.2012.00015 [details] [PDF]
  • Krugers, H. J., Oomen, C. A., Gumbs, M., Li, M., Velzing, E. H., Joëls, M., & Lucassen, P. J. (2012). Maternal deprivation and dendritic complexity in the basolateral amygdala. Neuropharmacology, 62(1), 534-537. DOI: 10.1016/j.neuropharm.2011.09.022 [details]
  • Ramakers, G. J. A., Wolfer, D., Rosenberger, G., Kuchenbecker, K., Kreienkamp, H. J., Prange-Kiel, J., ... Kutsche, K. (2012). Dysregulation of Rho GTPases in the alphaPix/Arhgef6 mouse model of X-linked intellectual disability is paralleled by impaired structural and synaptic plasticity and cognitive deficits. Human Molecular Genetics, 21(2), 268-286. DOI: 10.1093/hmg/ddr457 [details]
  • Zhou, M., Hoogenraad, C. C., Joëls, M., & Krugers, H. J. (2012). Combined β-adrenergic and corticosteroid receptor activation regulates AMPA receptor function in hippocampal neurons. Journal of Psychopharmacology, 26(4), 516-524. DOI: 10.1177/0269881111424930 [details]
  • van Hasselt, F. N., Boudewijns, Z. S. R. M., van der Knaap, N. J. F., Krugers, H. J., & Joëls, M. (2012). Maternal care received by individual pups correlates with adult CA1 dendritic morphology and synaptic plasticity in a sex-dependent manner. Journal of Neuroendocrinology, 24, 331-340. DOI: 10.1111/j.1365-2826.2011.02233.x [details]
  • van Hasselt, F. N., Tieskens, J. M., Trezza, V., Krugers, H. J., Vanderschuren, L. J. M. J., & Joëls, M. (2012). Within-litter variation in maternal care received by individual pups correlates with adolescent social play behavior in male rats. Physiology & behavior, 106(5), 701-706. DOI: 10.1016/j.physbeh.2011.12.007 [details]
  • van Hasselt, F. N., Visser, L., Tieskens, J. M., Cornelisse, S., Baars, A. M., Lavrijsen, M., ... Joëls, M. (2012). Individual variations in maternal care early in life correlate with later life decision-making and c-fos expression in prefrontal subregions of rats. PLoS One, 7(5), [e37820]. DOI: 10.1371/journal.pone.0037820 [details] [PDF]
  • van Hasselt, F. N., Cornelisse, S., Zhang, T. Y., Meaney, M. J., Velzing, E. H., Krugers, H. J., & Joëls, M. (2012). Adult hippocampal glucocorticoid receptor expression and dentate synaptic plasticity correlate with maternal care received by individuals early in life. Hippocampus, 22(2), 255-266. DOI: 10.1002/hipo.20892 [details]
  • Pillai, A. G., de Jong, D., Kanatsou, S., Krugers, H., Knapman, A., Heinzmann, J-M., ... Touma, C. (2012). Dendritic morphology of hippocampal and amygdalar neurons in adolescent mice is resilient to genetic differences in stress reactivity. PLoS One, e0038971. DOI: 10.1371/journal.pone.0038971 [details] [PDF]


  • Krugers, H. J., Zhou, M., Joëls, M., & Kindt, M. (2011). Regulation of excitatory synapses and fearful memories by stress hormones. Frontiers in Behavioral Neuroscience, 5, [62]. DOI: 10.3389/fnbeh.2011.00062 [details] [PDF]
  • Marlatt, M. W., Philippens, I., Manders, E., Czeh, B., Joëls, M., Krugers, H., & Lucassen, P. J. (2011). Distinct structural plasticity in the hippocampus and amygdala of the middle-aged common marmoset (Callithrix jacchus). Experimental Neurology, 230(2), 291-301. DOI: 10.1016/j.expneurol.2011.05.008 [details]
  • Oomen, C. A., Soeters, H., Audureau, N., Vermunt, L., van Hasselt, F. N., Manders, E. M. M., ... Lucassen, P. J. (2011). Early maternal deprivation affects dentate gyrus structure and emotional learning in adult female rats. Psychopharmacology, 214(1), 249-260. DOI: 10.1007/s00213-010-1922-8 [details] [PDF]
  • Zhou, M., Kindt, M., Joëls, M., & Krugers, H. J. (2011). Blocking mineralocorticoid receptors prior to retrieval reduces contextual fear memory in mice. PLoS One, 6(10), e26220. DOI: 10.1371/journal.pone.0026220 [details] [PDF]


  • Krugers, H. J., Hoogenraad, C. C., & Groc, L. (2010). Stress hormones and AMPA receptor trafficking in synaptic plasticity and memory. Nature Reviews Neuroscience, 11(10), 675-681. DOI: 10.1038/nrn2913 [details]
  • Krugers, H. J., Lucassen, P. J., Karst, H., & Joëls, M. (2010). Chronic stress effects on hippocampal structure and synaptic function: relevance for depression and normalization by anti-glucocorticoid treatment. Frontiers in Synaptic Neuroscience, 2(24), 24. DOI: 10.3389/fnsyn.2010.00024 [details] [PDF]
  • Oomen, C. A., Soeters, H., Audureau, N., Vermunt, L., van Hasselt, F. N., Manders, E. M. M., ... Krugers, H. (2010). Severe early life stress hampers spatial learning and neurogenesis, but improves hippocampal synaptic plasticity and emotional learning under high-stress conditions in adulthood. The Journal of Neuroscience, 30(19), 6635-6645. DOI: 10.1523/JNEUROSCI.0247-10.2010 [details]
  • Zhou, M., Bakker, E. H. M., Velzing, E., Berger, S., Oitzl, M., Joëls, M., & Krugers, H. J. (2010). Both mineralocorticoid and glucocorticoid receptors regulate emotional memory in mice. Neurobiology of Learning and Memory, 94(4), 530-537. DOI: 10.1016/j.nlm.2010.09.005 [details]


  • Alfarez, D. N., De Simoni, A., Velzing, E. H., Bracey, E., Joëls, M., Edwards, F. A., & Krugers, H. J. (2009). Corticosterone reduces dendritic complexity in developing hippocampal CA1 neurons. Hippocampus, 19(9), 828-836. DOI: 10.1002/hipo.20566 [details]
  • Bagot, R. C., van Hasselt, F. N., Champagne, D. L., Meaney, M. J., Krugers, H. J., & Joëls, M. (2009). Maternal care determines rapid effects of stress mediators on synaptic plasticity in adult rat hippocampal dentate gyrus. Neurobiology of Learning and Memory, 92(3), 292-300. DOI: 10.1016/j.nlm.2009.03.004 [details]
  • Joels, M., Karst, H., Krugers, H., & de Kloet, E. R. (2009). Corticosteroid actions on electrical activity in the brain. In A. M. Etgen, & D. W. Pfaff (Eds.), Molecular mechanisms of hormone actions on behavior. (pp. 305-328). Oxford: Academic. [details]
  • Joëls, M., Karst, H., Krugers, H. J., & de Kloet, R. (2009). Corticosteroid Actions on Electrical Activity in the Limbic Brain. In D. W. Pfaff, A. P. Arnold, A. M. Etgen, S. E. Fahrbach, & R. T. Rubin (Eds.), Hormones, brain and behavior. - 2nd ed. - Vol. 3: Cellular and molecular mechanisms of hormone actions on behavior. (pp. 1397-1420). Amsterdam: Elsevier. DOI: 10.1016/B978-008088783-8.00042-5 [details]
  • Joëls, M., Krugers, H. J., Lucassen, P. J., & Karst, H. (2009). Corticosteroid effects on cellular physiology of limbic cells. Brain Research, 1293, 91-100. DOI: 10.1016/j.brainres.2009.03.036 [details]
  • Krugers, H. J., & Hoogenraad, C. C. (2009). Hormonal regulation of AMPA receptor trafficking and memory formation. Frontiers in Synaptic Neuroscience, 1, [2]. DOI: 10.3389/neuro.19.002.2009 [details] [PDF]
  • Oomen, C. A., Girardi, C. E. N., Cahyadi, R., Verbeek, E. C., Krugers, H., Joëls, M., & Lucassen, P. J. (2009). Opposite effects of early maternal deprivation on neurogenesis in male versus female rats. PLoS One, 4(1), e3675. DOI: 10.1371/journal.pone.0003675 [details] [PDF]
  • Pu, Z., Krugers, H. J., & Joëls, M. (2009). Beta-adrenergic facilitation of synaptic plasticity in the rat basolateral amygdala in vitro is gradually reversed by corticosterone. Learning & Memory, 16(2), 155-160. DOI: 10.1101/lm.1272409 [details]
  • Zhou, M., Conboy, L., Sandi, C., Joëls, M., & Krugers, H. J. (2009). Fear conditioning enhances spontaneous AMPA receptor-mediated synaptic transmission in mouse hippocampal CA1 area. European Journal of Neuroscience, 30(8), 1559-1564. DOI: 10.1111/j.1460-9568.2009.06951.x [details]
  • Jaworski, J., Kapitein, L. C., Montenegro Gouveia, S., Dortland, B. R., Wulf, P. S., Grigoriev, I., ... Hoogenraad, C. C. (2009). Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity. Neuron, 61(1), 85-100. DOI: 10.1016/j.neuron.2008.11.013 [details]
  • Martin, S., Henley, J. M., Holman, D., Zhou, M., Wiegert, O., van Spronsen, M., ... Krugers, H. J. (2009). Corticosterone alters AMPAR mobility and facilitates bidirectional synaptic plasticity. PLoS One, 4(3), e4714. DOI: 10.1371/journal.pone.0004714 [details] [PDF]


  • Alfarez, D. N., Karst, H., Velzing, E. H., Joëls, M., & Krugers, H. J. (2008). Opposite effects of glucocorticoid receptor activation on hippocampal CA1 dendritic complexity in chronically stressed and handled animals. Hippocampus, 18(1), 20-28. DOI: 10.1002/hipo.20360 [details]
  • Champagne, D. L., Bagot, R. C., van Hasselt, F., Ramakers, G., Meany, M. J., de Kloet, E. R., ... Krugers, H. (2008). Maternal care and hippocampal plasticity: evidence for experience-dependent structural plasticity, altered synaptic functioning, and differential responsiveness to glucocorticoids and stress. The Journal of Neuroscience, 28(23), 6037-6045. DOI: 10.1523/JNEUROSCI.0526-08.2008 [details]
  • Krugers, H. (2008). Stress en plasticiteit van de hersenen: effecten op functie en structuur. In D. Lafosse Van der Meulen (Ed.), Neuroplasticiteit. Amsterdam: Boom. [details]


  • Joëls, M., Fernandez, G., Krugers, H., & Karst, H. (2015). Brain mineralocorticoid receptor: The other one. Psychoneuroendocrinology, 61, 13. [details]


  • Rouw, R. (speaker) & Krugers, H.J. (speaker) (21-11-2016): Zie je wat je ziet?, Congrescentrum Corpus.
This list of publications is extracted from the UvA-Current Research Information System. Questions? Ask the library or the Pure staff of your faculty / institute. Log in to Pure to edit your publications.
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