Fotograaf: Paul Lucassen

dhr. prof. dr. P.J. (Paul) Lucassen


  • Faculteit der Natuurwetenschappen, Wiskunde en Informatica
    SILS
  • Bezoekadres
    Science Park A
    Science Park 904  Amsterdam
    Kamernummer: C3.270
  • Postadres:
    Science Park  904
    1098 XH  Amsterdam
  • P.J.Lucassen@uva.nl
    T: 0205257631

Newborn neurons (white) in the adult rodent hippocampus (blue), image courtesy Dr B. Czeh.

General information; research topics

Our main interest is structural plasticity in relation to stress and disease. In addition to apoptosis, we focus on the regulation of adult neurogenesis and its relevance for cognition, depression and dementia. Neurogenesis is prominent particularly during early development, and our primary focus is effects of early stress on (development of) the hippocampus. This brain structure is very sensitive to stress hormone action, implicated in learning and memory and affected in both these disease conditions. The hippocampus is furthermore unique as it contains stem cells that continue to generate new neurons in adult animals, including humans, a process called "adult neurogenesis".
Key interest is the functional relevance of adult neurogenesis for brain function. We are interested in whether blockade or normalization of stress effects on neurogenesis in adult life can be beneficial in terms of e.g. recovery from depression. We hypothesize that e.g. stress-inducedreductions in the number of newborn neurons is deterined during early development and will interfere with the role of the hippocampus e.g. in cognition and in negative feedback of the HPA-axis in adult life. We further study how such deficits can be influenced and possibly ameliorated by means of early diet, antidepressant treatment, or physical or cognitively challenging events such as life long learning and exercise.

Personal websites:

http://sils.uva.nl/sfpns

Selected recent publications;

- PJ Lucassen, CP Fitzsimons, A Korosi, M Joels, C Belzung and DN Abrous. Stressing new neurons into depression? Mol Psychiatry 2013 18: 396-397.

- Q Wang, J Van Heerikhuize, L Seress, E Aronica, M Joels, DF Swaab, PJ Lucassen. Glucocorticoid receptor expression in the human hippocampus; stability with age. Neurobiol. Aging, 2013 Jun; 34(6):1662-73.

- C P Fitzsimons, L W A van Hooijdonk, M Schouten, I Zalachoras, V Brinks, T Zheng, T G Schouten, D J Saaltink, T Dijkmans, D A Steindler, J Verhaagen, F J Verbeek, P J Lucassen, E R de Kloet, O C Meijer, H Karst, M Joels, M S Oitzl and E Vreugdenhil. Knockdown of the glucocorticoid receptor alters functional integration of newborn neurons in the adult hippocampus and impairs fear-motivated behavior. Mol Psychiatry 2013 18: 993-1005.

- I Zalachoras, R Houtman, E Atucha, R Devos, AMI Tijssen, P Hu, P Lockey, NA Datson, J Belanoff , PJ Lucassen, M Joëls, ER de Kloet, B Roozendaal, H Hunt, OC Meijer. Differential Targeting of Brain Stress Circuits with a Selective Glucorticoid Receptor Modulator. Proc Natl Acad Sci U S A. 2013 May 7;110(19):7910-5.

- Paul J. Lucassen, Eva F.G. Naninck, Johannes B. van Goudoever, Carlos Fitzsimons, Marian Joels and Aniko Korosi. Perinatal programming of hippocampal structure and function; emerging roles of stress, neurogenesis, epigenetics and early nutrition. Trends in Neuroscience, 2013.

- KJ Doorn, A Goudriaan, C Blits-Huizinga, JGJM Bol, AJ Rozemuller, PVJM Hoogland, PJLucassen,  B Drukarch , WDJ van de Berg and A-M van Dam. Increased amoeboid microglia density is associated with neuronal network disintegration in the olfactory bulb of Parkinson’s and Alzheimer’s disease patients. Brain Pathology 2014.

- Marlatt MW, Potter MC, Bayer TA, van Praag H, Lucassen PJ. Prolonged Running, not Fluoxetine Treatment, Increases Neurogenesis, but does not Alter Neuropathology, in the 3xTg Mouse Model of Alzheimer's Disease. Curr Top Behav Neurosci. 2013;15:313-40.

- Kajo van der Marel, Valentine Bouet, Gideon F. Meerhoff, Pieter Schipper, Anne Klomp, Paul J. Lucassen, Judith R. Homberg, Rick M. Dijkhuizen, Liesbeth Reneman. Long-term oral methylphenidate treatment in adolescent and adult rats: differential effects on brain morphology and function. Neuropsychopharmacology, 2014.

- Q. Wang, E.W.E. Verweij, H.J. Krugers, M Joels, D.F. Swaab, P.J. Lucassen. Distribution of the glucocorticoid receptor in the human amygdala; changes in mood disorder patients. Brain Structure and Function, 2014.

- PJ Lucassen, N Sousa, OFX Almeida, G Rajkowska, J Pruessner, DF Swaab and B Czeh. Neuropathology of Stress. Acta Neuropathologica, 2014.

- CP. Fitzsimons, E van Bodegraven, M Schouten, R Lardenoije, K Kompotis, G Kenis, M van den Hurk, MP. Boks, C Biojone, S Joca, HWM. Steinbusch, K Lunnon, PJ Lucassen, D Mastroeni, J Mill, P Coleman, D van den Hove and BPF. Rutten. Epigenetic regulation of adult neural stem cells. Implications for Alzheimer’s disease. Mol Neurodegeneration, 2014. 

- KJ. Doorn, B Drukarch, AM van Dam, and PJ. Lucassen, Hippocampal Proliferation Is Increased in Presymptomatic Parkinson’s Disease and due to Microglia, Neural Plasticity, 2014. 

- K Boekhoorn, V van Dis, E Goedknegt, A Sobel, PJ. Lucassen and CC. Hoogenraad. The microtubule destabilizing protein stathmin controls the transition from dividing neuronal precursors to post-mitotic neurons during adult hippocampal neurogenesis, Dev Neurobiol, 2014 Jun 7. doi: 10.1002/ 

 

 

Video link to Paul Lucassen on Adult Neurogenesis (YouTube);

 

http://www.youtube.com/watch?v=kIzrLD70vEA

 

Publications 2014;

-Bielefeld P, van Vliet EA, Gorter JA, Lucassen PJ, Fitzsimons CP. Different subsets of newborn granule cells: a possible role in epileptogenesis? Eur J Neurosci. 2014 Jan;39(1):1-11. doi: 10.1111/ejn.12387.

-Karlijn J. Doorn, Andrea Goudriaan, Carla Blits-Huizinga, John G.J.M. Bol, Annemieke J. Rozemuller, Piet V.J.M. Hoogland, Paul J. Lucassen,  Benjamin Drukarch , Wilma D.J. van de Berg and Anne-Marie van Dam. Increased Amoeboid Microglial Density in the Olfactory Bulb of Parkinson's and Alzheimer's Patients. Brain Pathology, Volume 24, Issue 2 pp 152-165, 2014.

-A. Klomp, L. Václavů, G. Meerhoff, L. Reneman, P.J. Lucassen. Effects of chronic fluoxetine treatment on neurogenesis and tryptophan hydroxylase expression in adolescent and adult rats. PlosOne, May 14;9(5):e97603. doi: 10.1371/journal.pone.0097603, 2014. 

-Kajo van der Marel, Anne Klomp, Gideon F Meerhoff, Pieter Schipper, Paul J Lucassen, Judith R Homberg, Rick M Dijkhuizen and Liesbeth Reneman. Long-Term Oral Methylphenidate Treatment in Adolescent and Adult Rats: Differential Effects on Brain Morphology and Function. Neuropsychopharmacology 2014, 39 (2): 263-273.

-Q. Wang, E.W.E. Verweij, H.J. Krugers, M Joels, D.F. Swaab, P.J. Lucassen. Distribution of the glucocorticoid receptor in the human amygdala; changes in mood disorder patients. Brain Structure and Function, in press, 2014.

- Paul J. Lucassen, Jens Pruessner, Nuno Sousa, Osborne F.X. Almeida, Anne Marie Van Dam, Grazyna Rajkowska, Dick F. Swaab and Boldizsár Czéh. Neuropathology of Stress. Acta Neuropathol. 2014 Jan;127(1):109-35.

- Hoeijmakers L, Harbich D, Schmid B, Lucassen PJ, Wagner KV, Schmidt MV, Hartmann J. Depletion of FKBP51 in Female Mice Shapes HPA Axis Activity. PloS One. 2014 Apr 23;9(4):e95796.

- Manila Loi, Sylwia Koricka, Paul J. Lucassen, Marian Joels. Age- and sex-dependent effects of early life stress on hippocampal neurogenesis. Frontiers, Special issue on perinatal stress and psychopathology (Eds; N Daskalakis and R Yehuda), Front Endocrinol (Lausanne). 2014 Feb 20;5:13.

- Karlijn J. Doorn, Benjamin Drukarch, Anne-Marie van Dam, and Paul J. Lucassen, Hippocampal Proliferation Is Increased in Presymptomatic Parkinson’s Disease and due to Microglia, Neural Plasticity, vol. 2014, Article ID 959154, 13 pages, 2014. doi:10.1155/2014/959154

- Karin Boekhoorn, Vera van Dis, Erika Goedknegt, André Sobel, Paul J. Lucassen and Casper C. Hoogenraad. The microtubule destabilizing protein stathmin controls the transition from dividing neuronal precursors to post-mitotic neurons during adult hippocampal neurogenesis, Dev Neurobiol, 2014 Jun 7. doi: 10.1002/dneu.22200.

- Michael W. Marlatt, Jan Bauer, Eleonora Aronica, Elise S. van Haastert, Jeroen J.M. Hoozemans, Marian Joels and Paul J Lucassen. Proliferation in the Alzheimer hippocampus is due to microglia, not astroglia, and occurs at sites of amyloid deposition. Neural Plasticity, 2014.

-CP Fitzsimons, Emma van Bodegraven, Marijn Schouten, Roy Lardenoije, Konstantinos Kompotis, Gunter Kenis, Mark van den Hurk, Marco P. Boks, Caroline Biojone, Samia Joca, Harry W.M. Steinbusch, Katie Lunnon, PJ Lucassen, Diego Mastroeni, Jonathan Mill, Paul Coleman, Daniel van den Hove and Bart P.F. Rutten. Epigenetic regulation of adult neural stem cells. Implications for Alzheimer’s disease. Mol Neurodegen, 2014.

- Karlijn J. Doorn, Tim Moors, Benjamin Drukarch, Paul J. Lucassen and Anne-Marie van Dam. Different microglial phenotypes in the substantia nigra and hippocampus of incidental cases and Parkinson patients: a role for TLR-2 in disease progression ? Acta Neuropathologica Communications.2014, 2:90  DOI: 10.1186.

 

 

2016

  • Bielefeld, P., Schouten, M., Lucassen, P. J., & Fitzsimons, C. P. (2016). Transcription factor oscillations in neural stem cells; relevance for stem cell control. Frontiers in Neurogenesis[details]
  • Fitzsimons, C. P., Herbert, J., Schouten, M., Meijer, O. C., Lucassen, P. J., & Lightman, S. (2016). Circadian and ultradian glucocorticoid rhythmicity: Implications for the effects of glucocorticoids on neural stem cells and adult hippocampal neurogenesis. Frontiers in Neuroendocrinology, 41, 44-58. DOI: 10.1210/en.2012-1484 [details]
  • Hoeijmakers, L., Heinen, Y., van Dam, A-M., Lucassen, P. J., & Korosi, A. (2016). Microglial priming and Alzheimer’s disease: a possible role for (early) immune challenges and epigenetics? Frontiers in Human Neuroscience, 10, [398]. DOI: 10.3389/fnhum.2016.00398 [details] [PDF]
  • Hu, P., Wang, Y., Liu, J., Meng, F. T., Qi, X. R., Chen, L., ... Zhou, J. N. (2016). Chronic retinoic acid treatment suppresses adult hippocampal neurogenesis, in close correlation with depressive-like behavior. Hippocampus, 26(7), 911-923. DOI: 10.1002/hipo.22574 [details]
  • Lesuis, S. L., Maurin, H., Borghgraef, P., Lucassen, P. J., Van Leuven, F., & Krugers, H. J. (2016). Positive and negative early life experiences differentially modulate long term survival and amyloid protein levels in a mouse model of Alzheimer’s disease. OncoTarget, 7(26), 39118-39135. DOI: 10.18632/oncotarget.9776 [details] [PDF]
  • Lucassen, P. J., & Oomen, C. A. (2016). Stress, hippocampal neurogenesis and cognition: functional correlations. Frontiers in Biology, 11(3), 182-192. DOI: 10.1007/s11515-016-1412-4 [details]
  • Lucassen, P. J., Korosi, A., Krugers, H., & Oomen, C. A. (2016). Early life stress and sex-dependent effects on hippocampal neurogenesis. In G. Fink (Ed.), Handbook of Stress. Amsterdam: Elsvier Publishers. [details]
  • Lucassen, P. J., Oomen, C. A., Schouten, M., Encinas, J. M., & Fitzsimons, C. P. (2016). Adult Neurogenesis, Chronic Stress and Depression. In J. J. Canales (Ed.), Adult neurogenesis in the hippocampus: health, psychopathology, and brain disease. (pp. 177-206). London: Academic Press. DOI: 10.1016/B978-0-12-801977-1.00008-8 [details]
  • Naninck, E. F. G., Oosterink, J. E., Yam, K. Y., de Vries, L. P., Schierbeek, H., van Goudoever, J. B., ... Korosi, A. (2016). Early micronutrient supplementation protects against early stress induced cognitive impairments. The FASEB Journal. DOI: 10.1096/fj.201600834R [details]
  • Reemst, K., Noctor, S. C., Lucassen, P. J., & Hol, E. M. (2016). The indispensable roles of microglia and astrocytes during brain development. Frontiers in Human Neuroscience, 10, [566]. DOI: 10.3389/fnhum.2016.00566 [details] [PDF]
  • Schouten, M., Bielefeld, P., Fratantoni, S. A., Hubens, C. H., Piersma, S. R., Pham, T. V., ... Fitzsimons, C. P. (2016). Multi-omics profile of the mouse dentate gyrus after kainic acid induced status epilepticus. Scientific Data, 3, [160068]. DOI: 10.1038/sdata.2016.68 [details] [PDF]
  • Schrantee, A. G. M., Tremoleda, J. L., Wylezinska-Arridge, M., Bouet, V., Hesseling, P., Meerhoff, G. F., ... Reneman, L. (2016). Repeated dexamphetamine treatment alters the dopaminergic system and increases the phMRI response to methylphenidate. PLoS One[details]
  • Herbert, J., & Lucassen, P. J. (2016). Depression as a risk factor for Alzheimer's disease: Genes, steroids, cytokines and neurogenesis - what do we need to know? Frontiers in Neuroendocrinology, 41, 153-171. DOI: 10.1016/j.yfrne.2015.12.001 [details]
  • Kandola, A., Hendrikse, J., Lucassen, P. J., & Yücel, M. (2016). Aerobic exercise as a tool to improve hippocampal plasticity and function in humans: practical implications for mental health treatment. Frontiers in Human Neuroscience, 10, [373]. DOI: 10.3389/fnhum.2016.00373 [details] [PDF]
  • Schrantee, A., Tamminga, H. G. H., Bouziane, C., Bottelier, M. A., Bron, E. E., Mutsaerts, H. J. M. M., ... Reneman, L. (2016). Age-Dependent Effects of Methylphenidate on the Human Dopaminergic System in Young vs Adult Patients With Attention-Deficit/Hyperactivity Disorder: A Randomized Clincal Trial. JAMA Psychiatry, 73(9), 955-962. DOI: 10.1001/jamapsychiatry.2016.1572 [details]
  • Zhao, J., Verwer, R. W. H., van Wamelen, D. J., Qi, X. R., Gao, S. F., Lucassen, P. J., & Swaab, D. F. (2016). Prefrontal changes in the glutamate-glutamine cycle and neuronal/glial glutamate transporters in depression with and without suicide. Journal of Psychiatric Research, 82, 8-15. DOI: 10.1016/j.jpsychires.2016.06.017 [details]

2015

  • Doorn, K. J., Brevé, J. J. P., Drukarch, B., Boddeke, H. W., Huitinga, I., Lucassen, P. J., & van Dam, A. M. (2015). Brain region-specific gene expression profiles in freshly isolated rat microglia. Frontiers in Cellular Neuroscience, 9, 84. DOI: 10.3389/fncel.2015.00084 [details] [PDF]
  • Kanatsou, S., Fearey, B. C., Kuil, L. E., Lucassen, P. J., Harris, A. P., Seckl, J. R., ... Joels, M. (2015). Overexpression of Mineralocorticoid Receptors Partially Prevents Chronic Stress-Induced Reductions in Hippocampal Memory and Structural Plasticity. PLoS One, 10(11), [e0142012]. DOI: 10.1371/journal.pone.0142012 [details / files]
  • Loi, M., Mossink, J. C. L., Meerhoff, G. F., den Blaauwen, J. L., Lucassen, P. J., & Joëls, M. (2015). Effects of early-life stress on cognitive function and hippocampal structure in female rodents. Neuroscience. DOI: 10.1016/j.neuroscience.2015.08.024 [details]
  • Lucassen, P. J., Jacobs, E. H., Hoeijmakers, L., Lesuis, S. L., Krugers, H., Korosi, A., ... Boekhoorn, K. (2015). Stem cells and neurogenesis in relation to Alzheimer's disease Models. In H. G. Kuhn, & A. J. Eisch (Eds.), Neural Stem Cells in Development, Adulthood and Disease. (pp. 53-78). (Stem Cell Biology and Regenerative Medicine series). New Yrok: Human Press. DOI: 10.1007/978-1-4939-1908-6_4 [details]
  • Lucassen, P. J., Oomen, C. A., Naninck, E. F. G., Fitzsimons, C. P., van Dam, A. M., Czeh, B., & Korosi, A. (2015). Regulation of Adult Neurogenesis and Plasticity by (Early) Stress, Glucocorticoids, and Inflammation. Cold Spring Harbor Perspectives in Biology, 7(9), [a021303]. DOI: 10.1101/cshperspect.a021303 [details]
  • Naninck, E. F. G., Hoeijmakers, L., Kakava-Georgiadou, N., Meesters, A., Lazic, S. E., Lucassen, P. J., & Korosi, A. (2015). Chronic early life stress alters developmental and adult neurogenesis and impairs cognitive function in mice. Hippocampus, 25(3), 309-325. DOI: 10.1002/hipo.22374 [details]
  • Naninck, E. F. G., Lucassen, P. J., & Korosi, A. (2015). Consequences of early-life experiences on cognition and emotion: a role for nutrition and epigenetic mechanisms. In T. Canli (Ed.), The Oxford handbook of molecular psychology. (pp. 311-336). Oxford: Oxford University Press. DOI: 10.1093/oxfordhb/9780199753888.013.003 [details]
  • Schouten, M., Fratantoni, S. A., Hubens, C. J., Piersma, S. R., Pham, T. V., Bielefeld, P., ... Fitzsimons, C. P. (2015). MicroRNA-124 and -137 cooperativity controls caspase-3 activity through BCL2L13 in hippocampal neural stem cells. Scientific Reports, 5, [12448]. DOI: 10.1038/srep12448 [details / files]
  • Yam, K. Y., Naninck, E. F. G., Schmidt, M. V., Lucassen, P. J., & Korosi, A. (2015). Early-life adversity programs emotional functions and the neuroendocrine stress system: the contribution of nutrition, metabolic hormones and epigenetic mechanisms. Stress - the International Journal on the Biology of Stress, 18(3), 328-342. DOI: 10.3109/10253890.2015.1064890 [details]
  • Oosterink, J. E., Naninck, E. F. G., Korosi, A., Lucassen, P. J., van Goudoever, J. B., & Schierbeek, H. (2015). Accurate measurement of the essential micronutrients methionine, homocysteine, vitamins B6, B12, B9 and their metabolites in plasma, brain and maternal milk of mice using LC/MS ion trap analysis. Journal of Chromatography B, 998-999, 106-113. DOI: 10.1016/j.jchromb.2015.07.008 [details]
  • Schrantee, A., Václavů, L., Heijtel, D. F. R., Caan, M. W. A., Gsell, W., Lucassen, P. J., ... Reneman, L. (2015). Dopaminergic System Dysfunction in Recreational Dexamphetamine Users. Neuropsychopharmacology, 40, 1172-1180. DOI: 10.1038/npp.2014.301 [details]
  • van der Marel, K., Bouet, V., Meerhoff, G. F., Freret, T., Boulouard, M., Dauphin, F., ... Reneman, L. (2015). Effects of long-term methylphenidate treatment in adolescent and adult rats on hippocampal shape, functional connectivity and adult neurogenesis. Neuroscience, 309, 243-258. DOI: 10.1016/j.neuroscience.2015.04.044 [details]

2014

  • Bielefeld, P., van Vliet, E. A., Gorter, J. A., Lucassen, P. J., & Fitzsimons, C. P. (2014). Different subsets of newborn granule cells: a possible role in epileptogenesis? European Journal of Neuroscience, 39(1), 1-11. DOI: 10.1111/ejn.12387 [details]
  • Boekhoorn, K., van Dis, V., Goedknegt, E., Sobel, A., Lucassen, P. J., & Hoogenraad, C. C. (2014). The microtubule destabilizing protein stathmin controls the transition from dividing neuronal precursors to postmitotic neurons during adult hippocampal neurogenesis. Developmental Neurobiology, 74(12), 1226-1242. DOI: 10.1002/dneu.22200 [details]
  • Doorn, K. J., Drukarch, B., van Dam, A-M., & Lucassen, P. J. (2014). Hippocampal Proliferation Is Increased in Presymptomatic Parkinson’s Disease and due to Microglia. Neural Plasticity, 2014, 959154. DOI: 10.1155/2014/959154 [details] [PDF]
  • Doorn, K. J., Goudriaan, A., Blits-Huizinga, C., Bol, J. G., Rozemuller, A. J., Hoogland, P. V., ... van Dam, A. M. (2014). Increased Amoeboid Microglial Density in the Olfactory Bulb of Parkinson's and Alzheimer's Patients. Brain Pathology, 24(2), 152-165. DOI: 10.1111/bpa.12088 [details]
  • Doorn, K. J., Moors, T., Drukarch, B., van de Berg, W. D. J., Lucassen, P. J., & van Dam, A-M. (2014). Microglial phenotypes and toll-like receptor 2 in the substantia nigra and hippocampus of incidental Lewy body disease cases and Parkinson's disease patients. Acta Neuropathologica Communications, 2, 90. DOI: 10.1186/s40478-014-0090-1 [details] [PDF]
  • Fitzsimons, C. P., van Bodegraven, E., Schouten, M., Lardenoije, R., Kompotis, K., Kenis, G., ... Rutten, B. P. F. (2014). Epigenetic regulation of adult neural stem cells: implications for Alzheimer's disease. Molecular Neurodegeneration, 9, 25. DOI: 10.1186/1750-1326-9-25 [details] [PDF]
  • Hoeijmakers, L., Harbich, D., Schmid, B., Lucassen, P. J., Wagner, K. V., Schmidt, M. V., & Hartmann, J. (2014). Depletion of FKBP51 in female mice shapes HPA axis activity. PLoS One, 9(4), e95796. DOI: 10.1371/journal.pone.0095796 [details] [PDF]
  • Hoeijmakers, L., Lucassen, P. J., & Korosi, A. (2014). The interplay of early-life stress, nutrition, and immune activation programs adult hippocampal structure and function. Frontiers in Molecular Neuroscience, 7, 103. DOI: 10.3389/fnmol.2014.00103 [details] [PDF]
  • Klomp, A., Václavů, L., Meerhoff, G. F., Reneman, L., & Lucassen, P. J. (2014). Effects of chronic fluoxetine treatment on neurogenesis and tryptophan hydroxylase expression in adolescent and adult rats. PLoS One, 9(5), e97603. DOI: 10.1371/journal.pone.0097603 [details / files]
  • Loi, M., Koricka, S., Lucassen, P. J., & Joëls, M. (2014). Age- and sex-dependent effects of early life stress on hippocampal neurogenesis. Frontiers in Endocrinology, 5, 13. DOI: 10.3389/fendo.2014.00013 [details] [PDF]
  • Lucassen, P. J., Pruessner, J., Sousa, N., Almeida, O. F. X., van Dam, A. M., Rajkowska, G., ... Czéh, B. (2014). Neuropathology of stress. Acta Neuropathologica, 127(1), 109-135. DOI: 10.1007/s00401-013-1223-5 [details] [PDF]
  • Marlatt, M. W., Bauer, J., Aronica, E., van Haastert, E. S., Hoozemans, J. J. M., Joels, M., & Lucassen, P. J. (2014). Proliferation in the Alzheimer hippocampus is due to microglia, not astroglia, and occurs at sites of amyloid deposition. Neural Plasticity, 2014, 693851. DOI: 10.1155/2014/693851 [details] [PDF]
  • Wang, Q., Verweij, E. W. E., Krugers, H. J., Joels, M., Swaab, D. F., & Lucassen, P. J. (2014). Distribution of the glucocorticoid receptor in the human amygdala; changes in mood disorder patients. Brain Structure and Function, 219(5), 1615-1626. DOI: 10.1007/s00429-013-0589-4 [details]
  • van der Marel, K., Klomp, A., Meerhoff, G. F., Schipper, P., Lucassen, P. J., Homberg, J. R., ... Reneman, L. (2014). Long-Term Oral Methylphenidate Treatment in Adolescent and Adult Rats: Differential Effects on Brain Morphology and Function. Neuropsychopharmacology, 39, 263-273. DOI: 10.1038/npp.2013.169 [details]

2013

  • Fitzsimons, C. P., van Hooijdonk, L. W. A., Schouten, M., Zalachoras, I., Brinks, V., Zheng, T., ... Vreugdenhil, E. (2013). Knockdown of the glucocorticoid receptor alters functional integration of newborn neurons in the adult hippocampus and impairs fear-motivated behavior. Molecular Psychiatry, 18(9), 993-1005. DOI: 10.1038/mp.2012.123 [details]
  • Hu, P., Liu, J., Zhao, Q., Qi, X. R., Qi, C. C., Lucassen, P. J., & Zhou, J. N. (2013). All-trans retinoic acid-induced hypothalamus-pituitary-adrenal hyperactivity involves glucocorticoid receptor dysregulation. Translational Psychiatry, 3, e336. DOI: 10.1038/tp.2013.98 [details / files]
  • Lucassen, P. J., Fitzsimons, C. P., Korosi, A., Joels, M., Belzung, C., & Abrous, D. N. (2013). Stressing new neurons into depression? Molecular Psychiatry, 18(4), 396-397. DOI: 10.1038/mp.2012.39 [details / files]
  • Lucassen, P. J., Naninck, E. F. G., van Goudoever, J. B., Fitzsimons, C., Joels, M., & Korosi, A. (2013). Perinatal programming of adult hippocampal structure and function; emerging roles of stress, nutrition and epigenetics. Trends in Neurosciences, 36(11), 621-631. DOI: 10.1016/j.tins.2013.08.002 [details]
  • Marlatt, M. W., Potter, M. C., Bayer, T. A., van Praag, H., & Lucassen, P. J. (2013). Prolonged Running, not Fluoxetine Treatment, Increases Neurogenesis, but does not Alter Neuropathology, in the 3xTg Mouse Model of Alzheimer's Disease. Current Topics in Behavioral Neurosciences, 15, 313-340. DOI: 10.1007/7854_2012_237 [details]
  • Wang, Q., van Heerikhuize, J., Aronica, E., Kawata, M., Seress, L., Joels, M., ... Lucassen, P. J. (2013). Glucocorticoid receptor protein expression in human hippocampus; stability with age. Neurobiology of Aging, 34(6), 1662-1673. DOI: 10.1016/j.neurobiolaging.2012.11.019 [details]
  • Qi, X. R., Kamphuis, W., Wang, S., Wang, Q., Lucassen, P. J., Zhou, J. N., & Swaab, D. F. (2013). Aberrant stress hormone receptor balance in the human prefrontal cortex and hypothalamic paraventricular nucleus of depressed patients. Psychoneuroendocrinology, 38(6), 863-870. DOI: 10.1016/j.psyneuen.2012.09.014 [details]
  • Zalachoras, I., Houtman, R., Atucha, E., Devos, R., Tijssen, A. M. I., Hu, P., ... Meijer, O. C. (2013). Differential targeting of brain stress circuits with a selective glucocorticoid receptor modulator. Proceedings of the National Academy of Sciences of the United States of America, 110(19), 7910-7915. DOI: 10.1073/pnas.1219411110 [details]

2012

  • Doorn, K. J., Lucassen, P. J., Boddeke, H. W., Prins, M., Berendse, H. W., Drukarch, B., & van Dam, A. M. (2012). Emerging roles of microglial activation and non-motor symptoms in Parkinson's disease. Progress in Neurobiology, 98(2), 222-238. DOI: 10.1016/j.pneurobio.2012.06.005 [details]
  • Fitzsimons, C. P., Vreugdenhil, E., & Lucassen, P. J. (2012). Inhibition of Adult Neurogenesis through ERK5 knockdown Impairs Complex Hippocampus-dependent Spatial Memory Tasks. Future Neurology, 7(5), 531-535. DOI: 10.2217/fnl.12.55 [details]
  • Hu, P., Oomen, C., van Dam, A. M., Wester, J., Zhou, J. N., Joëls, M., & Lucassen, P. J. (2012). A single-day treatment with mifepristone is sufficient to normalize chronic glucocorticoid induced suppression of hippocampal cell proliferation. PLoS One, 7(9), [e46224]. DOI: 10.1371/journal.pone.0046224 [details] [PDF]
  • Korosi, A., Naninck, E. F. G., Oomen, C. A., Schouten, M., Krugers, H., Fitzsimons, C., & Lucassen, P. J. (2012). Early-life stress mediated modulation of adult neurogenesis and behavior. Behavioural Brain Research, 227(2), 400-409. DOI: 10.1016/j.bbr.2011.07.037 [details]
  • Krugers, H. J., Oomen, C. A., Gumbs, M., Li, M., Velzing, E. H., Joëls, M., & Lucassen, P. J. (2012). Maternal deprivation and dendritic complexity in the basolateral amygdala. Neuropharmacology, 62(1), 534-537. DOI: 10.1016/j.neuropharm.2011.09.022 [details]
  • Lucassen, P. J. (2012). Chemotherapy modulates specific aspects of cognition parallel to neurogenesis (Commentary on Nokia et al.). European Journal of Neuroscience, 36, 3519-3520. DOI: 10.1111/ejn.12056 [details / files]
  • Marlatt, M. W., Potter, M. C., Lucassen, P. J., & van Praag, H. (2012). Running throughout middle-age improves memory function, hippocampal neurogenesis and BDNF levels in female C57Bl/6J mice. Developmental Neurobiology, 72(6), 943-952. DOI: 10.1002/dneu.22009 [details]
  • Schouten, M., Buijink, M. R., Lucassen, P. J., & Fitzsimons, C. P. (2012). New neurons in aging brains: molecular control by small non-coding RNAs. Frontiers in Neuroscience, 6, 25. DOI: 10.3389/2Ffnins.2012.00025 [details / files]
  • Wang, Q., Joëls, M., Swaab, D. F., & Lucassen, P. J. (2012). Hippocampal GR expression is increased in elderly depressed females. Neuropharmacology, 62(1), 527-533. DOI: 10.1016/j.neuropharm.2011.09.014 [details]
  • Claessens, S. E. F., Belanoff, J. K., Kanatsou, S., Lucassen, P. J., Champagne, D. L., & de Kloet, E. R. (2012). Acute effects of neonatal dexamethasone treatment on proliferation and astrocyte immunoreactivity in hippocampus and corpus callosum: Towards a rescue strategy. Brain Research, 1482, 1-12. DOI: 10.1016/j.brainres.2012.08.017 [details]
  • Datson, N. A., Speksnijder, N., Mayer, J. L., Steenbergen, P. J., Korobko, O., Goeman, J., ... Lucassen, P. J. (2012). The transcriptional response to chronic stress and glucocorticoid receptor blockade in the hippocampal dentate gyrus. Hippocampus, 22(2), 359-371. DOI: 10.1002/hipo.20905 [details]
  • Saaltink, D. J., Håvik, B., Verissimo, C., Lucassen, P. J., & Vreugdenhil, E. (2012). Doublecortin and doublecortin-like are expressed in overlapping and non-overlapping neuronal cell population: implications for neurogenesis. The journal of comparative neurology, 520(13), 2805-2823. DOI: 10.1002/cne.23144 [details]

2011

  • Eendebak, R. J. A. H., Lucassen, P. J., & Fitzsimons, C. P. (2011). Nuclear receptors and microRNAs: who regulates the regulators in neural stem cells? FEBS Letters, 585(5), 717-22. DOI: 10.1016/j.febslet.2011.01.039 [details]
  • Lucassen, P. J., Fitzsimons, C. P., Vreugdenhil, E., Hu, P., Oomen, C., Revsin, Y., ... de Kloet, E. R. (2011). Regulation of structural plasticity and neurogenesis during stress and diabetes; protective effects of glucocorticoid receptor antagonists. In A. G. Gravanis, & S. H. Mellon (Eds.), Hormones in neurodegeneration, neuroprotection, and neurogenesis. (pp. 103-120-6). Wiley-VCH. [details]
  • Lucassen, P. J., Fitzsimons, C. P., Vreugdenhil, E., Hu, P., Oomen, C., Revsin, Y., ... de Kloet, E. R. (2011). Regulation of structural plasticity and neurogenesis during stress and diabetes; protective effects of glucocorticoid receptor antagonists. In A. G. Gravanis, & S. H. Mellon (Eds.), Hormones in neurodegeneration, neuroprotection, and neurogenesis. (pp. 103-120). Weinheim, Germany: Wiley-VCH. DOI: 10.1002/9783527633968.ch6 [details] [PDF]
  • Marlatt, M. W., Philippens, I., Manders, E., Czeh, B., Joëls, M., Krugers, H., & Lucassen, P. J. (2011). Distinct structural plasticity in the hippocampus and amygdala of the middle-aged common marmoset (Callithrix jacchus). Experimental Neurology, 230(2), 291-301. DOI: 10.1016/j.expneurol.2011.05.008 [details]
  • Naninck, E. F. G., Lucassen, P. J., & Bakker, J. (2011). Sex differences in adolescent depression: do sex hormones determine vulnerability? Journal of Neuroendocrinology, 23(5), 383-392. DOI: 10.1111/j.1365-2826.2011.02125.x [details]
  • Oomen, C. A., Soeters, H., Audureau, N., Vermunt, L., van Hasselt, F. N., Manders, E. M. M., ... Lucassen, P. J. (2011). Early maternal deprivation affects dentate gyrus structure and emotional learning in adult female rats. Psychopharmacology, 214(1), 249-260. DOI: 10.1007/s00213-010-1922-8 [details] [PDF]
  • Bruel-Jungerman, E., Lucassen, P. J., & Francis, F. (2011). Cholinergic influences on cortical development and adult neurogenesis. Behavioural Brain Research, 221(2), 379-388. DOI: 10.1016/j.bbr.2011.01.021 [details]
  • Lemmens, M. A. M., Sierksma, A. S. R., Rutten, B. P. F., Dennissen, F., Steinbusch, H. W. M., Lucassen, P. J., & Schmitz, C. (2011). Age-related changes of neuron numbers in the frontal cortex of a transgenic mouse model of Alzheimer's disease. Brain Structure and Function, 216(3), 227-237. DOI: 10.1007/s00429-011-0305-1 [details] [PDF]
  • Novati, A., Hulshof, H. J., Koolhaas, J. M., Lucassen, P. J., & Meerlo, P. (2011). Chronic sleep restriction causes a decrease in hippocampal volume in adolescent rats, which is not explained by changes in glucocorticoid levels or neurogenesis. Neuroscience, 190, 145-155. DOI: 10.1016/j.neuroscience.2011.06.027 [details]
  • Van Bokhoven, P., Oomen, C. A., Hoogendijk, W. J., Smit, A. B., Lucassen, P. J., & Spijker, S. (2011). Reduction in hippocampal neurogenesis after social defeat is long-lasting and responsive to late antidepressant treatment. European Journal of Neuroscience, 33(10), 1833-1840. DOI: 10.1111/j.1460-9568.2011.07668.x [details]
  • Xiao, A. W., He, J., Wang, Q., Luo, Y., Sun, Y., Zhou, Y. P., ... Dai, J. P. (2011). The origin and development of plaques and phosphorylated tau are associated with axonopathy in Alzheimer's disease. Neuroscience bulletin, 27(5), 287-99. DOI: 10.1007/s12264-011-1736-7 [details]
  • van Tijn, P., Kamphuis, W., Marlatt, M. W., Hol, E. M., & Lucassen, P. J. (2011). Presenilin mouse and zebrafish models for dementia: Focus on neurogenesis. Progress in Neurobiology, 93(2), 149-164. DOI: 10.1016/j.pneurobio.2010.10.008 [details]

2010

  • Krugers, H. J., Lucassen, P. J., Karst, H., & Joëls, M. (2010). Chronic stress effects on hippocampal structure and synaptic function: relevance for depression and normalization by anti-glucocorticoid treatment. Frontiers in Synaptic Neuroscience, 2(24), 24. DOI: 10.3389/fnsyn.2010.00024 [details] [PDF]
  • Lucassen, P. J., Meerlo, P., Naylor, A. S., van Dam, A. M., Dayer, A. G., Fuchs, E., ... Czéh, B. (2010). Regulation of adult neurogenesis by stress, sleep disruption, exercise and inflammation: Implications for depression and antidepressant action. European Neuropsychopharmacology, 20(1), 1-17. DOI: 10.1016/j.euroneuro.2009.08.003 [details]
  • Lucassen, P. J., Stumpel, M. W., Wang, Q., & Aronica, E. (2010). Decreased numbers of progenitor cells but no response to antidepressant drugs in the hippocampus of elderly depressed patients. Neuropharmacology, 58(6), 940-949. DOI: 10.1016/j.neuropharm.2010.01.012 [details]
  • Marlatt, M. W., & Lucassen, P. J. (2010). Neurogenesis and Alzheimer's disease: biology and pathophysiology in mice and men. Current Alzheimer Research, 7(2), 113-125. DOI: 10.2174/156720510790691362 [details]
  • Marlatt, M. W., Lucassen, P. J., & van Praag, H. (2010). Comparison of neurogenic effects of fluoxetine, duloxetine and running in mice. Brain Research, 1341, 93-99. DOI: 10.1016/j.brainres.2010.03.086 [details]
  • Oomen, C. A., Soeters, H., Audureau, N., Vermunt, L., van Hasselt, F. N., Manders, E. M. M., ... Krugers, H. (2010). Severe early life stress hampers spatial learning and neurogenesis, but improves hippocampal synaptic plasticity and emotional learning under high-stress conditions in adulthood. The Journal of Neuroscience, 30(19), 6635-6645. DOI: 10.1523/JNEUROSCI.0247-10.2010 [details]
  • Christensen, D. Z., Schneider-Axmann, T., Lucassen, P. J., Bayer, T. A., & Wirths, O. (2010). Accumulation of intraneuronal Aβ correlates with ApoE4 genotype. Acta Neuropathologica, 119(5), 555-566. DOI: 10.1007/s00401-010-0666-1 [details] [PDF]
  • Wirths, O., Bethge, T., Marcello, A., Harmeier, A., Jawhar, S., Lucassen, P. J., ... Bayer, T. A. (2010). Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer’s disease cases. Journal of Neural Transmission, 117(1), 85-96. DOI: 10.1007/s00702-009-0314-x [details] [PDF]

2009

  • Boekhoorn, K., & Lucassen, P. J. (2009). Nieuwe neuronen in volwassen hersenen. Tijdschrift voor Neuropsychiatrie & Gedragsneurologie, (juni), 119-123. [details]
  • Boer, K., Lucassen, P. J., Spliet, W. G. M., Vreugdenhil, E., van Rijen, P. C., Troost, D., ... Aronica, E. (2009). Doublecortin-like (DCL) expression in focal cortical dysplasia and cortical tubers. Epilepsia, 50(12), 2629-2637. DOI: 10.1111/j.1528-1167.2009.02191.x [details]
  • Joëls, M., Krugers, H. J., Lucassen, P. J., & Karst, H. (2009). Corticosteroid effects on cellular physiology of limbic cells. Brain Research, 1293, 91-100. DOI: 10.1016/j.brainres.2009.03.036 [details]
  • Lucassen, P. J., & Swaab, D. F. (2009). Endocrine disorders of development and growth. In M. D. Binder, N. Hirokawa, & U. Windhorst (Eds.), Encyclopedia of neuroscience. (pp. 1103-1106). Berlin: Springer. [details]
  • Lucassen, P. J., & Swaab, D. F. (2009). Hypothalamo-pituitary-adrenal axis, stress and depression. In M. D. Binder, N. Hirokawa, & U. Windhorst (Eds.), Encyclopedia of neuroscience. (pp. 1892-1895). Berlin: Springer. [details]
  • Lucassen, P. J., Bosch, O. J., Jousma, E., Krömer, S. A., Andrew, R., Seckl, J. R., & Neumann, I. D. (2009). Prenatal stress reduces postnatal neurogenesis in rats selectively bred for high, but not low, anxiety: Possible key role of placental 11β-hydroxysteroid dehydrogenase type 2. European Journal of Neuroscience, 29(1), 97-103. DOI: 10.1111/j.1460-9568.2008.06543.x [details]
  • Lucassen, P. J., Meerlo, P., Naylor, A. S., van Dam, A. M., Dayer, A. G., Czeh, B., & Oomen, C. A. (2009). Do depression, stress, sleep disruption, and inflammation alter hippocampal apoptosis and neurogenesis? In C. M. Pariante (Ed.), Understanding depression: A translational approach. (pp. 139-156). Oxford: Oxford University Press. [details]
  • Lucassen, P. J., Scheper, W., & van Someren, E. J. W. (2009). Adult neurogenesis and the unfolded protein response; new cellular and molecular avenues in sleep research. Sleep Medicine Reviews, 13(3), 183-186. DOI: 10.1016/j.smrv.2008.12.004 [details]
  • Lucassen, P. J., Boekhoorn, K., & Francis, F. (2009). Cortical development - Disorders. In M. D. Binder, N. Hirokawa, & U. Windhorst (Eds.), Encyclopedia of neuroscience. (pp. 894-896). Berlin: Springer. [details]
  • Marlatt, M. W., Hoozemans, J. J. M., Veerhuis, R., & Lucassen, P. J. (2009). Alzheimer’s disease and adult neurogenesis—Are endogenous stem cells part of the solution? US Neurology, 5(1), 12-14. [details]
  • Oomen, C. A., Girardi, C. E. N., Cahyadi, R., Verbeek, E. C., Krugers, H., Joëls, M., & Lucassen, P. J. (2009). Opposite effects of early maternal deprivation on neurogenesis in male versus female rats. PLoS One, 4(1), e3675. DOI: 10.1371/journal.pone.0003675 [details] [PDF]
  • Bao, A. M., Lucassen, P. J., & Swaab, D. F. (2009). Neuroendocrinology of psychiatric disorders. In M. D. Binder, N. Hirokawa, & U. Windhorst (Eds.), Encyclopedia of neuroscience. (pp. 2641-2645). Berlin: Springer. [details]
  • Joosen, M. J. A., Jousma, E., van den Boom, T. M., Kuijpers, W. C., Smit, A. B., Lucassen, P. J., & van Helden, H. P. M. (2009). Long-term cognitive deficits accompanied by reduced neurogenesis after soman poisoning. Neurotoxicology, 30(1), 72-80. DOI: 10.1016/j.neuro.2008.11.010 [details]
  • Swaab, D. F., & Lucassen, P. J. (2009). Drinking disorders and osmoregulation. In M. D. Binder, N. Hirokawa, & U. Windhorst (Eds.), Encyclopedia of neuroscience. (pp. 1010-1014). Berlin: Springer. [details]
  • Swaab, D. F., & Lucassen, P. J. (2009). Hypothalamo-neurohypophysial system. In M. D. Binder, N. Hirokawa, & U. Windhorst (Eds.), Encyclopedia of neuroscience. (pp. 1888-1892). Berlin: Springer. [details]
  • Swaab, D. F., & Lucassen, P. J. (2009). Neuroendocrinology of eating disorders. In M. D. Binder, N. Hirokawa, & U. Windhorst (Eds.), Encyclopedia of neuroscience. (pp. 2635-2637). Berlin: Springer. [details]
  • Swaab, D. F., & Lucassen, P. J. (2009). Neuroendocrinology of tumors. In M. D. Binder, N. Hirokawa, & U. Windhorst (Eds.), Encyclopedia of neuroscience. (pp. 2645-2648). Berlin: Springer. [details]
  • Swaab, D. F., & Lucassen, P. J. (2009). Neuroendocrinology. In M. D. Binder, N. Hirokawa, & U. Windhorst (Eds.), Encyclopedia of neuroscience. (pp. 2631-2635). Berlin: Springer. [details]

2008

  • Boekhoorn, K., Sarabdjitsingh, A., Kommerie, H., de Punder, K., Schouten, T., Lucassen, P. J., & Vreugdenhil, E. (2008). Doublecortin (DCX) and doublecortin-like (DCL) are differentially expressed in the early but not late stages of murine neocortical development. The journal of comparative neurology, 507(4), 1639-1652. DOI: 10.1002/cne.21646 [details]
  • Lucassen, P. J., Oomen, C., van Dam, A-M., & Czéh, B. (2008). Regulation of hippocampal neurogenesis by systemic factors including stress, glucocorticoids, sleep, and inflammation. In F. H. Gage, G. Kempermann, & H. Song (Eds.), Adult neurogenesis. (pp. 363-396). (Cold Spring Harbor monograph series; No. 52). Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press. [details]
  • Marlatt, M. W., Lucassen, P. J., Perry, G., Smith, M. A., & Zhu, X. (2008). Alzheimer's disease: Cerebrovascular dysfunction, oxidative stress, and advanced clinical therapies. Journal of Alzheimer's Disease, 15(2), 199-210. [details] [PDF]
  • Thompson, A., Boekhoorn, K., van Dam, A-M., & Lucassen, P. J. (2008). Changes in adult neurogenesis in neurodegenerative diseases: Cause or consequence? Genes Brain and Behavior, 7(s1), 28-42. DOI: 10.1111/j.1601-183X.2007.00379.x [details]
  • Simic, G., Mladinov, M., Seso Simic, D., Jovanov Milosevic, N., Islam, A., Pajtak, A., ... Kruslin, B. (2008). Abnormal motoneuron migration, differentiation, and axon outgrowth in spinal muscular atrophy. Acta Neuropathologica, 115(3), 313-326. DOI: 10.1007/s00401-007-0327-1 [details]

2014

  • Kuipers, S. D., Bramham, C. R., Cameron, H. A., Fitzsimons, C. P., Korosi, A., & Lucassen, P. J. (2014). Environmental Control of Adult Neurogenesis: From Hippocampal Homeostasis to Behavior and Disease. Neural Plasticity, 2014, 808643. DOI: 10.1155/2014/808643 [details] [PDF]

2015

  • Bolijn, S., & Lucassen, P. J. (2015). How the body talks to the brain; peripheral mediators of physical activity-induced proliferation in the adult hippocampus. Brain Plasticity, 1(1), 5-27. DOI: 10.3233/BPL-150020 [details] [PDF]

2008

  • Lucassen, P. J., Verbeek, E. C., & Oomen, C. A. (2008). Wat doen die nieuwe hersencellen daar? Neurogenese en celdood in volwassen hersenen. BLIND : Interdisciplinair Tijdschrift, 15[details] [PDF]
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