Fotograaf: onbekend

dhr. dr. E.M.M. (Erik) Manders


  • Faculteit der Natuurwetenschappen, Wiskunde en Informatica
    SILS
  • Bezoekadres
    Science Park A
    Science Park 904  Amsterdam
    Kamernummer: C2.102
  • Postadres:
    Postbus  94215
    1090 GE  Amsterdam
  • E.M.M.Manders@uva.nl
    T: 0205256225

Short biography

Erik Manders studied in experimental physics (University of Amsterdam) and did a PhD at the University of Amsterdam in development and applications of multi-color confocal microscopy (1994). During post-doc positions Stockholm and Oxford he focused on building new microscopes and 3D-imaging of living cells. Back in Amsterdam, he patented his invention "Controlled Light Exposure Microscopy" (CLEM) and further developed this technology with his co-workers from the Academic Medical Centre (Amsterdam).

At the moment he is associate professor  at the University of Amsterdam and operational manager of the Van Leeuwenhoek Centre for Advanced Microscopy (UvA). At this moment he leads a small research group and focuses on the development of super-resolution technology that can be used for live-cell imaging. Two techniques are now being developed in his group and find their way to industry and biological applications.

Re-scan Confocal Microscopy (RCM) is a new super-resolution technique that provides improved resolution and strongly improved optical sensitivity.  This improved confocal microscope is based on simple technology and is typically useful for biological applications where the combination of high resolution and high sensitivity is required.

The second technique is Multi-spot Structured Illumination Microscopy (MSIM) which is based on illumination of the sample with a dedicated pattern of spot lights. Interference of this spot-pattern with microscopic structures in the cell provides super-resolution information which can be extracted with image reconstruction techniques.

Together with biologists within and outside the institute, these new techniques are applied in biomedical research. Moreover, within the Nikon Centre of Excellence on Super-Resolution Microscopy the knowledge generated from these projects is transferred towards the industry. 

 

2015

  • Pandey, R., Pieper, G. H., ter Beek, A., Vischer, N. O. E., Smelt, J. P. P. M., Manders, E. M. M., & Brul, S. (2015). Quantifying the effect of sorbic acid, heat and combination of both on germination and outgrowth of Bacillus subtilis spores at single cell resolution. Food Microbiology, 52, 88-96. DOI: 10.1016/j.fm.2015.06.007 [details]
  • Shahi, S., Beerens, B., Manders, E. M. M., & Rep, M. (2015). Dynamics of the establishment of multinucleate compartments in Fusarium oxysporum. Eukaryotic Cell, 14(1), 78-85. DOI: 10.1128/EC.00200-14 [details / files]
  • Smith, R. L., De Vos, W. H., de Boer, R., Manders, E. M. M., & van der Spek, H. (2015). In vivo visualization and quantification of mitochondrial morphology in C. elegans. In V. Weissig, & M. Edeas (Eds.), Mitochondrial medicine. - Vol. 2: Manipulating mitochondrial function. (pp. 367-377). (Methods in molecular biology; No. 1265). New York: Humana Press. DOI: 10.1007/978-1-4939-2288-8_26 [details]
  • de Boer, R., Smith, R. L., De Vos, W. H., Manders, E. M. M., Brul, S., & van der Spek, H. (2015). Caenorhabditis elegans as a Model System for Studying Drug Induced Mitochondrial Toxicity. PLoS One, 10(5), [e0126220]. DOI: 10.1371/journal.pone.0126220 [details] [PDF]
  • Nahidiazar, L., Kreft, M., van den Broek, B., Secades, P., Manders, E. M. M., Sonnenberg, A., & Jalink, K. (2015). The molecular architecture of hemidesmosomes, as revealed with super-resolution microscopy. Journal of Cell Science, 128(20), 3714-3719. DOI: 10.1242/jcs.171892 [details / files]
  • Nieuwenhuizen, R. P. J., Nahidiazar, L., Manders, E. M. M., Jalink, K., Stallinga, S., & Rieger, B. (2015). Co-Orientation: Quantifying Simultaneous Co-Localization and Orientational Alignment of Filaments in Light Microscopy. PLoS One, 10(7), e0131756. DOI: 10.1371/journal.pone.0131756 [details] [PDF]

2014

  • Noam, Y., Ehrengruber, M. U., Koh, A., Feyen, P., Manders, E. M. M., Abbott, G. W., ... Baram, T. Z. (2014). Filamin A promotes dynamin-dependent internalization of hyperpolarization-activated cyclic nucleotide-gated type 1 (HCN1) channels and restricts /h in hippocampal neurons. The Journal of Biological Chemistry, 289(9), 5889-5903. DOI: 10.1074/jbc.M113.522060 [details]
  • Schouten, M., De Luca, G. M. R., Alatriste González, D. K., de Jong, B. E., Timmermans, W., Xiong, H., ... Fitzsimons, C. P. (2014). Imaging dendritic spines of rat primary hippocampal neurons using structured illumination microscopy. Journal of Visualized Experiments, 87, e51276. DOI: 10.3791/51276 [details]
  • Tark-Dame, M., Jerabek, H., Manders, E. M. M., Heermann, D. W., & van Driel, R. (2014). Depletion of the chromatin looping proteins CTCF and cohesin causes chromatin compaction: insight into chromatin folding by polymer modelling. PLoS Computational Biology, 10(10), e1003877. DOI: 10.1371/journal.pcbi.1003877 [details] [PDF]
  • Verbruggen, P., Heinemann, T., Manders, E., von Bornstaedt, G., van Driel, R., & Höfer, T. (2014). Robustness of DNA Repair through Collective Rate Control. PLoS Computational Biology, 10(1), e1003438. DOI: 10.1371/journal.pcbi.1003438 [details] [PDF]

2013

  • De Luca, G. M. R., Breedijk, R. M. P., Brandt, R. A. J., Zeelenberg, C. H. C., de Jong, B. E., Timmermans, W., ... Manders, E. M. M. (2013). Re-scan confocal microscopy: scanning twice for better resolution. Biomedical optics express, 4(11), 2644-2656. DOI: 10.1364/BOE.4.002644 [details / files]
  • Pandey, R., ter Beek, A., Vischer, N. O. E., Smelt, J. P. P. M., Brul, S., & Manders, E. M. M. (2013). Live cell imaging of germination and outgrowth of individual Bacillus subtilis spores; the effect of heat stress quantitatively analyzed with SporeTracker. PLoS One, 8(3), e58972. DOI: 10.1371/journal.pone.0058972 [details] [PDF]

2012

  • Noam, Y., Phan, L., McClelland, S., Manders, E. M., Ehrengruber, M. U., Wadman, W. J., ... Chen, Y. (2012). Distinct regional and subcellular localization of the actin-binding protein filamin A in the mature rat brain. The journal of comparative neurology, 520(13), 3013-3034. DOI: 10.1002/cne.23106 [details]

2011

  • Adjobo-Hermans, M. J. W., Goedhart, J., van Weeren, L., Nijmeijer, S., Manders, E. M. M., Offermanns, S., & Gadella (jr.), T. W. J. (2011). Real-time visualization of heterotrimeric G protein Gq activation in living cells. BMC Biology, 9, 32. DOI: 10.1186/1741-7007-9-32 [details] [PDF]
  • Marlatt, M. W., Philippens, I., Manders, E., Czeh, B., Joëls, M., Krugers, H., & Lucassen, P. J. (2011). Distinct structural plasticity in the hippocampus and amygdala of the middle-aged common marmoset (Callithrix jacchus). Experimental Neurology, 230(2), 291-301. DOI: 10.1016/j.expneurol.2011.05.008 [details]
  • Oomen, C. A., Soeters, H., Audureau, N., Vermunt, L., van Hasselt, F. N., Manders, E. M. M., ... Lucassen, P. J. (2011). Early maternal deprivation affects dentate gyrus structure and emotional learning in adult female rats. Psychopharmacology, 214(1), 249-260. DOI: 10.1007/s00213-010-1922-8 [details] [PDF]
  • Sosinska, G. J., de Koning, L. J., de Groot, P. W. J., Manders, E. M. M., Dekker, H. L., Hellingwerf, K. J., ... Klis, F. M. (2011). Mass spectrometric quantification of the adaptations in the wall proteome of Candida albicans in response to ambient pH. Microbiology - SGM, 157(1), 136-146. DOI: 10.1099/mic.0.044206-0 [details]
  • Weerman, E. J., van der Geest, H. G., van der Meulen, M. D., Manders, E. M. M., van de Koppel, J., Herman, P. M. J., & Admiraal, W. (2011). Ciliates as engineers of phototrophic biofilms. Freshwater Biology, 56(7), 1358-1369. DOI: 10.1111/j.1365-2427.2011.02574.x [details]
  • ter Beek, A., Hornstra, L. M., Pandey, R., Kallemeijn, W. W., Smelt, J. P. P. M., Manders, E. M. M., & Brul, S. (2011). Models of the behaviour of (thermally stressed) microbial spores in foods: Tools to study mechanisms of damage and repair. Food Microbiology, 28(4), 678-684. DOI: 10.1016/j.fm.2010.07.003 [details]
  • De Vos, W. H., Houben, F., Kamps, M., Malhas, A., Verheyen, F., Cox, J., ... Broers, J. L. V. (2011). Repetitive disruptions of the nuclear envelope invoke temporary loss of cellular compartmentalization in laminopathies. Human Molecular Genetics, 20(21), 4175-4186. DOI: 10.1093/hmg/ddr344 [details]
  • De Vylder, J., De Vos, W. H., Manders, E. M., & Philips, W. (2011). 2D mapping of strongly deformable cell nuclei, based on contour matching. Cytometry. Part A, 79A(7), 580-588. DOI: 10.1002/cyto.a.21055 [details]

2010

  • Oomen, C. A., Soeters, H., Audureau, N., Vermunt, L., van Hasselt, F. N., Manders, E. M. M., ... Krugers, H. (2010). Severe early life stress hampers spatial learning and neurogenesis, but improves hippocampal synaptic plasticity and emotional learning under high-stress conditions in adulthood. The Journal of Neuroscience, 30(19), 6635-6645. DOI: 10.1523/JNEUROSCI.0247-10.2010 [details]
  • Tessadori, F., Zeng, K., Manders, E., Riool, M., Jackson, D., & van Driel, R. (2010). Stable S/MAR-based episomal vectors are regulated at the chromatin level. Chromosome Research, 18(7), 757-775. DOI: 10.1007/s10577-010-9165-4 [details] [PDF]
  • Hoebe, R. A., van Noorden, C. J. F., & Manders, E. M. M. (2010). Noise effects and filtering in controlled light exposure microscopy. Journal of Microscopy, 240(3), 197-206. DOI: 10.1111/j.1365-2818.2010.03400.x [details]
  • de Vos, W. H., Houben, F., Hoebe, R. A., Hennekam, R., van Engelen, B., Manders, E. M. M., ... van Oostveldt, P. (2010). Increased plasticity of the nuclear envelope and hypermobility of telomeres due to the loss of A-type lamins. Biochimica et Biophysica Acta G General Subjects, 1800(4), 448-458. DOI: 10.1016/j.bbagen.2010.01.002 [details]
  • de Vos, W. H., Joss, G. H., Haffmans, W., Hoebe, R. A., Manders, E. M. M., & van Oostveldt, P. (2010). Four-dimensional telomere analysis in recordings of living human cells acquired with Controlled Light Exposure. Journal of Microscopy, 238(3), 254-264. DOI: 10.1111/j.1365-2818.2009.03350.x [details]

2009

  • Mateos-Langerak, J., Bohn, M., de Leeuw, W., Giromus, O., Manders, E. M. M., Verschure, P. J., ... Goetze, S. (2009). Spatially confined folding of chromatin in the interphase nucleus. Proceedings of the National Academy of Sciences of the United States of America, 106(10), 3812-3817. DOI: 10.1073/pnas.0809501106 [details]
  • Michielse, C. B., van Wijk, R., Reijnen, L., Manders, E. M. M., Boas, S., Olivain, C., ... Rep, M. (2009). The nuclear protein Sge1 of Fusarium oxysporum is required for parasitic growth. PLoS Pathogens, 5(10), e1000637. DOI: 10.1371/journal.ppat.1000637 [details] [PDF]
  • de Vos, W. H., Hoebe, R. A., Joss, G. H., Haffmans, W., Baatout, S., van Oostveldt, P., & Manders, E. M. M. (2009). Controlled light exposure microscopy reveals dynamic telomere microterritories throughout the cell cycle. Cytometry. Part A, 75A(5), 428-439. DOI: 10.1002/cyto.a.20699 [details]

2008

  • Hoebe, R. A., van der Voort, H. T. M., Stap, J., van Noorden, C. J. F., & Manders, E. M. M. (2008). Quantitative determination of the reduction of phototoxicity and photobleaching by controlled light exposure microscopy. Journal of Microscopy, 231(1), 9-20. DOI: 10.1111/j.1365-2818.2008.02009.x [details]
  • Pereira-Cenci, T., Deng, D. M., Kraneveld, E. A., Manders, E. M. M., Del Bel Cury, A. A., ten Cate, J. M., & Crielaard, W. (2008). The effect of Streptococcus mutans and Candida glabrata on Candida albicans biofilms formed on different surfaces. Archives of Oral Biology, 53(8), 755-764. DOI: 10.1016/j.archoralbio.2008.02.015 [details]
  • van der Does, H. C., Duyvesteijn, R. G. E., Goltstein, P. M., van Schie, C. C. N., Manders, E. M. M., Cornelissen, B. J. C., & Rep, M. (2008). Expression of effector gene SIX1 of Fusarium oxysporum requires living plant cells. Fungal Genetics and Biology, 45(9), 1257-1264. DOI: 10.1016/j.fgb.2008.06.002 [details] [PDF]
  • de Vos, W. H., Hoebe, R. A., Joss, G., Manders, E., & van Oostveldt, P. (2008). Controlled light exposure microscopy reveals telomeric microterritories throughout the cell cycle. In A. Aretz, B. Hermanns-Sachweh, & J. Mayer (Eds.), EMC 2008: 14th European Microscopy Congress, 1-5 September 2008, Aachen, Germany: Volume 3: Life science. (pp. 169-170). Berlin: Springer. DOI: 10.1007/978-3-540-85228-5_85 [details]

2007

  • Hoebe, R. A., van Oven, C. H., Gadella, T. W. J., Dhonukshe, P. B., van Noorden, C. J. F., & Manders, E. M. M. (2007). Controlled light-exposure microscopy reduces photobleaching and phototoxicity in fluorescence live-cell imaging. Nature Biotechnology, 25(2), 249-253. DOI: 10.1038/nbt1278 [details]
  • van Munster, E. B., Goedhart, J., Kremers, G. J., Manders, E. M. M., & Gadella, T. W. J. (2007). Combination of a spinning disc confocal unit with frequency-domain fluorescence lifetime imaging microscopy. Cytometry. Part A, 71(4), 207-214. DOI: 10.1002/cyto.a.20379 [details]

2006

  • Manders, E. M. M., Soll, D. R., Terasaki, M., & Dailey, M. E. (2006). Confocal microscopy of living cells. In J. Pawley (Ed.), Handbook of confocal microscopy, third edition.. New York, USA: Springer Science and Business Media. [details]

2005

  • Cremazy, F. G. E., Manders, E. M. M., Bastiaens, P. I. H., Kramer, G., Hager, G. L., van Munster, E. B., ... van Driel, R. (2005). Imaging in situ protein-DNA interactions in the cell nucleus using FRET-FLIM. Experimental Cell Research, 309, 390-396. DOI: 10.1016/j.yexcr.2005.06.007 [details]

2004

  • Barranguet, C., van Beusekom, S. A. M., Veugel, B., Neu, T. R., Manders, E. M. M., Sinke, J. J., & Admiraal, W. (2004). Studying undisturbed autotrophic biofilms: still a technical challange. Aquatic Microbial Ecology, 34, 1-9. DOI: 10.3354/ame034001 [details]
  • Barranguet, C., van Beusekom, S. A. M., Veuger, B., Neu, T. R., Sinke, J. J., Admiraal, W., & Manders, E. M. M. (2004). Studying undisturbed autotrophic biofilms: still a technical challenge. Aquatic Microbial Ecology, 34(1), 1-9. DOI: 10.3354/ame034001 [details]
  • Moné, M. J., Bernas, T., Dinant, C., Goedvree, F. A., Manders, E. M. M., Volker, M., ... van Driel, R. (2004). In vivo dynamics of chromatin-associated complex formation in mammalian nucleotide excision repair. Proceedings of the National Academy of Sciences of the United States of America, 101, 15933-15937. DOI: 10.1073/pnas.0403664101 [details]

2003

  • Manders, E. M. M., Visser, A. E., Koppen, A., de Leeuw, W. C., van Liere, R., Brakenhoff, G. J., & van Driel, R. (2003). Four-dimensional imaging of chromatin dynamics during the assembly of the interphase nucleus. Chromosome Research, 11, 537-547. DOI: 10.1023/A:1024995215340 [details]
  • Verschure, P. J., van der Kraan, K., Manders, E. M. M., Hoogstraten, D., Houtsmuller, A. B., & van Driel, R. (2003). Condensed chromatin domains in the mammalian nucleus are accessible to large macromolecules. EMBO Reports, 4, 861-866. DOI: 10.1038/sj.embor.embor922 [details]

2002

  • Verschure, P. J., van der Kraan, I., Enserink, J. M., Moné, M. J., Manders, E. M. M., & van Driel, R. (2002). Large-scale chromatin organization and the localization of proteins involved in gene expression in human cells. The Journal of Histochemistry and Cytochemistry, 50, 1303-1312. DOI: 10.1177/002215540205001003 [details]

2001

  • Bergsma, C. B. J., Streekstra, G. J., Smeulders, A. W. M., & Manders, E. M. M. (2001). Velocity estimation of spots in three-dimensional confocal image sequences of living cells. Cytometry, 43, 261-272. DOI: 10.1002/1097-0320(20010401)43:4<261::AID-CYTO1058>3.0.CO;2-D [details]
  • Moné, M. J., Volker, M., Nikaido, O., Mullenders, L. H. F., van Zeeland, A. A., Verschure, P. J., ... van Driel, R. (2001). Local UV induced DNA damage in cell nuclei results in local transcription inhibition. EMBO Reports, 2, 1013-1017. DOI: 10.1093/embo-reports/kve224 [details]
  • Takebayashi, S. I., Manders, E. M. M., Kimura, H., Taguchi, H., & Okumura, K. (2001). Mapping sites where replication initiates in mammalian cells using DNA fibers. Experimental Cell Research, 271, 263-268. DOI: 10.1006/excr.2001.5389 [details]
  • Visser, H. P. J., Gunster, M. J., Kluin-Nelemans, H. C., Manders, E. M. M., Raaphorst, F. M., Meijer, C. J. L. M., ... Otte, A. P. (2001). The polycomb group protein EZH2 is upregulated in proliferating, cultured human mantle cell lymphoma. British journal of haematology, 112, 950-958. DOI: 10.1046/j.1365-2141.2001.02641.x [details]

2000

  • Visser, H. P. J., Gunster, M. J., Otte, A. P., Manders, E. M. M., Raaphorst, F. M., Willemze, R., & Kluin-Nelemans, H. C. (2000). Upregulation of the polycomb group protein EZH2 in proliferating, cultured mantle cell lymphoma. Blood, 96, 3004. [details]

1999

  • Broers, J. L. V., Machiels, B. M., van Eys, G. J. J. M., Kuijpers, H. J. H., Manders, E. M. M., van Driel, R., & Ramaekers, F. C. S. (1999). Dynamics of nuclear lamina as monitored by GFP-tagged A-type lamins. Journal of Cell Science, 112, 3463-3475. [details]

2015

  • Pandey, R., ter Beek, A., Vischer, N. O. E., Smelt, J. P. P. M., Kemperman, R., Manders, E. M. M., & Brul, S. (2015). Quantitative analysis of the effect of specific tea compounds on germination and outgrowth of Bacillus subtilis spores at single cell resolution. Food Microbiology, 45(A), 63-70. DOI: 10.1016/j.fm.2014.03.006 [details]

2000

  • Bergsma, C. B. J., Streekstra, G. J., Smeulders, A. W. M., & Manders, E. M. M. (2000). Velocity Estimation of Spots in 3D Confocal Image Sequeces of Living Cells. (ISIS Tecn. Rep.; No. Rep. 23). Amsterdam: Informatics Institute. [details]
This list of publications is extracted from the UvA-Current Research Information System. Questions? Ask the library or the Pure staff of your faculty / institute. Log in to Pure to edit your publications.
  • Universiteit van Gent
    Gast professor
  • Stichting Focus on Microscopy
    Penningmeester en secretaris
  • RCM B.V.
    Marktonderzoek en publiciteit
  • Confocal.nl B.V.
    Scientific director

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