Fotograaf: onbekend

dhr. dr. E.M.M. (Erik) Manders

  • Faculteit der Natuurwetenschappen, Wiskunde en Informatica
  • Bezoekadres
    Science Park A
    Science Park 904  Amsterdam
    Kamernummer: C2.102
  • Postadres:
    Postbus  94215
    1090 GE  Amsterdam
    T: 0205256225

Short biography

Erik Manders studied in experimental physics (University of Amsterdam) and did a PhD at the University of Amsterdam in development and applications of multi-color confocal microscopy (1994). During post-doc positions Stockholm and Oxford he focused on building new microscopes and 3D-imaging of living cells. Back in Amsterdam, he patented his invention "Controlled Light Exposure Microscopy" (CLEM) and further developed this technology with his co-workers from the Academic Medical Centre (Amsterdam).

At the moment he is associate professor  at the University of Amsterdam and operational manager of the Van Leeuwenhoek Centre for Advanced Microscopy (UvA). At this moment he leads a small research group and focuses on the development of super-resolution technology that can be used for live-cell imaging. Two techniques are now being developed in his group and find their way to industry and biological applications.

Re-scan Confocal Microscopy (RCM) is a new super-resolution technique that provides improved resolution and strongly improved optical sensitivity.  This improved confocal microscope is based on simple technology and is typically useful for biological applications where the combination of high resolution and high sensitivity is required.

The second technique is Multi-spot Structured Illumination Microscopy (MSIM) which is based on illumination of the sample with a dedicated pattern of spot lights. Interference of this spot-pattern with microscopic structures in the cell provides super-resolution information which can be extracted with image reconstruction techniques.

Together with biologists within and outside the institute, these new techniques are applied in biomedical research. Moreover, within the Nikon Centre of Excellence on Super-Resolution Microscopy the knowledge generated from these projects is transferred towards the industry. 












  • E.M.M. Manders, D.R. Soll, M. Terasaki & M.E. Dailey (2006). Confocal microscopy of living cells. In J. Pawley (Ed.), Handbook of confocal microscopy, third edition. New York, USA: Springer Science and Business Media.







  • H.P.J. Visser, M.J. Gunster, A.P. Otte, E.M.M. Manders, F.M. Raaphorst, R. Willemze & H.C. Kluin-Nelemans (2000). Upregulation of the polycomb group protein EZH2 in proliferating, cultured mantle cell lymphoma. Blood, 96, 3004.
  • C.B.J. Bergsma, G.J. Streekstra, A.W.M. Smeulders & E.M.M. Manders (2000). Velocity Estimation of Spots in 3D Confocal Image Sequeces of Living Cells. (intern rapport, ISIS Tecn. Rep., no Rep. 23). Amsterdam: Informatics Institute.


  • J.L.V. Broers, B.M. Machiels, G.J.J.M. van Eys, H.J.H. Kuijpers, E.M.M. Manders, R. van Driel & F.C.S. Ramaekers (1999). Dynamics of nuclear lamina as monitored by GFP-tagged A-type lamins. Journal of Cell Science, 112, 3463-3475.


  • R. van Driel, E.M.M. Manders, L. de Jong, J. Stap & J.A. Aten (1998). Mapping of DNA replication sites in situ by fluorescence microscopy. Methods in Cell Biology, 53, 455-469.


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  • Universiteit van Gent
    Gast professor
  • Stichting Focus on Microscopy
    Penningmeester en secretaris
  • RCM B.V.
    Marktonderzoek en publiciteit
  • B.V.
    Scientific director

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