dhr. prof. dr. S. (Stanley) Brul

Lijst

Faculteit der Natuurwetenschappen, Wiskunde en Informatica
SILS
POSTBUS 94232
1090 GE Amsterdam
Kamernummer: C3.263
S.Brul@uva.nl
T: 0205257079
T: 0205256970

Research & Education
Publicaties
Nevenwerkzaamheden

International Scholarship Project

Current open Chinese Science Council Project

een kijkje binnen in onze 'levende cellen' A view of molecular movement and interactions within our 'living cells'

Bio-medische Wetenschappen Universiteit van Amsterdam

prof. dr. Stanley Brul Opleidingsdirecteur: MELD JE NU AAN ER IS EEN NUMERUS FIXUS!

De behandeling van kanker, het opsporen van ziektes bij ongeboren kinderen, de speurtocht naar een vaccin tegen aids: het werkterrein van de bio-medische wetenschapper bevindt zich in de frontlinie van de medische wetenschap. Als specialist in de moleculaire basis van leven zijn de onderzoeksresultaten vaak van levensreddende betekenis . Ook kun je met deze studie als expert of hoofd van het diagnostische laboratorium van ziekenhuizen gaan werken. Aansluiting is er voor de hele goede en gemotiveerde student op selectieve research masterprogramma's Biomedical Sciences, de arts-onderzoekers masters AKO (Maastricht) en SUMMA (Utrecht) alsmede het Geneeskunde masters programa met onderzoekersprofiel van VUMC en de zij-instroom van de masters Geneeskunde van het AMC. Deze opleiding wordt aan de UvA gezamenlijk gedragen door de bètafaculteit en het AMC.

http://www.uva.nl/onderwijs/bachelor/bacheloropleidingen/content/bio-medische-wetenschappen/maak-kennis-met-ons/docenten/stanley-brul.html

Numerus fixus & Geneeskunde. Bio-medische wetenschappen aan de UvA staat voor kwaliteit op theoretisch en praktischvlak. Vanuit die insteek hebben we vanaf 2011 gekozen voor een numerusfixus die inmiddels landelijk is. Onze numerus fixus staat op 200. Eerste keus inschrijvers met een gemiddeld eindexamencijfer van 8 of hoger hebben daarbij altijd een plek. Alle vroege inschrijvers, i.e. zij die zich per 15 mei hebben aangemeld, hebben BIJNA ZEKER een plaats. Wees er dus snel bij! Hieronder staat een korte introductie op datgene wat op de bachelordag van a.s. zaterdag 16 november 2013 aan bod komt en twee highlight (thema)colleges van de opleiding.

Bio-medische wetenschappen bachelordag 8 maart 2014

Highlight colleges

Deze links geven highlight colleges over pathogene schimmels (prof. Brul), waarin microbiologie en gastheer-microbe interacties centraal staan, en over aangeboren en verworven metabole ziekten (prof. Aerts) zoals ze op het AMC worden bestudeerd. De colleges zijn er twee uit een reeks en geven een prachtige illustratie hoe de fundamentele inzichten in de biologie van het menselijk lichaam en microorganismen essentieel zijn om tot goede therapie van ziekten en het, met gerichte interventies, behouden van gezondheid te komen.

Pathogene schimmels om ons heen

Ziekten van ons metabolisme

eiwitsynthese in cellen op ware snelheid

celdeling principe

celgroei en deling van gistcellen

celdeling van longcellen

groei en sporulatie (groen fluorescerende delen) van een bacterie kolonie (wel 100 miljoen cellen)

Masters Biomedical Sciences UvA

Information on the Masters program as well as current curriculum updates.

http://www.uva.nl/en/education/master-s/master-s-programmes/item/biomedical-sciences.html

http://www.uva.nl/en/education/master-s/master-s-programmes/content/biomedical-sciences-medical-biology/medical-biology.html

track Biochemistry&Metabolic Diseases

http://www.uva.nl/en/education/master-s/master-s-programmes/content/biomedical-sciences-medical-biology/study-programme/biochemistry-and-metabolic-diseases.html

Our Research group Molecular Biology&Microbial Food Safety

Thislinkprovides entry to the web-site of our researchgroup at theSwammerdam Institutefor Life Sciences of the Faculty of Sience

http://sils.uva.nl/research#anker-molecular-biology-and-microbial-food-safety

Scientific consulting, courses, workshops and translations

Lombardo Consulting services

http://mariellalombardo.com/aboutme.html

refereed(47)
wetenschappelijk(14)
populair wetenschappelijk(1)

2014

F.M. Klis, C.G. de Koster & S. Brul (2014). Cell Wall-Related Bionumbers and Bioestimates of Saccharomyces cerevisiae and Candida albicans. Eukaryotic Cell, 13 (1), 2-9. doi: 10.1128/EC.00250-13
Y. Feng, N. Händel, M.H.P. de Groot, S. Brul, C. Schultsz & B.H. ter Kuile (2014). Experimental Simulation of the Effects of an Initial Antibiotic Treatment on a Subsequent Treatment after Initial Therapy Failure. Antibiotics, 3 (1), 49-63. doi: 10.3390/antibiotics3010049

2013

J.P. Smelt, S.C. Stringer & S. Brul (2013). Behaviour of individual spores of non proteolytic Clostridium botulinum as an element in quantitative risk assessment. Food Control, 29 (2), 358-363. doi: 10.1016/j.foodcont.2012.04.021
W. Abhyankar, A.H. Hossain, A. Djajasaputra, P. Permpoonpattana, A. ter Beek, H.L. Dekker, S.M. Cutting, S. Brul, L.J. de Koning & C.G. de Koster (2013). In pursuit of protein targets: proteomic characterization of bacterial spore outer layers. Journal of Proteome Research, 12 (10), 4507-4521. doi: 10.1021/pr4005629
A.G. Sorgo, C.J. Heilmann, S. Brul, C.G. de Koster & F.M. Klis (2013). Beyond the wall: Candida albicans secret(e)s to survive. FEMS Microbiology Letters, 338 (1), 10-17. doi: 10.1111/1574-6968.12049
M.A. van der Horst, T.H. Fabri, J.M. Schuurmans, B.B. Koenders, S. Brul & B.H. ter Kuile (2013). Effects of therapeutical and reduced levels of antibiotics on the fraction of antibiotic-resistant strains of Escherichia coli in the chicken gut. Foodborne Pathogens and Disease, 10 (1), 55-61. doi: 10.1089/fpd.2012.1217[go to publisher's site]
R. Pandey, A. ter Beek, N.O. Vischer, J.P.P.M. Smelt, S. Brul & E.M.M. Manders (2013). Live cell imaging of germination and outgrowth of individual Bacillus subtilis spores; the effect of heat stress quantitatively analyzed with SporeTracker. PLoS One, 8 (3), e58972. doi: 10.1371/journal.pone.0058972[go to publisher's site]
N. Händel, J.M. Schuurmans, S. Brul & B.H. ter Kuile (2013). Compensation of the metabolic costs of antibiotic resistance by physiological adaptation in Escherichia coli. Antimicrobial Agents and Chemotherapy, 57 (8), 3752-3762. doi: 10.1128/AAC.02096-12
A.G. Sorgo, S. Brul, C.G. de Koster, L.J. de Koning & F.M. Klis (2013). Iron restriction-induced adaptations in the wall proteome of Candida albicans. Microbiology - SGM, 159 (8), 1673-1682. doi: 10.1099/mic.0.065599-0
J.W.A. van Beilen & S. Brul (2013). Compartment-specific pH monitoring in Bacillus subtilis using fluorescent sensor proteins: a tool to analyze the antibacterial effect of weak organic acids. Frontiers in Microbiology, 4, 157. doi: 10.3389/fmicb.2013.00157[go to publisher's site]
C.J. Heilmann, A.G. Sorgo, S. Mohammadi, G.J. Sosinska, C.G. de Koster, S. Brul, L.J. de Koning & F.M. Klis (2013). Surface stress induces a conserved cell wall stress response in the pathogenic fungus Candida albicans. Eukaryotic Cell, 12 (2), 254-264. doi: 10.1128/EC.00278-12
B. ter Kuile & S. Brul (2013). Antibiotic resistance development and identification of response measures. In J. Sofos (Ed.), Advances in microbial food safety: volume 1 (Woodhead Publishing series in food science, technology and nutrition, 259) (pp. 157-169). Cambridge: Woodhead Publishing.
F.I.C. Mensonides, K.J. Hellingwerf, M.J. Teixeira De Mattos & S. Brul (2013). Multiphasic adaptation of the transcriptome of Saccharomyces cerevisiae to heat stress. Food research international, 54 (1), 1103-1112. doi: 10.1016/j.foodres.2012.12.042
R.L. Smith, R. de Boer, S. Brul, Y. Budovskaya & H. van der Spek (2013). Premature and accelerated aging: HIV or HAART? Frontiers in Genetics, 3, 328. doi: 10.3389/fgene.2012.00328
A. Ullah, G. Chandrasekaran, S. Brul & G.J. Smits (2013). Yeast adaptation to weak acids prevents futile energy expenditure. Frontiers in Microbiology, 4, 142. doi: 10.3389/fmicb.2013.00142[go to publisher's site]
A. Ullah, M.I. Lopes, S. Brul & G.J. Smits (2013). Intracellular pH homeostasis in Candida glabrata in infection-associated conditions. Microbiology - SGM, 159 (4), 803-813. doi: 10.1099/mic.0.063610-0

2012

J. Postmus, R. Aardema, L.J. de Koning, C.G. de Koster, S. Brul & G.J. Smits (2012). Isoenzyme expression changes in response to high temperature determine the metabolic regulation of increased glycolytic flux in yeast. FEMS Yeast Research, 12, 571-581. doi: 10.1111/j.1567-1364.2012.00807.x
R. Orij, M.L. Urbanus, F.J. Vizeacoumar, G. Giaever, C. Boone, C. Nislow, S. Brul & G.J. Smits (2012). Genome-wide analysis of intracellular pH reveals quantitative control of cell division rate by pHc in Saccharomyces cerevisiae. Genome Biol, 13 (9):R80. doi: 10.1186/gb-2012-13-9-r80[go to publisher's site]
S. Brul, J. Basset, P. Cook, S. Kathariou, P. McClure, P.R. Jasti & R. Betts (2012). ‘Omics’ technologies in quantitative microbial risk assessment. Trends in Food Science & Technology, 27 (1), 12-24. doi: 10.1016/j.tifs.2012.04.004
A. Ullah, R. Orij, S. Brul & G.J. Smits (2012). Quantitative analysis of the modes of growth inhibition by weak organic acids in Saccharomyces cerevisiae. Applied and Environmental Microbiology, 78 (23), 8377-8387. doi: 10.1128/AEM.02126-12

2011

M.P.M. Caspers, F.H.J. Schuren, A.C.M. van Zuijlen, S. Brul, R.C. Montijn, T. Abee & R. Kort (2011). A mixed-species microarray for identification of food spoilage bacilli. Food Microbiology, 28 (2), 245-251. doi: 10.1016/j.fm.2010.03.010
A. ter Beek, L.M. Hornstra, R. Pandey, W.W. Kallemeijn, J.P.P.M. Smelt, E.M.M. Manders & S. Brul (2011). Models of the behaviour of (thermally stressed) microbial spores in foods: Tools to study mechanisms of damage and repair. Food Microbiology, 28 (4), 678-684. doi: 10.1016/j.fm.2010.07.003
R. Orij, S. Brul & G.J. Smits (2011). Intracellular pH is a tightly controlled signal in yeast. Biochimica et Biophysica Acta G General Subjects, 1810 (10), 933-944. doi: 10.1016/j.bbagen.2011.03.011
C.J. Heilmann, A.G. Sorgo, A.R. Siliakus, H.L. Dekker, S. Brul, C.G. de Koster, L.J. de Koning & F.M. Klis (2011). Hyphal induction in the human fungal pathogen Candida albicans reveals a characteristic wall protein profile. Microbiology - SGM, 157 (8), 2297-2307. doi: 10.1099/mic.0.049395-0
A.G. Sorgo, C.J. Heilmann, H.L. Dekker, M. Bekker, S. Brul, C.G. de Koster, L.J. de Koning & F.M. Klis (2011). Effects of fluconazole on the secretome, the wall proteome, and wall integrity of the clinical fungus Candida albicans. Eukaryotic Cell, 10 (8), 1071-1081. doi: 10.1128/EC.05011-11
F.M. Klis, C.G. de Koster & S. Brul (2011). A mass spectrometric view of the fungal wall proteome. Future Microbiology, 6 (8), 941-951. doi: 10.2217/fmb.11.72
S. Brul, J. van Beilen, M. Caspers, A. O'Brien, C. de Koster, S. Oomes, J. Smelt, R. Kort & A. ter Beek (2011). Challenges and advances in systems biology analysis of Bacillus spore physiology; molecular differences between an extreme heat resistant spore forming Bacillus subtilis food isolate and a laboratory strain. Food Microbiology, 28 (2), 221-227. doi: 10.1016/j.fm.2010.06.011
A. Zakrzewska, G. van Eikenhorst, J.E.C. Burggraaff, D.J. Vis, H. Hoefsloot, D. Delneri, S.G. Oliver, S. Brul & G.J. Smits (2011). Genome-wide analysis of yeast stress survival and tolerance acquisition to analyze the central trade-off between growth rate and cellular robustness. Molecular Biology of the Cell, 22 (22), 4435-4446. doi: 10.1091/mbc.E10-08-0721
J. Postmus, I. Tuzun, M. Bekker, W.H. Muller, M.J. Teixeira De Mattos, S. Brul & G.J. Smits (2011). Dynamic regulation of mitochondrial respiratory chain efficiency in Saccharomyces cerevisiae. Microbiology - SGM, 157 (12), 3500-3511. doi: 10.1099/mic.0.050039-0
W. Abhyankar, A. ter Beek, H. Dekker, R. Kort, S. Brul & C.G. de Koster (2011). Gel-free proteomic identification of the Bacillus subtilis insoluble spore coat protein fraction. PROTEOMICS, 11, 4541-4550. doi: 10.1002/pmic.201100003

2010

A.H. Havelaar, S. Brul, A. de Jong, R. de Jonge, M.H. Zwietering & B.H. ter Kuile (2010). Future challenges to microbial food safety. International Journal of Food Microbiology, 139 (S1), S79-S94. doi: 10.1016/j.ijfoodmicro.2009.10.015
F.M. Klis, S. Brul & P.W.J. de Groot (2010). Covalently linked wall proteins in ascomycetous fungi. Yeast, 27 (8), 489-493. doi: 10.1002/yea.1747
A. van Zuijlen, P.M. Periago, A. Amézquita, A. Palop, S. Brul & P.S. Fernández (2010). Characterization of Bacillus sporothermodurans IC4 spores; putative indicator microorganism for optimisation of thermal processes in food sterilisation. Food research international, 43 (7), 1895-1901. doi: 10.1016/j.foodres.2009.11.011
A. Zakrzewska, A. Boorsma, A. ter Beek, J.A. Hageman, J.A. Westerhuis, K.J. Hellingwerf, S. Brul, F.M. Klis & G.J. Smits (2010). Comparative analysis of transcriptome and fitness profiles reveals general and condition-specific cellular functions involved in adaptation to environmental change in Saccharomyces cerevisiae. Omics, 14 (5), 603-614. doi: 10.1089/omi.2010.0049[go to publisher's site]
K. van Eunen, J. Bouwman, P. Daran-Lapujade, J. Postmus, A.B. Canelas, F.I.C. Mensonides, R. Orij, I. Tuzun, J. van den Brink, G.J. Smits, W.M. van Gulik, S. Brul, J.J. Heijnen, J.H. de Winde, M.J. Teixeira De Mattos, C. Kettner, J. Nielsen, H.V. Westerhoff & B.M. Bakker (2010). Measuring enzyme activities under standardized in vivo-like conditions for systems biology. The FEBS Journal, 277 (3), 749-760. doi: 10.1111/j.1742-4658.2009.07524.x
A.G. Sorgo, C.J. Heilmann, H.L. Dekker, S. Brul, C.G. de Koster & F.M. Klis (2010). Mass spectrometric analysis of the secretome of Candida albicans. Yeast, 27 (8), 661-672. doi: 10.1002/yea.1775

2009

T. Shen, A.P. Bos & S. Brul (2009). Assessing freeze-thaw and high pressure low temperature induced damage to Bacillus subtilis cells with flow cytometry. Innovative Food Science & Emerging Technologies, 10 (1), 9-15.
R. Orij, J. Postmus, A. ter Beek, S. Brul & G.J. Smits (2009). In vivo measurement of cytosolic and mitochondrial pH using a pH-sensitive GFP derivative in Saccharomyces cerevisiae reveals a relation between intracellular pH and growth. Microbiology - SGM, 155 (1), 268-278.
L.M. Hornstra, A. ter Beek, J.P. Smelt, W.W. Kallemeijn & S. Brul (2009). On the origin of heterogeneity in (preservation) resistance of Bacillus spores: Input for a ‘systems’ analysis approach of bacterial spore outgrowth. International Journal of Food Microbiology, 134 (1-2), 9-15.
S.J.C.M. Oomes, M.J. Jonker, F.R.A. Wittink, J.O. Hehenkamp, T.M. Breit & S. Brul (2009). The effect of calcium on the transcriptome of sporulating B. subtilis cells. International Journal of Food Microbiology, 133 (3), 234-242.
F.M. Klis, G.J. Sosinska, P.W.J. de Groot & S. Brul (2009). Covalently linked cell wall proteins of Candida albicans and their role in fitness and virulence. FEMS Yeast Research, 9 (7), 1013-1028.
A.C.M. van Zuijlen, S.J.C.M. Oomes, P. Vos & S. Brul (2009). Detecting bacterial spores in soup manufacturing. New Food, 21-24.

2008

S. Brul, W. Kallemeijn & G. Smits (2008). Functional genomics for food microbiology: Molecular mechanisms of weak organic acid preservative adaptation in yeast. Perspectives in Agriculture, Veterinary Science, Nutrition and Natural Resources, 3, 005.
J. Postmus, A.B. Canelas, J. Bouwman, B.M. Bakker, W. van Gulik, M.J. Teixeira De Mattos, S. Brul & G.J. Smits (2008). Quantitative analysis of the high temperature-induced glycolytic flux increase in Saccharomyces cerevisiae reveals dominant metabolic regulation. The Journal of Biological Chemistry, 283 (35), 23524-23532.
S. Brul, F.I.C. Mensonides, K.J. Hellingwerf & M.J. Teixeira De Mattos (2008). Microbial systems biology: New frontiers open to predictive microbiology. International Journal of Food Microbiology, 128 (1), 16-21.
J.P.P.M. Smelt, A.P. Bos, R. Kort & S. Brul (2008). Modelling the effect of sub(lethal) heat treatment of Bacillus subtilis spores on germination rate and outgrowth to exponentially growing vegetative cells. International Journal of Food Microbiology, 128 (1), 34-40.
A. ter Beek, B.J.F. Keijser, A. Boorsma, A. Zakrzewska, R. Orij, G.J. Smits & S. Brul (2008). Transcriptome analysis of sorbic acid-stressed Bacillus subtilis reveals a nutrient limitation response and indicates plasma membrane remodeling. Journal of Bacteriology, 190 (5), 1751-1761.

2015

A. ter Beek, J.G.E. Wijman, A. Zakrzewska, R. Orij, G.J. Smits & S. Brul (in press). Comparative physiological and transcriptional analysis of weak organic acid stress in Bacillus subtilis. Food Microbiology, 45 (A), 71-82. doi: 10.1016/j.fm.2014.02.013
R. Pandey, A. ter Beek, N.O.E. Vischer, J.P.P.M. Smelt, R. Kemperman, E.M.M. Manders & S. Brul (in press). Quantitative analysis of the effect of specific tea compounds on germination and outgrowth of Bacillus subtilis spores at single cell resolution. Food Microbiology, 45 (A), 63-70. doi: 10.1016/j.fm.2014.03.006
J.P. Smelt, H.C. Hoefsloot, C.G. de Koster, J.M. Schuurmans, B.H. ter Kuile & S. Brul (in press). Simulation of the rate of transfer of antibiotic resistance between Escherichia coli strains cultured under well controlled environmental conditions. Food Microbiology, 45 (B), 189-194. doi: 10.1016/j.fm.2014.03.019
W. Abhyankar, R. Pandey, A. ter Beek, S. Brul, L.J. de Koning & C.G. de Koster (in press). Reinforcement of Bacillus subtilis spores by cross-linking of outer coat proteins during maturation. Food Microbiology, 45 (A), 54-62. doi: 10.1016/j.fm.2014.03.007

2014

J.P.P.M. Smelt & S. Brul (2014). Thermal inactivation of microorganisms. Critical Reviews in Microbiology, 54 (10), 1371-1385. doi: 10.1080/10408398.2011.637645
F.I.C. Mensonides, S. Brul, K.J. Hellingwerf, B.M. Bakker & M.J. Teixeira De Mattos (2014). A kinetic model of catabolic adaptation and protein reprofiling in Saccharomyces cerevisiae during temperature shifts. The FEBS Journal, 281 (3), 825-841. doi: 10.1111/febs.12649
J.M. Schuurmans, S.A.F.T. van Hijum, J.R. Piet, N. Händel, J. Smelt, S. Brul & B.H. ter Kuile (2014). Effect of growth rate and selection pressure on rates of transfer of an antibiotic resistance plasmid between E. coli strains. Plasmid, 72, 1-8. doi: 10.1016/j.plasmid.2014.01.002
S. Brul (2014). An introduction to Molecular Biology (Omics) in Food Microbiology. In C.A. Batt & M.L. Tortorello (Eds.), Encyclopedia of food microbiology. - 2nd edition. - Vol. 2 (pp. 759-769). Amsterdam: Elsevier.
W. Abhyankar, L.J. de Koning, S. Brul & C.G. de Koster (2014). Spore Proteomics: The Past, Present and the Future. FEMS Microbiology Letters, 358 (2), 137-144. doi: 10.1111/1574-6968.12568
J.W.A. van Beilen, M.J. Teixeira De Mattos, K.J. Hellingwerf & S. Brul (2014). Distinct Effects of Sorbic Acid and Acetic Acid on the Electrophysiology and Metabolism of Bacillus subtilis. Applied and Environmental Microbiology, 80 (19), 5918-5926. doi: 10.1128/AEM.01391-14[go to publisher's site]
N. Händel, J.M. Schuurmans, Y. Feng, S. Brul & B.H. ter Kuile (2014). Interaction between Mutations and Regulation of Gene Expression during Development of de novo Antibiotic Resistance. Antimicrobial Agents and Chemotherapy, 58 (8), 4371-4379. doi: 10.1128/AAC.02892-14[go to publisher's site]

2011

S. Brul (2011, June 26). Covalently linked wall proteins in Candida albicans: pH-dependent expression and candidates for vaccine development. Geneve, Switzerland, 4th FEMS Congress of European Microbiologists.
P.W.J. de Groot, S. Brul & F.M. Klis (2011). Exploring the fungal wall glycoproteome. (vol. 4: Essential reviews in experimental biology). In SA Brooks, PM Rudd & BJ Appelmelk (Eds.), Glycosylation in Diverse Cell Systems: Challenges and New Frontiers in Experimental Glycobiology (pp. 118-138). London, UK: The Society for Experimental Biology.
I. Klei, M. Veenhuis, S. Brul, F.M. Klis, P.W.J. de Groot, W.H. Müller, K.G.A. van Driel & T. Boekhout (2011). Cytology, Cell Walls and septa: A Summary of Yeast Cell Biology from a Phylogenetic Perspective. In C..P. Kurtzman, J..W. Fell & T. Boekhout (Eds.), The Yeasts, a Taxonomic Study, Volume 1 (pp. 111-128). London: Elsevier.

2011

S. Brul (2011, March 20). Hoe werken mijn spieren? NEMO, Amsterdam, The Netherlands, Wakker Worden Kinderlezing.

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