prof. dr. H.V. (Hans) Westerhoff
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Faculty of Science
SILS
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POSTBUS
94215
1090 GE Amsterdam
Room number: C2.103
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H.V.Westerhoff@uva.nl
T: 0205255150
2013
- M. Verma, M. Zakhartsev, M. Reuss & H.V. Westerhoff (2013). 'Domino' systems biology and the 'A' of ATP. Biochimica et Biophysica Acta - Bioenergetics, 1827 (1), 19-29. doi: 10.1016/j.bbabio.2012.09.014
- A. Kolodkin, N. Sahin, A. Phillips, S.R. Hood, F.J. Bruggeman, H.V. Westerhoff & N. Plant (2013). Optimization of stress response through the nuclear receptor-mediated cortisol signalling network. Nature Communications, 4, 1792. doi: 10.1038/ncomms2799
- I. Thiele, N. Swainston, R.M.T. Fleming, A. Hoppe, S. Sahoo, M.K. Aurich, H. Haraldsdottir, M.L. Mo, O. Rolfsson, M.D. Stobbe, S.G. Thorleifsson, R. Agren, C. Bölling, S. Bordel, A.K. Chavali, P. Dobson, W.B. Dunn, L. Endler, D. Hala, M. Hucka, D. Hull, D. Jameson, N. Jamshidi, J.J. Jonsson, N. Juty, S. Keating, I. Nookaew, N. le Novère, N. Malys, A. Mazein, J.A. Papin, N.D. Price, Sr. Selkov E, M.I. Sigurdsson, E. Simeonidis, N. Sonnenschein, K. Smallbone, A. Sorokin, J.H. van Beek, D. Weichart, I. Goryanin, J. Nielsen, H.V. Westerhoff, D.B. Kell, P. Mendes & B.Ø. Palsson (2013). A community-driven global reconstruction of human metabolism. Nature Biotechnology, 31 (5), 419-25. doi: 10.1038/nbt.2488
- M.J. Quinton-Tulloch, F.J. Bruggeman, J.L. Snoep & H.V. Westerhoff (2013). Trade-off of dynamic fragility but not of robustness in metabolic pathways in silico. The FEBS Journal, 280 (1), 160-173. doi: 10.1111/febs.12057
- M. Verma, E.G. Karimiani, R.J. Byers, S. Rehman, H.V. Westerhoff & P.J. Day (2013). 555 mediated BCR.ABL protein regulation in chronic myeloid leukaemia vis-a-vis therapeutic strategies. Integrative Biology, 5 (3), 543-554. doi: 10.1039/c3ib20230e[go to publisher's site]
- A. Kolodkin, E. Simeonidis & H.V. Westerhoff (2013). Computing life: Add logos to biology and bios to physics. Progress in Biophysics & Molecular Biology, 111 (2-3), 69-74. doi: 10.1016/j.pbiomolbio.2012.10.003
- A. Kolodkin, E. Simeonidis & H.V. Westerhoff (2013). Computing life: add logos to biology and bios to physics. Progress in Biophysics & Molecular Biology, 111 (2-3), 69-74. doi: 10.1016/j.pbiomolbio.2012.10.003
- S. Geenen, J.W.T. Yates, J.G. Kenna, F.Y. Bois, I.D. Wilson & H.V. Westerhoff (2013). Multiscale modelling approach combining a kinetic model of glutathione metabolism with PBPK models of paracetamol and the potential glutathione-depletion biomarkers ophthalmic acid and 5-oxoproline in humans and rats. Integrative Biology, 5 (6), 877-888. doi: 10.1039/c3ib20245c[go to publisher's site]
- K. Smallbone, H.L. Messiha, K.M. Carroll, C.L. Winder, N. Malys, W.B. Dunn, E. Murabito, N. Swainston, J.O. Dada, F. Khan, P. Pir, E. Simeonidis, I. Spasić, J. Wishart, D. Weichart, N.W. Hayes, D. Jameson, D.S. Broomhead, S.G. Oliver, S.J. Gaskell, J.E.G. McCarthy, N.W. Paton, H.V. Westerhoff, D.B. Kell & P. Mendes (2013). A model of yeast glycolysis based on a consistent kinetic characterisation of all its enzymes. FEBS Letters, 587 (17), 2832-2841. doi: 10.1016/j.febslet.2013.06.043
- F.I. Mensonides, B.M. Bakker, F. Cremazy, H.L. Messiha, P. Mendes, F.C. Boogerd & H.V. Westerhoff (2013). A new regulatory principle for in vivo biochemistry: pleiotropic low affinity regulation by the adenine nucleotides--illustrated for the glycolytic enzymes of Saccharomyces cerevisiae. FEBS Letters, 587 (17), 2860-2867. doi: 10.1016/j.febslet.2013.07.013
- T. Kouril, D. Esser, J. Kort, H.V. Westerhoff, B. Siebers & J.L. Snoep (2013). Intermediate instability at high temperature leads to low pathway efficiency for an in vitro reconstituted system of gluconeogenesis in Sulfolobus solfataricus. The FEBS Journal, 280 (18), 4666-4680. doi: 10.1111/febs.12438
- A. Feldman-Salit, S. Hering, H.L. Messiha, N. Veith, V. Cojocaru, A. Sieg, H.V. Westerhoff, B. Kreikemeyer, R.C. Wade & T. Fiedler (2013). Regulation of the activity of lactate dehydrogenases from four lactic acid bacteria. The Journal of Biological Chemistry, 288 (29), 21295-21306. doi: 10.1074/jbc.M113.458265
- S. Geenen, F.B. du Preez, J.L. Snoep, A.J. Foster, S. Sarda, J.G. Kenna, I.D. Wilson & H.V. Westerhoff (2013). Glutathione metabolism modeling: a mechanism for liver drug-robustness and a new biomarker strategy. Biochimica et Biophysica Acta, 1830 (10), 4943-59. doi: 10.1016/j.bbagen.2013.04.014
2012
- R. García-Contreras, P. Vos, H.V. Westerhoff & F.C. Boogerd (2012). Why in vivo may not equal in vitro - new effectors revealed by measurement of enzymatic activities under the same in vivo-like assay conditions. The FEBS Journal, 279 (22), 4145-4159. doi: 10.1111/febs.12007
- J. Jozefczuk, K. Kashofer, R. Ummanni, F. Henjes, S. Rehman, S. Geenen, W. Wruck, C. Regenbrecht, A. Daskalaki, C. Wierling, P. Turano, I. Bertini, U. Korf, K. Zatloukal, H.V. Westerhoff, H. Lehrach & J. Adjaye (2012). A systems biology approach to deciphering the etiology of steatosis employing patient-derived dermal fibroblasts and iPS cells. Frontiers in Physiology, 3, 339. doi: 10.3389/fphys.2012.00339[go to publisher's site]
- S. Rehman, P.J.R. Day, A. Bayat & H.V. Westerhoff (2012). Understanding Dupuytren's disease using systems biology: a move away from reductionism. Frontiers in Physiology, 3, 316. doi: 10.3389/fphys.2012.00316[go to publisher's site]
- M. Adamczyk & H.V. Westerhoff (2012). Engineering of self-sustaining systems: substituting the yeast glucose transporter plus hexokinase for the Lactococcus lactis phosphotransferase system in a Lactococcus lactis network in silico. Biotechnology Journal, 7 (7), 877-883. doi: 10.1002/biot.201100314
- S. Geenen, P.N. Taylor, J.L. Snoep, I.D. Wilson, J.G. Kenna & H.V. Westerhoff (2012). Systems biology tools for toxicology. Archives of toxicology = Archiv für Toxikologie, 86 (8), 1251-1271. doi: 10.1007/s00204-012-0857-8[go to publisher's site]
- A. Kolodkin, E. Simeonidis, R. Balling & H.V. Westerhoff (2012). Understanding complexity in neurodegenerative diseases: in silico reconstruction of emergence. Frontiers in Physiology, 3, 291. doi: 10.3389/fphys.2012.00291[go to publisher's site]
- K. van Eunen, J.A.L. Kiewiet, H.V. Westerhoff & B.M. Bakker (2012). Testing biochemistry revisited: how in vivo metabolism can be understood from in vitro enzyme kinetics. PLoS Computational Biology, 8 (4), e1002483. doi: 10.1371/journal.pcbi.1002483[go to publisher's site]
- M.J. Quinton-Tulloch, F.J. Bruggeman, J.L. Snoep & H.V. Westerhoff (2012). Trade-off of dynamic fragility but not of robustness in metabolic pathways in silico. The FEBS Journal, 280 (1), 160-173. doi: 10.1111/febs.12057
2011
- S. Geenen, F.B. du Preez, M. Reed, H.F. Nijhout, J.G. Kenna, I.D. Wilson, H.V. Westerhoff & J.L. Snoep (2011). A mathematical modelling approach to assessing the reliability of biomarkers of glutathione metabolism. European Journal of Pharmaceutical Sciences, 46 (4), 233-243. doi: 10.1016/j.ejps.2011.08.017
- C.A. Sellick, A.S. Croxford, A.R. Maqsood, G. Stephens, H.V. Westerhoff, R. Goodacre & A.J. Dickson (2011). Metabolite profiling of recombinant CHO cells: designing tailored feeding regimes that enhance recombinant antibody production. Biotechnology and Bioengineering, 108 (12), 3025-3031. doi: 10.1002/bit.23269
2010
- K. van Eunen, J. Bouwman, P. Daran-Lapujade, J. Postmus, A.B. Canelas, F.I.C. Mensonides, R. Orij, I. Tuzun, J. van den Brink, G.J. Smits, W.M. van Gulik, S. Brul, J.J. Heijnen, J.H. de Winde, M.J. Teixeira De Mattos, C. Kettner, J. Nielsen, H.V. Westerhoff & B.M. Bakker (2010). Measuring enzyme activities under standardized in vivo-like conditions for systems biology. The FEBS Journal, 277 (3), 749-760. doi: 10.1111/j.1742-4658.2009.07524.x
2009
- H.M. Härdin, A. Zagaris, K. Krab & H.V. Westerhoff (2009). Simplified yet highly accurate enzyme kinetics for cases of low substrate concentrations. The FEBS Journal, 276 (19), 5491-5506.
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