contact

dr. R. (Renée) van Amerongen


  • Faculty of Science
    SILS
  • POSTBUS  94215
    1090 GE  Amsterdam
    Room number: C2.261 (leveringen op lab A2.24 of bij afwezigheid op C2.267)
  • R.vanAmerongen@uva.nl
    T:  0205255682

Work experience

2013 - : MacGillavry fellow and tenure track assistant professor at the University of Amsterdam

2011 - 2013: senior postdoc with prof.dr. Daniel Peeper at the Netherlands Cancer Institute

2008 - 2011: postdoc with prof.dr. Roel Nusse at Stanford University, USA

1999 - 2005: PhD thesis research with prof.dr. Anton Berns at the Netherlands Cancer Institute 

 

Education

2005 PhD (cum laude) from the Universiteit van Amsterdam

1999 MSc (cum laude) from the  Vrije Universiteit Amsterdam

 

Honors and Awards

2014 NWO VIDI grant

2013 NWO Aspasia (declined)

2013 KWF persoonsgebonden financiering

2013  MacGillavry fellowship

2007 4-year KWF fellowship for fundamental cancer research 

2007 longterm EMBO fellowship 

Wnt-responsive stem cells (green) contribute to alveoli formation in the mammary gland during multiple rounds of pregnancy, lactation and involution

Development of a multicellular organism requires tight control of cell proliferation, differentiation and polarized cell movements to ensure the correct assembly of cells into complex tissues. The same molecular mechanisms that normally guide these biological processes in the developing embryo, maintain tissue homeostasis in the adult. When disrupted, they are the underlying cause of degenerative diseases, tumor formation and, ultimately, aging.

My ultimate goal is to get a better understanding of tumor initiation and progression by translating principles of developmental and stem cell biology to cancer research and regenerative medicine. In this, I combine my background in molecular genetics and oncology with my recent experience in developmental biology and stem cell research.

 

 

 

My team is particularly interested in the behavior and control of Wnt-responsive stem cells. Using a combination of in vitro and in vivo approaches, we study how the diverse array of Wnt proteins and cell surface receptors can elicit such different, yet specific, cellular responses in a complex, intact organism.

 

For more information, visit our lab website. 

2014

  • R. van Amerongen (2014). Bipotent mammary stem cells: now in amazing 3D. Breast Cancer Research, 2014 (16):480. doi: 10.1186/s13058-014-0480-0
  • Y. Rinkevich, D.T. Montoro, H. Contreras-Trujillo, O. Harari-Steinberg, A.M. Newman, J.M. Tsai, X. Lim, R. van Amerongen, A. Bowman, M. Januszyk, O. Pleniceanu, R. Nusse, M.T. Longaker, I.L. Weissman & B. Dekel (2014). In vivo clonal analysis reveals lineage-restricted progenitor characteristics in mammalian kidney development, maintenance, and regeneration. Cell Reports, 7 (4), 1270-83. doi: 10.1016/j.celrep.2014.04.018
  • J. Green, R. Nusse & R. van Amerongen (2014). The role of Ryk and Ror receptor tyrosine kinases in Wnt signal transduction. Cold Spring Harbor Perspectives in Biology, 6 (2), 009175. doi: 10.1101/cshperspect.a009175
  • K. Kemper, P.L. de Goeje, D.S. Peeper & R. van Amerongen (2014). Phenotype switching: tumor cell plasticity as a resistance mechanism and target for therapy. Cancer Research, 74 (21), 5937-41. doi: 10.1158/0008-5472.CAN-14-1174
  • M. Shehata, R. van Amerongen, A.L. Zeeman, R.R. Giraddi & J. Stingl (2014). The influence of tamoxifen on normal mouse mammary gland homeostasis. Breast Cancer Research, 16 (4), 411. doi: 10.1186/s13058-014-0411-0[go to publisher's site]

2013

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