dhr. dr. F.M. (Frans) Klis

  • Faculteit der Natuurwetenschappen, Wiskunde en Informatica
  • Bezoekadres:
    Science Park A
    Science Park 904  Amsterdam
    Kamernummer: C3.269
  • Postadres:
    Postbus  94232
    1090 GE  Amsterdam
  • F.M.Klis@uva.nl
    T:  0205257834
    T:  0205256970

Research interests

Candida albicans is an opportunistic pathogenic fungus that inhabits the mucosal layers of the human body but can cause fatal systemic infections when the immune system deteriorates. Its walls are covered by a dense coat of 20-30 different covalently linked proteins, which interact with host cells and help to counteract various forms of environmental stress. In our studies we focus on: (1) characterization and regulation of the wall proteome under infection-related stress conditions; (2) functions of individual wall proteins; (3) identification of vaccine antigens based on wall proteins, and (4) identification of diagnostic markers based on secretome proteins.

Keywords: fungal wall, Candida albicans , iron acquisition, wall proteome, secretome, wall stress responses, stress physiology,  vaccine development, diagnostic markers


For a general overview visit: http://scholar.google.nl/citations?user=g9iyZT8AAAAJ&hl=nl

Recent reviews:

  1. Klis FM, Boorsma A, De Groot PW (2006). Cell wall construction in Saccharomyces cerevisiae . Yeast 23:185-202.
  2. Klis FM, Sosinska GJ, de Groot PW, Brul S (2009). Covalently linked cell wall proteins of Candida albicans and their role in fitness and virulence. FEMS Yeast Res 9:1013-1028
  3. Yin QY, deGroot PW, de Koster CG, Klis FM (2008). Mass spectrometry-based proteomics of fungal wall glycoproteins. Trends in Microbiol 16: 20-26.
  4. Klis  FM, de Koster CG, Brul S (2011) A mass spectrometric view of  the fungal wall proteome . Future Microbiology 6: 9 41-951
  5. Heilmann CJ, Sorgo AG, Klis FM (2012) News from the fungal front: wall proteome dynamics and host-pathogen interplay. PLoS Pathog 8(12): e1003050


Editorial Boards

Eukaryotic Cell
FEMS Yeast Research

Website of my department

Head: Prof. Dr. Stanley Brul








  • M. Gonzalez, P.W.J. de Groot, F.M. Klis & P.N. Lipke (2009). Glycoconjugate structure and function in fungal cell walls. In A.P. Moran, O. Holst, P.J. Brennan & M. von Itzstein (Eds.), Microbial glycobiology: structures, relevance and applications (pp. 169-183). Amsterdam: Academic Press.
  • J.R. Wortman, J.M. Gilsenan, V. Joardar, J. Deegan, J. Clutterbuck, M.R. Andersen, D. Archer, M. Bencina, G. Braus, P. Coutinho, H. von Döhren, J. Doonan, A.J.M. Driessen, P. Durek, E. Espeso, E. Fekete, M. Flipphi, C.G. Estrada, S. Geysens, G. Goldman, P.W.J. de Groot, K. Hansen, S.D. Harris, T. Heinekamp, K. Helmstaedt, B. Henrissat, G. Hofmann, T. Homan, T. Horio, H. Horiuchi, S. James, M. Jones, L. Karaffa, Z. Karányi, M. Kato, N. Keller, D.E. Kelly, J.A.K.W. Kiel, J.M. Kim, I.J. van der Klei, F.M. Klis, A. Kovalchuk, N. Kraševec, C.P. Kubicek, B. Liu, A. MacCabe, V. Meyer, P. Mirabito, M. Miskei, M. Mos, J. Mullins, D.R. Nelson, J. Nielsen, B.R. Oakley, S.A. Osmani, T. Pakula, A. Paszewski, I. Paulsen, S. Pilsyk, I. Pócsi, P.J. Punt, A.F.J. Ram, Q. Ren, X. Robellet, G. Robson, B. Seiboth, P. van Solingen, T. Specht, J. Sun, N. Taheri-Talesh, N. Takeshita, D. Ussery, P.A. vanKuyk, H. Visser, P.J.I. van de Vondervoort, R.P. de Vries, J. Walton, X. Xiang, Y. Xiong, A.P. Zeng, B.W. Brandt, M.J. Cornell, C.A.M.J.J. van den Hondel, J. Visser, S.G. Oliver & G. Turner (2009). The 2008 update of the Aspergillus nidulans genome annotation: A community effort. Fungal Genetics and Biology, 46 (1), S2-S13. doi: 10.1016/j.fgb.2008.12.003
  • J.M. ten Cate, F.M. Klis, T. Pereira-Cenci, W. Crielaard & P.W.J. de Groot (2009). Molecular and cellular mechanisms that lead to Candida biofilm formation. Journal of Dental Research, 88 (2), 105-115. doi: 10.1177/0022034508329273
  • E. Moreno-Ruiz, G. Ortu, P.W.J. de Groot, F. Cottier, C. Loussert, M.C. Prévost, C. de Koster, F.M. Klis, S. Goyard & C. d'Enfert (2009). The GPI-modified proteins Pga59 and Pga62 of Candida albicans are required for cell wall integrity. Microbiology - SGM, 155 (6), 2004-2020. doi: 10.1099/mic.0.028902-0
  • G. Butler, M.D. Rasmussen, M.F. Lin, M.A.S. Santos, S. Sakthikumar, C.A. Munro, E. Rheinbay, M. Grabherr, A. Forche, J.L. Reedy, I. Agrafioti, M.B. Arnaud, S. Bates, A.J.P. Brown, S. Brunke, M.C. Costanzo, D.A. Fitzpatrick, P.W.J. de Groot, D. Harris, L.L. Hoyer, B. Hube, F.M. Klis, C. Kodira, N. Lennard, M.E. Logue, R. Martin, A.M. Neiman, E. Nikolaou, M.A. Quail, J. Quinn, M.C. Santos, F.F. Schmitzberger, G. Sherlock, P. Shah, K.A.T. Silverstein, M.S. Skrzypek, D. Soll, R. Staggs, I. Stansfield, M.P.H. Stumpf, P.E. Sudbery, T. Srikantha, Q. Zeng, J. Berman, M. Berriman, J. Heitman, N.A.R. Gow, M.C. Lorenz, B.W. Birren, M. Kellis & C.A. Cuomo (2009). Evolution of pathogenicity and sexual reproduction in eight Candida genomes. Nature, 459 (7247), 657-662. doi: 10.1038/nature08064
  • P.W.J. de Groot, B.W. Brandt, H. Horiuchi, A.F.J. Ram, C.G. de Koster & F.M. Klis (2009). Comprehensive genomic analysis of cell wall genes in Aspergillus nidulans. Fungal Genetics and Biology, 46 (1), S72-S81. doi: 10.1016/j.fgb.2008.07.022
  • F.M. Klis, G.J. Sosinska, P.W.J. de Groot & S. Brul (2009). Covalently linked cell wall proteins of Candida albicans and their role in fitness and virulence. FEMS Yeast Research, 9 (7), 1013-1028. doi: 10.1111/j.1567-1364.2009.00541.x



  • I. Klei, M. Veenhuis, S. Brul, F.M. Klis, P.W.J. de Groot, W.H. Müller, K.G.A. van Driel & T. Boekhout (2011). Cytology, Cell Walls and septa: A Summary of Yeast Cell Biology from a Phylogenetic Perspective. In C..P. Kurtzman, J..W. Fell & T. Boekhout (Eds.), The Yeasts, a Taxonomic Study, Volume 1 (pp. 111-128). London: Elsevier.
  • P.W.J. de Groot, S. Brul & F.M. Klis (2011). Exploring the fungal wall glycoproteome. (vol. 4: Essential reviews in experimental biology). In SA Brooks, PM Rudd & BJ Appelmelk (Eds.), Glycosylation in Diverse Cell Systems: Challenges and New Frontiers in Experimental Glycobiology (pp. 118-138). London, UK: The Society for Experimental Biology.
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