mw. dr. L.M. (Lucia) Talamini

  • Faculteit der Maatschappij- en Gedragswetenschappen
    Programmagroep: Brain & Cognition
  • Weesperplein  4
    1018 XA  Amsterdam
    T:  0205256742
    T:  0205256840

Biographical Sketch

L.M. Talamini obtained a masters in Biology in 1991, at the University of Leiden, with specializations in Medical Biology and Neurobiology. Over the following 3 years she worked on growth factor-induced plasticity, at the Institute of Neurobiology in Rome (with L.Aloe and R. Levi-Montalcini) and on NMDA receptor plasticity at the dept. of Experimental Animal Physiology (with W. Kamphuis and F. Lopez Da Silva). She obtained her PhD in 2000, at the University of Groningen, where she developed an animal model of schizophrenia (with J. Korf). In 1999 she joined the Psychonomics program of the University of Amsterdam, to developed neural network models of memory and schizophrenia, broadening her perspective on human cognition. She left the department in 2002, towork as agroup leaderand cognition specialist in schizophrenia drug discovery at Johnson & Johnson Pharmaceutical Research and Development. In 2004 she returned to her present affliation. Talamini has published widely in the fields of memory, schizophrenia and neural network modeling.

Research interests

Talamini's current research interests concern the relation between brain and cognition, especially with regard to memory, the role of sleep in memory, and cognitive dysfunctions in schizophrenia. She adopts an integrated approach, involving experimentation (in humans and animals) and neural network modelling, to bridge the gap between brain and behaviour. Examples of her work are the animal (MAM) model of schizophrenia, based on prenatal interference with mediotemporal lobe development, and several neural network models involving mediotemporal lobe structures. The latter models address different features of memory, including recall, recognition and interference, but also sequence learning and novelty detection. They show how these functions emerge from processes at the neural level, involving for instance neurotransmitter interactions, brain oscillatory mechanisms and interplay between mediotemporal lobe subregions. These models can be 'lesioned' to study effects on behavior. It was, for instance, shown how a schizophrenia-like neuropathology leads to memory and context processing deficits that parallel observations in patients. The models often lead to original predictions that can be tested experimentaly, leading to increased understanding of cognitive (dys)function.

Selected publications

Roy Cox, Winni F. Hofman & Lucia M. Talamini (2012). Involvement of spindles in memory consolidation is slow wave sleep-specific. Learning and Memory. In press.

Lucia M. Talamini and Eva Gorree (2012). Ageing memories: differential decay of episodic memory components. Learning and Memory. In press.

Laura F. Bringmann, Winni F. Hofman & Lucia M. Talamini (2011). The effect of emotional stimuli on sleep architecture in healthy subjects. Sleep-Wake Research in the Netherlands, 22, 40-43.

Talamini, L. M., Sweegers, C. C., & Hofman, W. F. (2010). Daytime napping and emotional and declarative memory. Journal of Sleep Research, 19(Suppl. 2), 120.

Hofman, W. F., Cox, R., & Talamini, L. M. (2010). Effects of an emotional film on sleep EEG: relation with emotional attenuation over sleep. Journal of Sleep Research, 19(Suppl. 2), 134.

Lucia M. Talamini, Lieuwe de Haan MD, , Dorien H. Nieman, Don H. Linszen, Martijn Meeter. (2010) R educed context effects on retrieval in first-episode schizophrenia. PloS ONE, 5(4):e10356 .

Talamini L.M. and Meeter M. (2009) Dominance of objects over context in a mediotemporal lobe model of schizophrenia. PloS ONE, 4(8):e6505.

Atsuko Takashima, Ingrid Nieuwenhuis, Ole Jensen, Lucia Talamini, Mark Rijpkema, Guillen Fernandez. (2009) Shift from hippocampal to neocortical centered retrieval network with consolidation. J. Neurosci., 29(32):10087-93.

Lucia M. Talamini, Ingrid L.C. Nieuwenhuis, Atsuko Takashima and Ole Jensen. (2008) Sleep directly following learning benefits consolidation of spatial associative memory. Learning and Memory. 15(4):233-7.

Meeter M., Riedel W., Schmitt, Talamini L.M. (2006) Effects of 5-HT on memory and the hippocampus: model and data. Neuropsychopharmacology 31(4):712-20.

Lisman JE, Talamini LM, Raffone A. (2005) Recall of memory sequences by interaction of the dentate and CA3: A revised model of the phase precession. Neural Netw. 18: 1191-1201.

Talamini L.M., Meeter M., Elvevåg B., Murre J.M.J., & Goldberg T.E. (2005) Reduced parahippocampal connectivity produces schizophrenia-like memory deficits in simulated neural circuits. Arch Gen Psychiatry. 62(5):485-93.

Meeter M., Murre J.M. J. and Talamini L.M. (2004) Mode shifting between storage and recall based on novelty detection in oscillating hippocampal circuits. Hippocampus, 14, 722-41.

Talamini L.M., Meeter M. and Murre J.M.J. (2003) Combating fuzziness with computational modeling. Behavioral and Brain Sciences, 26, 107-108

Meeter M., Murre J.M.. and Talamini L.M. (2002) A computational approach to memory deficits in schizophrenia. Neurocomputing, 44, 929-936.

Fiore M, Korf J, Antonelli A, Talamini L, Aloe L. ( 2002) Long-lasting effects of prenatal MAM treatment on water maze performance in rats: Associations with altered brain development and neurotrophin levels. Neurotoxicol Teratol., 24, 179-191.

Talamini L.M., Ellenbroek B., Koch T. and J. Korf. (2000) Impaired sensory gating and attention in rats with developmental abnormalities of the mesocortex. Ann. New York Acad. Sci. 911, 486-495.

Fiore M., Korf J., Angelucci F., Talamini L.M. and Aloe L. (2000) Prenatal exposure to methylazoxymethanol acetate in the rat alters neurotrophin levels and behavior: considerations for neurodevelopmental diseases. Physiol. Behav. 71, 57-67.

Talamini L.M., Koch T., Luiten P.G.M., Koolhaas J.M. and Korf J. (1999) Interruptions of early cortical development affect limbic association areas and social behaviour in rats; possible relevance for neurodevelopmental disorders. Brain Research 847, 105-120.

Fiore M., Talamini L.M., Angelucci F., KochT., AloeL.and KorfJ. (1999) Prenatal methylazoxymethanol acetate alters behaviour and brain NGF levels in young rats: a possible correlation with the development of schizophrenia-like deficits.   Neuropharmacology 38, 857-869.

Talamini L.M. Koch T and Korf J. (1998) Methylazoxymethanol acetate-induced abnormalities in the entorhinal cortex of the rat; parallels with morphological findings in schizophrenia. Brain Research 789, 293-306.

Books and book contributions

Talamini L.M. and van der Werf Y. Slaap en geheugen. In: Handboek Slaap (eds. J. Verbraecken, B. Buyse, H. Hamburger, V. van Kasteel en R. van Steenwijk). Uitgeverij ACCO. In preparation.  
Talamini L.M. Slapen en Breinleren. In: Breinboek voor opleiders (eds. N. Lazeron en R. van Dinteren). Bohn Stafleu van Loghum te Houten, 2010.
Talamini L.M. Louwerens J.W and Korf J. PET versus post mortem studies in schizophrenia research: significance for the pathogenesis and pharmacotherapy.   In: Advances in the neurobiology of schizophrenia (eds. J.A. den Boer, H.G.M. Westenberg and H.M. van Praag). John Wiley & Sons, Ltd, 1995. pp. 157-188.




  • L.M. Talamini, L.F. Bringmann, M. de Boer & W.F. Hofman (2013). Sleeping worries away or worrying away sleep? Physiological evidence on sleep-emotion interactions. PLoS One, 8 (5), e62480. doi: 10.1371/journal.pone.0062480
  • M. de Boer, M.J. Nijdam, W.F. Hofman, M. Olff & L.M. Talamini (2013). Effects of emotional experience on sleep depend on circadian phase. In European Conference of Traumatic stress Vol. 4. European Journal of Psychotraumatology. Bologna.
  • L.M. Talamini, R. Cox, C.C.G. Sweegers & W.F. Hofman (2013). Effects of emotional experience on sleep deped on circadian phase. In Society for Neuroscience (SFN). San Diego, USA.
  • L.M. Talamini, R. Cox, C.C.G. Sweegers & W.F. Hofman (2013). Effects of emotional experience on sleep depend on circadian phase. In European Brain and Behavior Society (EBBS). Munich, Germany.
  • M.J. Nijdam, M. de Boer, W.F. Hofman, L.M. Talamini & M. Olff (2013). The role of sleep in emotional memory processing in PTSD patients. In International Society for Trauma and Stress Studies (ISTSS). Philadelphia, USA.






  • L.F. Bringmann, W.F. Hofman & L.M. Talamini (2011). The effect of emotional stimuli on sleep architecture in healthy subjects. Sleep-Wake Research in the Netherlands, 22, 40-43.
  • R. Cox, W.F. Hofman & L.M. Talamini (2011). Retention-dependent increases in sleep spindle density: a specific SWS phenomenon. Sleep-Wake Research in the Netherlands, 22, 48-51.


  • L.M. Talamini (2010). Slapen en Breinleren. In Breinboek voor opleiders. Houten: Bohn Stafleu van Loghum.

Wetenschappelijke positie

  • L.M. Talamini (period: 2010 till 2010). Collaboration with M. Meeter, Hippocampal modeling. - Cognitive Psychology, VU.
  • L.M. Talamini (period: 2010 till 2010). Collaboration with W. Hofman and J. Murre (UvA), O. Jensen, G. Fernandez, A. Takashima and I. Nieuwenhuis (F.C Donders centre for Cognitive Neuroimaging, Nijmegen) and B. McNaugton (Depts. of Psychology and Physiology, Univ. of Arizona). Memory consolidation and sleep. - UvA, F.C Donders centre for Cognitive Neuroimaging, Nijmegen,Depts. of Psychology and Physiology, Univ. of Arizona.

Wetenschappelijke positie

  • R. Cox & L.M. Talamini (2014). Neural mechanisms linking sleep and memory.


  • L.M. Talamini (2014, September 16). ASRS. Tallinn, Estonia, Chair and opening lecture: symposium on Learning, Memory and Cognition.
  • L.M. Talamini (). Interregional communication in sleeping cortical networks. Salzburg, Lecture at 2nd Winter-Symposium "Sleep, Cognition and Consciousness.
  • L.M. Talamini (2014, March 18). Memory processing during sleep; from brain to behaviour. Tübingen, Plenary lecture, SFB Meeting on Sleep and Plasticity.
  • L.M. Talamini (2014, April 2). Brain Slicing Event. Amsterdam, Yearly brain dissection workshop, held during spring in Amsterdam.
  • L.M. Talamini (2014, October 8). Hersenontwikkeling in de klas. Den Bosch, Lerarencongres.


  • L.M. Talamini (Ed.). (2010) The Open Behavioral Science Journal.
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