Chen, T., Brul, S., & Hugenholtz, J. (2023). Exploring the potential of Bacillus subtilis as cell factory for food ingredients and special chemicals. Microbial Cell Factories, 22, Article 200. https://doi.org/10.1186/s12934-023-02208-w[details]
Benito-Vaquerizo, S., Nouse, N., Schaap, P. J., Hugenholtz, J., Brul, S., López-Contreras, A. M., Martins Dos Santos, V. A. P., & Suarez-Diez, M. (2022). Model-driven approach for the production of butyrate from CO2/H2 by a novel co-culture of C. autoethanogenum and C. beijerinckii. Frontiers in Microbiology, 13, Article 1064013. https://doi.org/10.3389/fmicb.2022.1064013[details]
Dijkstra, A. R., Starrenburg, M. J. C., Todt, T., van Hijum, S. A. F. T., Hugenholtz, J., & Bron, P. A. (2018). Transcriptome Analysis of a Spray Drying-Resistant Subpopulation Reveals a Zinc-Dependent Mechanism for Robustness in L. lactis SK11. Frontiers in Microbiology, 9, Article 2418. https://doi.org/10.3389/fmicb.2018.02418[details]
Dijkstra, A. R., Alkema, W., Starrenburg, M. J. C., Hugenholtz, J., van Hijum, S. A. F. T., & Bron, P. A. (2016). Strain-Dependent Transcriptome Signatures for Robustness in Lactococcus lactis. PLoS ONE, 11(12), Article e0167944. https://doi.org/10.1371/journal.pone.0167944[details]
Levering, J., Fiedler, T., Sieg, A., van Grinsven, K. W. A., Hering, S., Veith, N., Olivier, B. G., Klett, L., Hugenholtz, J., Teusink, B., Kreikemeyer, B., & Kummer, U. (2016). Genome-scale reconstruction of the Streptococcus pyogenes M49 metabolic network reveals growth requirements and indicates potential drug targets. Journal of Biotechnology, 232, 25-37. Advance online publication. https://doi.org/10.1016/j.jbiotec.2016.01.035[details]
Tyler, C. A., Kopit, L., Doyle, C., Yu, A. O., Hugenholtz, J., & Marco, M. L. (2016). Polyol production during heterofermentative growth of the plant isolate Lactobacillus florum 2F. Journal of Applied Microbiology, 120(5), 1336-1345. Advance online publication. https://doi.org/10.1111/jam.13108[details]
2015
Veith, N., Solheim, M., van Grinsven, K. W. A., Olivier, B. G., Levering, J., Grosseholz, R., Hugenholtz, J., Holo, H., Nes, I., Teusink, B., & Kummer, U. (2015). Using a genome-scale metabolic model of Enterococcus faecalis V583 to assess amino acid uptake and its impact on central metabolism. Applied and Environmental Microbiology, 81(5), 1622-1633. Advance online publication. https://doi.org/10.1128/AEM.03279-14[details]
Dijkstra, A. R., Alkema, W., Starrenburg, M. J. C., Hugenholtz, J., van Hijum, S. A. F. T., & Bron, P. A. (2014). Fermentation-induced variation in heat and oxidative stress phenotypes of Lactococcus lactis MG1363 reveals transcriptome signatures for robustness. Microbial Cell Factories, 13, 148. https://doi.org/10.1186/s12934-014-0148-6[details]
Dijkstra, A. R., Setyawati, M. C., Bayjanov, J. R., Alkema, W., van Hijum, S. A. F. T., Bron, P. A., & Hugenholtz, J. (2014). Diversity in robustness of Lactococcus lactis strains during heat stress, oxidative stress, and spray drying stress. Applied and Environmental Microbiology, 80(2), 603-611. Advance online publication. https://doi.org/10.1128/AEM.03434-13[details]
van de Bunt, B., Bron, P. A., Sijtsma, L., de Vos, W. M., & Hugenholtz, J. (2014). Use of non-growing Lactococcus lactis cell suspensions for production of volatile metabolites with direct relevance for flavour formation during dairy fermentations. Microbial Cell Factories, 13, Article 176. https://doi.org/10.1186/s12934-014-0176-2[details]
Levering, J., Musters, M. W., Bekker, M., Bellomo, D., Fiedler, T., de Vos, W. M., Hugenholtz, J., Kreikemeyer, B., Kummer, U., & Teusink, B. (2012). Role of phosphate in the central metabolism of two lactic acid bacteria - a comparative systems biology approach. The FEBS Journal, 279(7), 1274-1290. https://doi.org/10.1111/j.1742-4658.2012.08523.x[details]
2011
Fiedler, T., Bekker, M., Jonsson, M., Mehmeti, I., Pritzschke, A., Siemens, N., Nes, I., Hugenholtz, J., & Kreikemeyer, B. (2011). Characterization of three lactic acid bacteria and their isogenic ldh deletion mutants shows optimization for Y(ATP) (cell mass produced per mole of ATP) at their physiological pHs. Applied and Environmental Microbiology, 77(2), 612-617. https://doi.org/10.1128/AEM.01838-10[details]
Santos, F., Spinler, J. K., Saulnier, D. M. A., Molenaar, D., Teusink, B., de Vos, W. M., Versalovic, J., & Hugenholtz, J. (2011). Functional identification in Lactobacillus reuteri of a PocR-like transcription factor regulating glycerol utilization and vitamin B12 synthesis. Microbial Cell Factories, 10, Article 55. https://doi.org/10.1186/1475-2859-10-55, https://doi.org/10.1186/1475-2859-10-55[details]
Goffin, P., van de Bunt, B., Giovane, M., Leveau, J. H. J., Höppener-Ogawa, S., Teusink, B., & Hugenholtz, J. (2010). Understanding the physiology of Lactobacillus plantarum at zero growth. Molecular Systems Biology, 6, 413. https://doi.org/10.1038/msb.2010.67[details]
LeBlanc, J. G., Sybesma, W., Starrenburg, M., Sesma, F., de Vos, W. M., Savoy de Giori, G., & Hugenholtz, J. (2010). Supplementation with engineered Lactococcus lactis improves the folate status in deficient rats. Nutrition, 26(7-8), 835-841. https://doi.org/10.1016/j.nut.2009.06.023[details]
LeBlanc, J. G., van Sinderen, D., Hugenholtz, J., Piard, J. C., Sesma, F., & Savoy de Giori, G. (2010). Risk assessment of genetically modified lactic acid bacteria using the concept of substantial equivalence. Current Microbiology, 61(6), 590-595. https://doi.org/10.1007/s00284-010-9657-7[details]
Maischberger, T., Mierau, I., Peterbauer, C. K., Hugenholtz, J., & Haltrich, D. (2010). High-level expression of Lactobacillus beta-galactosidases in Lactococcus lactis using the food-grade, nisin-controlled expression system NICE. Journal of Agricultural and Food Chemistry, 58(4), 2279-2287. https://doi.org/10.1021/jf902895g[details]
2008
Bekaert, S., Storozhenko, S., Mehrshahi, P., Bennett, M. J., Lambert, W., Gregory III, J. F., Schubert, K., Hugenholtz, J., van der Straeten, D., & Hanson, A. D. (2008). Folate biofortification in food plants. Trends in Plant Science, 13(1), 28-35. https://doi.org/10.1016/j.tplants.2007.11.001[details]
Santos, F., Vera, J. L., van der Heijden, R., Valdez, G., de Vos, W. M., Sesma, F., & Hugenholtz, J. (2008). The complete coenzyme B12 biosynthesis gene cluster of Lactobacillus reuteri CRL1098. Microbiology - SGM, 154(1), 81-93. https://doi.org/10.1099/mic.0.2007/011569-0[details]
Santos, F., Wegkamp, A., de Vos, W. M., Smid, E. J., & Hugenholtz, J. (2008). High-level folate production in fermented foods by the B12 producer Lactobacillus reuteri JCM1112. Applied and Environmental Microbiology, 74(10), 3291-3294. https://doi.org/10.1128/AEM.02719-07[details]
Sieuwerts, S., de Bok, F. A. M., Hugenholtz, J., & van Hylckama Vlieg, J. E. T. (2008). Unraveling microbial interactions in food fermentations: From classical to genomics approaches. Applied and Environmental Microbiology, 74(16), 4997-5007. https://doi.org/10.1128/AEM.00113-08[details]
2008
Wegkamp, A., Santos, F., Hugenholtz, J., & Smid, E. J. (2008). Increased folate levels by fermenting melon juice.
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