mw. dr. A.M. (Anne Marije) Kaag

  • Faculteit der Maatschappij- en Gedragswetenschappen
    Programmagroep: Developmental Psychology
  • Bezoekadres
    REC G
    Nieuwe Achtergracht 129  
  • Postadres:
    Postbus  15916
    1001 NK  Amsterdam

            As a cognitive neuroscientist show specializes in addiction research,  I am intrigued about why people continue certain behavior despite all the negative consequences. In May 2016 I successfully defended my PhD dissertation: “Are Cocaine Users Too Sensitive?”.  In this research, I combined several MRI techniques (structural MRI,  functional MRI and magnetic resonance spectrograph) for identifying abnormalities in the neurobiological mechanisms that underlie maladaptive (emotional) memories in regular cocaine users. As a postdoctoral researcher on a collaborative project between the Academic Medical  Center (Professor Goudriaan), VU Medical Center  (Professor de Vries, dr. Pattij) and the University of Amsterdam (Professor Wiers), my next aim is to develop  novel  working-memory based interventions that target these maladaptive memories, using a translational approach. Based on the first successful findings of these studies, we will soon start a novel fMRI project to identify the neural mechanisms that underlie the interaction between working memory and maladaptive memories in regular cocaine users (supported by an ABC talent grant) and adults with ADHD.

In addition to this main research theme,  I am interested in the relation between polysubstance use and structural alterations in the brain. The reason for this is that many substances are actually polysubstance users (that is, for instance,  using alcohol and cannabis in addition to cocaine on a regular basis) but this aspect has been highly disregarded in scientific research. More insight into the neurobiological profile of polysubstance users may contribute to the development of better treatment strategies in this population. 



  • Kaag, A. M., Wiers, R. W., de Vries, T. J., Pattij, T., & Goudriaan, A. E. (2018). Striatal alcohol cue-reactivity is stronger in male than female problem drinkers. European Journal of Neuroscience. DOI: 10.1111/ejn.13991 
  • Kaag, A. M., Schulte, M. H. J., Jansen, J. M., van Wingen, G., Homberg, J., van den Brink, W., ... Reneman, L. (2018). The relation between gray matter volume and the use of alcohol, tobacco, cocaine and cannabis in male polysubstance users. Drug and Alcohol Dependence, 187, 186-194. DOI: 10.1016/j.drugalcdep.2018.03.010  [details] 
  • Kaag, A. M., Goudriaan, A. E., de Vries, T. J., Pattij, T., & Wiers, R. W. (2018). A high working memory load prior to memory retrieval reduces craving in non-treatment seeking problem drinkers. Psychopharmacology, 235(3), 695-708. DOI: 10.1007/s00213-017-4785-4  [details] 


  • Schulte, M. H. J., Kaag, A. M., Wiers, R. W., Schmaal, L., van den Brink, W., Reneman, L., ... Goudriaan, A. E. (2017). Prefrontal Glx and GABA concentrations and impulsivity in cigarette smokers and smoking polysubstance users. Drug and Alcohol Dependence, 179, 117-123. DOI: 10.1016/j.drugalcdep.2017.06.025  [details] 
  • Kaag, A. M., van Wingen, G. A., Caan, M. W. A., Homberg, J. R., van den Brink, W., & Reneman, L. (2017). White matter alterations in cocaine users are negatively related to the number of additionally (ab)used substances. Addiction Biology, 22(4), 1048–1056. DOI: 10.1111/adb.12375  [details] 
  • Schulte, M. H. J., Goudriaan, A. E., Kaag, A. M., Kooi, D. P., van den Brink, W., Wiers, R. W., & Schmaal, L. (2017). The effect of N-acetylcysteine on brain glutamate and gamma-aminobutyric acid concentrations and on smoking cessation: A randomized, double-blind, placebo-controlled trial. Journal of Psychopharmacology, 31(10), 1377-1379. DOI: 10.1177/0269881117730660  [details] 


  • Kaag, A. M., Levar, N., Woutersen, K., Homberg, J., van den Brink, W., Reneman, L., & van Wingen, G. (2016). Hyperresponsiveness of the Neural Fear Network During Fear Conditioning and Extinction Learning in Male Cocaine Users. The American Journal of Psychiatry, 173(10), 1033-1042. DOI: 10.1176/appi.ajp.2016.15040433  [details] 
  • Kaag, A. M., Schluter, R. S., Karel, P., Homberg, J., van den Brink, W., Reneman, L., & van Wingen, G. A. (2016). Aversive Counterconditioning Attenuates Reward Signaling in the Ventral Striatum. Frontiers in Human Neuroscience, 10, [418]. DOI: 10.3389/fnhum.2016.00418  [details] 


  • Crunelle, C. L., Kaag, A. M., van den Munkhof, H. E., Reneman, L., Homberg, J. R., Sabbe, B., ... van Wingen, G. (2015). Dysfunctional amygdala activation and connectivity with the prefrontal cortex in current cocaine users. Human Brain Mapping, 36(10), 4222-4230. DOI: 10.1002/hbm.22913  [details] 


  • Kaag, A. M., Crunelle, C. L., van Wingen, G. A., Homberg, J., van den Brink, W., & Reneman, L. (2014). Relationship between trait impulsivity and cortical volume, thickness and surface area in male cocaine users and non-drug using controls. Drug and Alcohol Dependence, 144, 210-217. DOI: 10.1016/j.drugalcdep.2014.09.016  [details] 
  • Crunelle, C. L., Kaag, A. M., van Wingen, G. A., van den Munkhof, H. E., Homberg, J. R., Reneman, L., & van den Brink, W. (2014). Reduced frontal brain volume in non-treatment-seeking cocaine-dependent individuals: Exploring the role of impulsivity, depression, and smoking. Frontiers in Human Neuroscience, 8, [7]. DOI: 10.3389/fnhum.2014.00007  [details] 


  • Schouw, M. L. J., De Ruiter, M. B., Kaag, A. M., van den Brink, W., Lindauer, R. J. L., & Reneman, L. (2013). Dopaminergic dysfunction in abstinent dexamphetamine users: Results from a pharmacological fMRI study using a reward anticipation task and a methylphenidate challenge. Drug and Alcohol Dependence, 130(1-3), 52-60. DOI: 10.1016/j.drugalcdep.2012.10.010  [details] 
  • Schouw, M. L. J., Kaag, A. M., Caan, M. W. A., Heijtel, D. F. R., Majoie, C. B. L. M., Nederveen, A. J., ... Reneman, L. (2013). Mapping the hemodynamic response in human subjects to a dopaminergic challenge with dextroamphetamine using ASL-based pharmacological MRI. NeuroImage, 72, 1-9. DOI: 10.1016/j.neuroimage.2012.12.056  [details] 
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