Certain antiepileptic drugs (e.g. carbamazepine and lamotrigine) block sodium channels in an use-dependent manner and this mechanism contributes to the anti-convulsant properties of these drugs. There are, however, subtle differences in sodium current blocking properties of the antiepileptic drugs when they interact with the different brain sodium channel α-subunits.
In his research, Xin Qiao attempts to show that a deeper and more complete understanding of how antiepileptic drugs interact with different sodium channel α-subunits and different neuron types can facilitate the development of new antiepileptic drugs with improved therapeutic efficacy.
Ms Xin Qiao: Antiepileptic drugs targeting sodium channels. Subunit and
neuron-type specific interactions.
The supervisor is Prof. W. J. Wadman and the co-supervisor is Dr T. R. Werkman.
The ceremony is open to the general public.