Marc Hogenbirk’s research is focused on B cell non-Hodgkin lymphomas, which are derived from germinal centres. Germinal centres are defined histological structures that develop during an immune response in secondary lymphatic tissues, such as of lymph nodes, spleens or Peyer’s Patches. By investigating DNA binding profiles of activation-induced cytidine deaminase (AID), a protein central in the mutagenesis process, Hogenbirk seeks to answer how this mutagenesis process is targeted throughout the genome, which (onco)genes are unintentionally mutated by AID and how it contributes to genetic instability and especially chromosomal translocations.
M.A. Hogenbirk, Defining Risk Factors for Genomic Instability in B Cells: Novel Insights from NGS-Based Technologies.
Prof. A.J.M. Berns (NKI-AvL)
Dr H.B. Jacobs (NKI-AvL)
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