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Marc Hogenbirk’s research is focused on B cell non-Hodgkin lymphomas, which are derived from germinal centres. Germinal centres are defined histological structures that develop during an immune response in secondary lymphatic tissues, such as of lymph nodes, spleens or Peyer’s Patches. By investigating DNA binding profiles of activation-induced cytidine deaminase (AID), a protein central in the mutagenesis process, Hogenbirk seeks to answer how this mutagenesis process is targeted throughout the genome, which (onco)genes are unintentionally mutated by AID and how it contributes to genetic instability and especially chromosomal translocations.

Event details of Genomic instability in B cells
Date 26 November 2013
Time 10:00 -11:00
Location Agnietenkapel

M.A. Hogenbirk, Defining Risk Factors for Genomic Instability in B Cells: Novel Insights from NGS-Based Technologies.

Supervisor

Prof. A.J.M. Berns (NKI-AvL)

Co-supervisor

Dr H.B. Jacobs (NKI-AvL)

Agnietenkapel

Oudezijds Voorburgwal 229 - 231
1012 EZ Amsterdam

Entrance

This event will be open to the public.