Phosphoinositides are implicated in virtually all aspects of cellular warfare. They help to maintain the structure of biomembranes, but are also essential signal transduction molecules. This is illustrated by Ptdlns(4,5)P2, a versatile and important phosphoinositide that regulates many cellular processes, including cell survival, calcium homeostasis, vesicular trafficking, cytokinesis, stress responses and cell adhesion. Willem-Jan Keune examines the biochemical and functional aspects of Ptdlns5P and the PIP4Ks that determine its level in the cell.
W.J.H. Keune, Phospoinositides and Lipid Kinases in Oxidative Stress Signalling and Cancer.
Prof. G.J. Borst
Dr N. Divecha (NKI-AVL)
This event will be open to the public.