In many cases, the methods commonly used to obtain detailed structural data on protein complexes, such as X-ray diffraction, do not work on larger complexes. Other methods such as cryo-electron microscopy are also ineffective. Hansuk Buncherd applies the chemical cross-linking of proteins in combination with mass spectrometry analysis of proteolytic peptides in order to obtain structural data on protein complexes.
H. Buncherd, Development of Enrichment Methods for Cross-Linked Peptides to Study the Dynamic Topology of Large Protein Complexes by Mass Spectrometry.
Prof. C.G. de Koster
Dr L. de Jong
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