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Sabine Krom examines the role of the proteasome in Huntington’s disease (HD) by addressing the following questions: are intracellular polyQ fragments peptidase resistant and aggregation prone? Can we prevent their aggregation by chaperones? Are proteasomes sequestered and inactivated in HD? By answering these questions, Krom hopes to resolve whether proteasomes play a positive or negative role in HD, and whether manipulating proteasomal function can be used as a therapeutic strategy.

Event details of The role of proteasome in Huntington’s disease
Date 18 December 2013
Time 12:00 -13:00
Location Agnietenkapel

S. Krom, The Role of the Proteasome in Huntington’s Disease.


Prof. C.J.F. van Noorden


Dr E.A.J. Reits


Oudezijds Voorburgwal 229 - 231
1012 EZ Amsterdam


This event will be open to the public.