The generation of new neurons continues after birth in a process called adult neurogenesis. Adult neurogenesis takes place in two distinct regions of the brain: the subgranular zone of the hippocampus and the subventricular zone (SVZ). Carlyn Martina-Mamber explores, inter alia, whether the Glial fibrillary acidic protein (GFAP) is also a neural stem cell marker in mice as it is in humans? She also examines whether GFAP is important for adult neurogenesis in the mouse SVZ, as well as the tools that could be employed to specifically modulate GFAP isoform expression within the adult mouse SVZ? The research in this thesis was financially supported by Alzheimer Nederland.
C.E. Martina-Mamber, GFAP as an Understudy in Adult Neurogenisis.
Prof. E.M. Hol
Dr W. Kamphuis (KNAW)
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