A structural change in diameter of arteries involves reorganization of both cells and extracellular matrix components. This process is known as vascular remodeling. Such remodeling occurs in hypertension, under low flow following prolonged stimulation by vasoconstrictors. For her thesis, Bilge Güvenç Tuna focuses on the role of contractile plasticity of smooth muscle cells (SMC) in inward remodeling of small arteries. Such contractile plasticity is defined as a change of the diameter-dependent capacity for active force generation.