Joris van der Heijden describes several novel as well as previously known genetic variations in FcγRs (Fc gamma receptors) and their functional and/or clinical importance. In addition to showing that the effect of polymorphisms do not necessarily only affect the receptor itself, but can also influence the cooperation with other FcγRs, Van der Heijden also throws light on how another protein, SIRPa, can inhibit signaling by FcγRs.
J. van der Heijden, Genetic Variation in Human Fc Gamma Receptors: Functional Consequences of Polymorphisms and Copy Number Variation.
Prof. T.W. Kuijpers
Dr T.K. van den Berg
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