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The interaction of a cell with its environment occurs at the cell membrane. Typically, binding of a signal ligand to a protein receptor introduces a change in the receptor that propagates to the cytoplasmic end of the receptor, causing binding or release of a second ligand. Such long-distance signal propagation through the receptor is referred to as the allosteric effect. Understanding the mechanism of the allosteric effect in membrane proteins is fundamentally important for modern drug design/discovery. Lizhe Zhu investigates the allosteric mechanism of bacterial chemoreceptors via all-atom Molecular Dynamics simulations of the HAMP domains - the signal conversion module of these receptors.

Event details of Molecular simulations of receptor proteins
Date 5 September 2014
Time 14:00 -15:00
Location Agnietenkapel

L. Zhu, Communicating Helices: Molecular Simulation of Allosteric Receptor Proteins.

Supervisor

Prof. P.G. Bolhuis

Co-supervisor

Dr J. Vreede

Agnietenkapel

Oudezijds Voorburgwal 229 - 231
1012 EZ Amsterdam

Entrance

This event is open to the public.