Dendritic cells (DCs) are the sentinels of the immune system. They scout the body for possible forms of danger and are ready to initiate and guide a tailored immune response depending on the nature of the threat. Due to their pivotal role in shaping innate and adaptive immune responses, DCs have been implicated in autoimmune diseases where they present self-antigens to autoreactive T cells. The ligand Flt3L is a crucial growth factor in the development of DCs. Inês Ramos explores the role of Flt3L-dependent DCs in rheumatic diseases.
M.I.P.M. Ramos, Dendritic Cells Manipulating Immune Responses: Understanding the Role of Flt3L and Flt3-dependent DCs in Rheumatic Diseases.
Prof. P.P. Tak
Dr M.C. Lebre
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