To ensure a timely intervention in the case of Alzheimer’s disease, insight is needed into the molecular processes taking place in Alzheimer’s. One of these processes is the unfolded protein response (UPR) of the endoplasmic reticulum (a network of membranes in a cell’s cytoplasm). The UPR is ‘on’ in the early stages of the disease, which is associated with a rise in the transport protein Rab6. Hyung Elfrink explores the function of this protein in proteostatic systems with regard to Alzheimer’s.
H.L. Elfrink, Rab6 and Unfolded Protein Response-mediated Proteostasis in Alzheimer’s Disease.
Prof. F. Baas
Dr W. Scheper (Center for Neurogenomics and Cnitive Research)
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