The worldwide emergence and spread of antibiotic resistant bacteria represent a major threat to human health care as the chance of therapy failure and costs for treatment increase. Development of innovative countermeasures depends on a deeper understanding of how sensitive and drug resistant bacteria respond to different drug levels, circumvent metabolic costs and the development of knowledge of the factors that can affect the acquisition of drug resistance. Nadine Händel characterises and quanitifies the relationship between antibiotic usage and development and transmission of resistance using laboratory cultures of E. coli as a model.
N. Händel, Quantitative Relationship Between Antibiotic Exposure and the Acquisition and Transmission of Resistance in Bacteria in the Laboratory.
Prof. S. Brul
Dr B.H. Ter Kuile
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