Barry Mook carries out research into bacterial meningitis, which continues to exact a heavy toll, even in developed countries. Around 80% of cases in Europe and the United States are caused by Streptococcus pneumoniae and Neisseria meningitis. Despite advances in medical care, mortality from pneumococcal meningitis ranges from 16 to 37%. Mook focuses on current understandings of the pathophysiology and pathogenic mechanisms associated with pneumococcal meningitis. He also discusses targets for future therapeutic strategies.