Since the discovery of HIV-1 as a cause of aids, many antiretroviral pharmaceuticals have been developed to target viral replication. The combination of at least three antiretroviral drugs, preferably from at least two different classes, has become standard practice and is known as Highly Active Anti-Retroviral Treatment (HAART). However, despite the success of the treatment, patients do often suffer drug-induced adverse events, some of which can be life threatening. The aim of Ruben Smith’s research is to clarify the short term effects of antiretroviral drugs in order to understand the mechanisms underlying the toxicity that causes such adverse events.
R.L. Smith: Towards an Understanding of the Side Effects of Anti-HIV Drugs Using Caenorhabditis Elegans.
Prof. S. Brul
Dr J.C. van der Spek
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