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Protein function depends on the respective polypeptide chain forming a unique and well-defined three-dimensional conformation. In complex cell environments, the spontaneous unassisted folding of proteins is particularly prone to misfolding. Molecular chaperones suppress these anomalies by interacting with the newly synthesised polypeptide chains to assist in their folding. Different chaperones are involved at different stages of protein folding and stabilisation of cells. Kushagra Singhal uses molecular simulations to gain a better insight into the dynamics and properties of one of these chaperone proteins, known as the Trigger Factor.

Event details of The dynamics of a molecular chaperone
Date 28 April 2016
Time 10:00 -11:00
Location Agnietenkapel
Room Location

K. Singhal: From Flexibility to Function. Molecular Dynamics Simulations of Conformational Changes in Chaperones and Photoreceptors.

Supervisor

Prof. P.G. Bolhuis

Co-supervisor

Dr J. Vreede

Agnietenkapel

Room Location

Oudezijds Voorburgwal 229 - 231
1012 EZ Amsterdam

Entrance

This event is open to the public.