Protein function depends on the respective polypeptide chain forming a unique and well-defined three-dimensional conformation. In complex cell environments, the spontaneous unassisted folding of proteins is particularly prone to misfolding. Molecular chaperones suppress these anomalies by interacting with the newly synthesised polypeptide chains to assist in their folding. Different chaperones are involved at different stages of protein folding and stabilisation of cells. Kushagra Singhal uses molecular simulations to gain a better insight into the dynamics and properties of one of these chaperone proteins, known as the Trigger Factor.
K. Singhal: From Flexibility to Function. Molecular Dynamics Simulations of Conformational Changes in Chaperones and Photoreceptors.
Prof. P.G. Bolhuis
Dr J. Vreede
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