Patients in intensive care benefit from a rapid normalisation of macrohemodynamic parameters. Unfortunately, despite optimal management of these parameters, some patents still develop organ failure. To prevent this, something else is required, namely restoration of microcirculation. Abele Donati asks if monitoring microcirculation can help physicians to treat critically ill patients. New techniques allow them to observe the physiopathological alterations and study the effects of therapies aimed at fixing these alterations.