Directly after birth, newborns encounter a wide variety of pathogens in the form of bacteria, viruses and parasites. When immune defenses fail, clinical manifestations of immunodeficiency may develop. Daniel de Klerk studies B cells, which play an important role in the adaptive immune system. A defect in any of the stages of B-cell development can cause primary antibody deficiency (PAD). The aim is to gain knowledge of the pathophysiology and underlying genetic defects, to better understand normal B cell development and differentiation, design diagnostic tests for earlier diagnosis and possibly develop better treatment options.
D.J. aan de Kerk: B Cells Grow Up: Studies of B Cell Activation, Profileration and Differentiation in Primary Antibody Deficiencies.
Prof. T.W. Kuijpers
Dr E.M.M. van Leeuwen
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