Cystic Fibrosis (CF) is a relatively common genetic disorder with high morbidity and mortality. As a consequence of improved therapies, the life expectancy of a CF patient has increased significantly during the last four decades. Improvements in life expectancy have allowed a shift in focus to quality of life factors and disorders impacting this. Maaike Berkhout conducts research into the pathology of the mucosa of the nose and the paranasal sinueses in patients with CF. She also describes the prevalence, the impact on patients and the possible treatment options.