Transcription processing and chromatin structural changes are intertwined processes in the nucleas. Diewertje Piebes focuses on the dynamic interplay of chromatin and its widespread functions such as genome stability and transcription regulation. She studies the effect of targeting the epigenetic regulatory protein Methyl CpG binding protein2 (MeCP2) and measure alterations in chromatin strucutre and transcription regulation in real-time, in order to unravel the causal relationship between the epigenetic chromatim state and transcriptional repression in time and space.
D.G.E. Piebes, Transcription Regulation in Time and Space. Engineered Cell Systems to Modulate the Epigenetic Chromatin Structure: The Role of Methyl-CpG-Binding Protein 2.
Prof. H.V. Westerhoff
Dr P.J. Verschure
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