The mid-and hind brain harbour two essential monoaminergic neuronal populations: the mesodiencephalic dopaminergic (mdDA) neurons in the midbrain and the serotonergic (5HT) neurons in the hindbrain. Both systems innervate multiple regions in the forebrain and are involved in the guidance of our mood, motility and motivation-guided behaviour. Willemieke Kouwenhoven investigates the origin story of the mdDA neuron in order to understand the mdDA system in the healthy, adult brain as well as in the adult brain during pathological conditions.
W.M. Kouwenhoven, The Rise and Fall of Mesodiencephalic Dopaminergic Neurons. Molecular Programming by Transcription Factors Engrailed 1, Pitx3 and Nkx29 During the Development of Mesodiencephalic Neurons.
Prof. M.P. Smidt
Dr L.P. van der Heide