Coordinated contraction of the heart relies on the proper functioning of ion channels that generate the cardiac electrical impulse. Improper regulation of these ion channels can result in a wide variety of cardiac arrhythmias. Several different causes for misregulation of ion channels have been identified, but perhaps the most prominent one lies in our genetic coding. Mutations in the genes encoding for ion channels can cause an imbalance, resulting in altered cardiac condition. Malou van den Bogaard investigates the role of regulatory elements in the noncoding DNA and the effects of genetic variants therein on cardiac ion channel function.