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During inflammation, extensive cell death occurs in the body as a result of toxins excreted by pathogens and the activity of immune cells that combat pathogens by excreting anti-microbial proteins. When the extent of cell death is higher than the body’s clearance capacity, intracellular molecules with pro-inflammatory properties are released into the extracellular environment from dying cells. It is not entirely clear how the release of these molecules is regulated. Gerben Marsman investigates the role played by a specific plasma protein, known as Factor VII activating protease, in the release of chromatin from dead cells.

Event details of Mechanism underlying release of chromatin from dead cells
Date 12 January 2017
Time 12:00 -13:00
Location Agnietenkapel
Room Location

G. Marsman: Factor VII-Activating Protease: Unraveling the Release and Regulation of Dead Cell Nuclear Damps.

Supervisor

Prof. S.M. van Ham

Co-supervisor

Dr B.M. Luken

Agnietenkapel

Room Location

Oudezijds Voorburgwal 229 - 231
1012 EZ Amsterdam

Entrance

This event is open to the public.