Chronic lymphocytic leukemia (CLL) is considered a typical malignancy that not only depends on intrinsic genetic defects, but also relies on interactions with bystander cells in the tumor microenvironment (TME). Signals emanating from local bystander cells provide CLL cells with essential survival and proliferation signals. Martijn van Attekum investigates the reciprocal nature of the signals between CLL cells, T cells and macrophages.
M.H.A. van Attekum. Formation of a Tumor-Supportive Microenvironment in Chronic Lymphocytic Leukemia: Addressing the Reciprocal Interactions in the CLL-T Cell-Macrophage Triad.
Prof. A.P. Kater
Prof. E.F. Eldering
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