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Rheumatoid arthritis (RA) is a debilitating, immune-mediated and inflammatory disorder with a prevalence of 0.5-1% worldwide. Cells known as fibroblast-like synoviocytes (FLS) play a key role in the destructive joint inflammation that is characteristic of RA. These cells display an epigenetically imprinted inflammatory memory that is thought to contribute to the chronicity of the disease. One characteristic of FLS in RA is enhanced expression and activity of histone deacetylases (HDACs), and RA patients can potentially benefit from HDAC inhibitors. However, how these inhibitors modulate inflammatory responses in cell subsets including FLS remains largely unknown. The aim of Chiara Angiolilli’s research is to gain more insight into these mechanisms.

Event details of Modulation of inflammatory responses in rheumatoid arthritis
Date 27 January 2017
Time 10:00 -11:00
Location Agnietenkapel
Room Location

C. Angiolilli: Molecular Mechanisms of Histone Deacetylases in Rheumatoid Arthritis Fibroblast-Like Synoviocytes.

Supervisor

Prof. D.L.P. Baeten

Co-supervisor

Dr K.A. Reedquist (UMC Utrecht)

Agnietenkapel

Room Location

Oudezijds Voorburgwal 229 - 231
1012 EZ Amsterdam

Entrance

This event is open to the public.