Rheumatoid arthritis (RA) is a debilitating, immune-mediated and inflammatory disorder with a prevalence of 0.5-1% worldwide. Cells known as fibroblast-like synoviocytes (FLS) play a key role in the destructive joint inflammation that is characteristic of RA. These cells display an epigenetically imprinted inflammatory memory that is thought to contribute to the chronicity of the disease. One characteristic of FLS in RA is enhanced expression and activity of histone deacetylases (HDACs), and RA patients can potentially benefit from HDAC inhibitors. However, how these inhibitors modulate inflammatory responses in cell subsets including FLS remains largely unknown. The aim of Chiara Angiolilli’s research is to gain more insight into these mechanisms.
C. Angiolilli: Molecular Mechanisms of Histone Deacetylases in Rheumatoid Arthritis Fibroblast-Like Synoviocytes.
Prof. D.L.P. Baeten
Dr K.A. Reedquist (UMC Utrecht)
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