As demonstrated by their evolutionary conservation from yeast to humans and their critical role in a wide array of cellular processes, forkhead (Fox) proteins are seen as critical transcriptional regulators. All members of the Fox family share a conserved 110 amino acid DNA-binding domain that is referred to as the ‘forkhead box’ or ‘winged helix’ domain. The forkhead family of transcription factors has been subdivided into 19 subgroups based on sequence similarity. Ricardo Paap focuses on the subfamily of Forkhead Box O transcription factors.
R.H. Paap, The Diverse Roles of Fox06 in the Developing and Adult Mouse Brain.
Prof. M.P. Smidt
Dr M.F.M. Hoekman
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