Antibodies play a central role in the pathophysiology of many autoimmune diseases. The destructive effects of antibodies is exerted mainly via receptors for immunoglobins, which are expressed on immune cells. Previous research has found that genetic variation in Fc-gamma receptors, which bind immunoglobin G, is associated with susceptibility to various autoimmune diseases. Sietse Nagelkerke studies the complex genetics of Fc-gamma receptors and investigates their role in two autoimmune diseases: Kawasaki disease and systemic lupus erythematosus.
S.Q. Nagelkerke: A Field Guide to Human Fc-gamma Receptors. Genetics, Cellular Expression and Interaction with Immunoglobulins.
Prof. T.W. Kuijpers
Dr T.K. van den Berg
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