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Progressive familial intrahepatic cholestasis type 1(PFIC1), also known as Byler’s disease, causes a build-up of bile in the liver. This disease’s recurrent pattern of cholestatic episodes is similar to that in benign recurrent intrahepatic cholestasis type 1 (BRIC1). Vincent van der Mark looks at the causes of several extrahepatic phenotypes associated with PFIC1 and BRIC1, such as diarrhoea and susceptibility to pulmonary infection. More specifically, he investigates the role played by the protein ATP8B1 in human intestinal, pulmonary and innate immune cells.

Event details of Role of protein ATP8B1 in cholestasis
Date 11 April 2017
Time 10:00 -11:00
Location Agnietenkapel
Room Location

V.A. van der Mark: ATP8B1 and Cellular Trafficking.


Prof. R.P.J. Oude Elferink


Dr C.C. Paulusma


Room Location

Oudezijds Voorburgwal 229 - 231
1012 EZ Amsterdam


This event is open to the public.