Tauopathies comprise a group of neurodegenerative disorders that is characterised by deposits of the tau protein in the brain. Alzheimer’s disease is the best known form of tauopathy. In healthy neurons, tau is regulated by phosporylation and dephosporylation. In tauopathies tau is hyperphosphorylated. Judith van der Harg’s aim is to gain insight into the early underlying mechanism of increased tau phosporylation.