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Red blood cells are equipped with a complex but effective DNA damage response network that can sense, tolerate and repair DNA damage, counteracting the accumulation of potentially mutagenic DNA lesions and mutations. Alessandra Buoninfante studies the function and regulation of factors involved in DNA Damage Tolerance (DDT). Specific aspects she investigates include the molecular and developmental consequences of DDT inactivation and the potential for exploring tumour-specific DDT-defects for cancer therapy.

Event details of Functions and regulation of DNA damage response network
Date 5 July 2018
Time 12:00 -13:00
Location Agnietenkapel
Room Location

O.A. Buoninfante: Physiological and Pharmacological Relevance of DNA Damage Tolerance. 


Prof. J. Borst


Dr H.B. Jacobs (NKI-AvL)


Room Location

Oudezijds Voorburgwal 229 - 231
1012 EZ Amsterdam


This event is open to the public.