The blood-retinal barrier (BRB) is formed by the retinal vascular endothelium and is regulated by the neurovascular unit, which is a cellular complex of endothelial cells, glial cells and pericytes. It protects the neural retina against disturbances of homeostasis, and from potentially harmfull substances in the circulation. Anne-Eva van der Wijk describes the formation of the BRB during early development at cellular and molecular levels, and evaluates the contribution and possible mechanisms of inflammatory conditions in the development of diabetic macular edema (DME) and diabetic retinopathy (DR).
A. van der Wijk, You Build Me Up, You Break Me Down. Molecular Mechanisms of Blood-Retinal Barrier Development and Disruption.
Prof. R.O. Schlingemann
Prof. C.J.F. van Noorden
Dr I. Klaassen
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