Frank de Jong studies the workings of financial markets, the pricing of assets and the use of financial instruments to manage risk. De Jong is also an active member of Netspar, a network for research into pensions and the ageing population.

De Jong has been affiliated with Tilburg University as a professor of Financial Markets and Risk Management since 2005. Prior to this, he was affiliated with the UvA, where he was professor of Finance and Insurances from 2001 to 2007. During this period, de Jong also worked as a guest researcher at several institutions, including Princeton University (US) and the Institute for Financial Research in Stockholm, Sweden. In 2013, de Jong was awarded a Wim Duisenberg Research Fellowship, which is a grant awarded by the European Central Bank (ECB) to economists conducting research into areas deemed relevant by the ECB.

De Jong co-authored the book The Microstructure of Financial Markets, published by Cambridge University Press. He has also written articles published in prominent academic journals such as the Journal of Finance, the Journal of Financial Economics and the Journal of Financial and Quantitative Analysis. His articles have also appeared in other publications, including the Dutch professional journal Economisch Statistische Berichten. De Jong is also co-editor of the editorial staff of De Economist.