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Ms A.M. (Adela) Isvoranu MSc

Faculty of Social and Behavioural Sciences
Programme group Psychological Methods

Visiting address
  • Nieuwe Achtergracht 129
Postal address
  • Postbus 15906
    1001 NK Amsterdam
Contact details
  • About

    I am a PhD student at the University of Amsterdam, within the Psychological Methods Research group. My research is funded by an NWO Talent Grant and it is concerned with the application of network analysis to psychiatric disorders. My work so far has been looking at interrelations between environmental exposure and symptoms of psychotic disorders.

     

  • News

    Our two new papers discussing the application of network analysis to psychiatry research are now published as advance access in the journal Schizophrenia Bulletin.

    The first paper (pdf) is a brief theoretical framework describing how the network approach can be used to investigate the interplay between environmental risk factors, expression of psychosis, and symptoms of general psychopathology. We provide an example network constructed from the Early Developmental Stages of Psychopathology (EDSP) study in order to determine the network structure pertaining to three environmental risk factors (cannabis use, developmental trauma, urban environment), dimensional measures of psychopathology, and one composite measure of psychosis expression. The results suggest that network models can successfully serve to disentangle the mechanisms that underlie this interplay: Environmental factors may (1) exert main effects on specific (sets of) symptoms, which subsequently spread through the symptom network and (2) increase the strength of interactions between symptoms, leading to a more strongly connected and less resilient network structure. 

     

    The second paper (pdf) is a detailed study concerned with potential pathways between childhood trauma and psychotic experiences, investigated from a network perspective. We used data from patients diagnosed with a psychotic disorder from the longitudinal observational study Genetic Risk an Outcome of Psychosis Project and included the five scales of the Childhood Trauma Questionnaire-Short Form and all original symptom dimensions of the Positive and Negative Syndrome Scale as nodes in our network. The results show that childhood trauma is connected to the positive and negative symptoms of psychosis only through symptoms of general psychopathology. To highlight these pathways, we further constructed shortest path networks showing the quickest routes from each trauma node to each of the positive and negative symptoms. Overall, our findings suggest that several symptoms of general psychopathology may mediate the relationship between trauma and psychosis, providing evidence for an affective pathway to psychosis and re-emphasizing questions regarding the specificity of trauma to psychosis. A poster highlighting the main results of this study can be accessed here.

     

    Isvoranu, A. M., Borsboom, D., van Os, J. & Guloksuz, S. (2016). A Network Approach to Environmental Impact in Psychotic Disorder: Brief Theoretical Framework. Schizophrenia Bulletin, Advance Access published May 13, 2016. 

    Isvoranu, A. M., van Borkulo, C. D., Boyette, L., Wigman, J. T. W., Vinkers, C. H., Borsboom, D. (2016). A Network Approach to Psychosis: Pathways Between Childhood Trauma and Psychotic Symptoms. Schizophrenia Bulletin, Advance Access published May 10, 2016.

  • Website
  • Publications

    2019

    2018

    • Boyette, L. L. N. J., Isvoranu, A. M., Schirmbeck, F., Velthorst, E., Simons, C., Borsboom, D., & de Haan, L. J. (2018). Pathways from speech illusions to psychotic symptoms in subjects at Ultra-High Risk for psychosis: combining an experimental measure of aberrant experiences with network analysis. Schizophrenia Bulletin, 44, S269. [F126].
    • Epskamp, S., van Borkulo, C. D., Van der Veen, D. C., Servaas, M. N., Isvoranu, A-M., Riesse, H., & Cramer, A. O. J. (2018). Personalized Network Modeling in Psychopathology: The Importance of Contemporaneous and Temporal Connections. Clinical Psychological Science, 6(3), 416-427. https://doi.org/10.1177/2167702617744325 [details]
    • Fonseca-Pedrero, E., Ortuño, J., Debbané, M., Chan, R. C. K., Cicero, D., Zhang, L. C., ... Fried, E. I. (2018). The Network Structure of Schizotypal Personality Traits. Schizophrenia Bulletin, 44(2, Supplement), S468–S479. https://doi.org/10.1093/schbul/sby044 [details]
    • van Rooijen, G., Isvoranu, A. M., Kruijt, O. H., van Borkulo, C. D., Meijer, C. J., Wigman, J. T. W., ... Bartels-Velthuis, A. A. (2018). A state-independent network of depressive, negative and positive symptoms in male patients with schizophrenia spectrum disorders. Schizophrenia Research, 193, 232-239. https://doi.org/10.1016/j.schres.2017.07.035 [details]

    2017

    • Isvoranu, A-M., van Borkulo, C. D., Boyette, L-L., Wigman, J. T. W., Vinkers, C. H., & Borsboom, D. (2017). A Network Approach to Psychosis: Pathways Between Childhood Trauma and Psychotic Symptoms. Schizophrenia Bulletin, 43(1), 187-196. https://doi.org/10.1093/schbul/sbw055 [details]
    • van Rooijen, G., Isvoranu, A-M., Meijer, C. J., van Borkulo, C. D., Ruhé, H. G., de Haan, L., & GROUP investigators (2017). A symptom network structure of the psychosis spectrum. Schizophrenia Research, 189, 75-83. https://doi.org/10.1016/j.schres.2017.02.018 [details]

    2016

    • Isvoranu, A. M., Borsboom, D., van Os, J., & Guloksuz, S. (2016). A Network Approach to Environmental Impact in Psychotic Disorder: Brief Theoretical Framework . Schizophrenia Bulletin, 42(4), 870-873. https://doi.org/10.1093/schbul/sbw049 [details]

    2019

    • Isvoranu, A. M., Boyette, L. L. N. J., Guloksuz, S., & Borsboom, D. (Accepted/In press). Network Models of Psychosis. In Dimensions of Psychosis: comprehensive conceptualization and treatments Oxford University Press.

    Award

    • Isvoranu, A. (2019). Best Presentation Award.
    • Isvoranu, A. (2019). James S. McDonnell Foundation (JSMF) Postdoctoral Fellowship Award.
    • Isvoranu, A. (2017). Unilever Research Prize.
    • Isvoranu, A. (2016). Research Priority Area Yield PhD Grant.
    • Isvoranu, A. (2016). NWO Research Talent Grant.
    • Isvoranu, A. (2016). 3rd Place Poster Award.
    • Isvoranu, A. (2015). 2nd Place Poster Award.

    Talk / presentation

    • Epskamp, S. (speaker) & Isvoranu, A. (speaker) (9-12-2019). Network Models of Mental Health, Complex Networks 2019 Satellite: Social Good, Carcavelos, Portugal.
    • Isvoranu, A. (speaker) (2-10-2019). Cannabis (ab)use in psychosis, Conference on Complex Systems 2019, Singapore, Singapore.
    • Isvoranu, A. (speaker) & Epskamp, S. (speaker) (18-9-2019). Complexities of mental health: Towards the use of network models in therapy., Complexity Institute.
    • Isvoranu, A. (speaker) (8-3-2019). State of the Art and Clinical Applications of Network Psychometrics, International Convention of Psychological Science (2019), Paris, France.
    • Isvoranu, A. (speaker) (27-9-2018). Towards a Dynamical Systems Approach to Mental Disorders, Conference on Complex Systems 2018, Thessaloniki, Greece.
    • Isvoranu, A. (speaker) (10-7-2018). Network Analysis in JASP, 83rd annual International Meeting of the Psychometric Society, New York City, United States.
    • Isvoranu, A. (speaker) (25-5-2018). Big5 in Schizophrenia: Personality through Exploratory Structural Equation Modeling and Network Analysis, 30th Annual Convention of the Association for Psychological Science, San Francisco, United States.
    • Isvoranu, A. (speaker) (29-3-2018). Network Models of Psychosis, Department of General Psychiatry, Institute of Mental Health, Singapore, Singapore..
    • Isvoranu, A. (speaker) (21-3-2018). A (Data Driven) Network Approach to Schizophrenia, Complexities of Time.
    • Isvoranu, A. (speaker) (30-6-2017). Towards Incorporating Genetic Risk Scores into Network Models of Psychosis, Behaviour Genetics Association Annual Meeting, Oslo, Norway.

    Others

    • Isvoranu, A. (organiser) & Epskamp, S. (organiser) (1-11-2019). Network Psychometrics Workshop, Taipei. Organized one-day workshop. (organising a conference, workshop, ...).
    • Isvoranu, A. (organiser), Hoekstra, R. H. A. (organiser) & Epskamp, S. (organiser) (24-6-2019 - 28-6-2019). Psychological Networks Amsterdam Summer School 2019, Amsterdam, Netherlands (organising a conference, workshop, ...).
    • Isvoranu, A. (organiser), Hoekstra, R. H. A. (organiser) & Epskamp, S. (organiser) (28-1-2019 - 1-2-2019). Psychological Networks Amsterdam Winter School 2019, Amsterdam, Netherlands (organising a conference, workshop, ...).
    • Epskamp, S. (participant) & Isvoranu, A. M. (participant) (27-8-2018 - 1-9-2018). Psychological Networks Amsterdam Summer School 2018, Amsterdam, Netherlands. Host and organization (organising a conference, workshop, ...).
    • Isvoranu, A. (participant) (29-1-2018 - 2-2-2018). Psychological Networks Summer & Winter School, Amsterdam, Netherlands (organising a conference, workshop, ...).
    • Epskamp, S. (organiser) & Isvoranu, A. M. (organiser) (29-1-2018 - 2-2-2018). Psychological Networks Summer & Winter School, Amsterdam, Netherlands. Winter school (organising a conference, workshop, ...).
    • Isvoranu, A. (participant) (17-9-2017). Conference on Complex Systems. Cancun, Mexico, Cancun, Mexico. Poster Presentation (participating in a conference, workshop, ...).
    • Isvoranu, A. (organiser) (28-8-2017 - 1-9-2017). Psychological Networks Amsterdam Summer School 2017 (organising a conference, workshop, ...).
    • Epskamp, S. (organiser) & Isvoranu, A. M. (organiser) (28-8-2017 - 1-9-2017). Psychological Networks Amsterdam Summer School 2017. Psychological Networks Amsterdam Summer School 2017 (organising a conference, workshop, ...).
    • Isvoranu, A. (participant) (18-7-2017 - 21-7-2017). International Meeting of the Psychometric Society 2017, Zürich, Switzerland (participating in a conference, workshop, ...).
    • Isvoranu, A. (participant) (19-9-2016 - 22-9-2016). Conference on Complex Systems 2016, Amsterdam (participating in a conference, workshop, ...).
    This list of publications is extracted from the UvA-Current Research Information System. Questions? Ask the library or the Pure staff of your faculty / institute. Log in to Pure to edit your publications. Log in to Personal Page Publication Selection tool to manage the visibility of your publications on this list.
  • Ancillary activities
    • No ancillary activities