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Dr. T.R. (Taco) Werkman

Faculteit der Natuurwetenschappen, Wiskunde en Informatica
Swammerdam Institute for Life Sciences

  • Science Park 904
  • Kamernummer: C3.266
  • Postbus 94246
    1090 GE Amsterdam
  • The endocannabinoid system and epilepsy

    The endocannabinoid research line was started as part of a project financed by Top Institute Pharma (TIP), where we studied  the role of endocannabinoid (eCB) in signalling processes in the prefrontal cortex (PFC). One of the main findings of that research was that intracellular CB2 receptors in layer 2/3 neurons of the PFC are involved in regulating neuronal excitability.

    In a follow-up study (financed by the Dutch Epilepsy Fund) we are now studying the role of the eCB system in epilepsy.

    The project has two topics:

    (1) the role of the endocannabinoid CB1 receptor in cortical development and epileptogenesis (Focal Cortical Dysplasia) and

    (2) CB2 receptors controlling epileptic activity.


  • Publicaties


    • van der Velden, L., Vinck, M. A., Werkman, T. R., & Wadman, W. J. (2019). Modulation of Functional Connectivity Between Dopamine Neurons of the Rat Ventral Tegmental Area in vitro. Frontiers in Integrative Neuroscience, 13, [20]. https://doi.org/10.3389/fnint.2019.00020 [details]



    • Cappaert, N. L. M., Werkman, T. R., Benito, N., Witter, M. P., Baayen, J. C., & Wadman, W. J. (2016). Carbamazepine modulates the spatiotemporal activity in the dentate gyrus of rats and pharmacoresistant humans in vitro. Brain and Behavior, 6(6), [e00463]. https://doi.org/10.1002/brb3.463 [details]


    • Baggelaar, M. P., Chameau, P. J. P., Kantae, V., Hummel, J., Hsu, K. L., Janssen, F., ... van der Stelt, M. (2015). Highly Selective, Reversible Inhibitor Identified by Comparative Chemoproteomics Modulates Diacylglycerol Lipase Activity in Neurons. Journal of the American Chemical Society, 137(27), 8851-8857. https://doi.org/10.1021/jacs.5b04883 [details]
    • den Boon, F. S., Werkman, T. R., Schaafsma-Zhao, Q., Houthuijs, K., Vitalis, T., Kruse, C. G., ... Chameau, P. (2015). Activation of type-1 cannabinoid receptor shifts the balance between excitation and inhibition towards excitation in layer II/III pyramidal neurons of the rat prelimbic cortex. Plügers Archiv, 467(7), 1551-1564. https://doi.org/10.1007/s00424-014-1586-z [details]


    • Qiao, X., Sun, G., Clare, J. J., Werkman, T. R., & Wadman, W. J. (2014). Properties of human brain sodium channel α-subunits expressed in HEK293 cells and their modulation by carbamazepine, phenytoin and lamotrigine. British Journal of Pharmacology, 171(4), 1054-1067. https://doi.org/10.1111/bph.12534 [details]
    • den Boon, F. S., Chameau, P., Houthuijs, K., Bolijn, S., Mastrangelo, N., Kruse, C. G., ... Werkman, T. R. (2014). Endocannabinoids produced upon action potential firing evoke a Cl− current via type-2 cannabinoid receptors in the medial prefrontal cortex. Plügers Archiv, 466(12), 2257-2268. https://doi.org/10.1007/s00424-014-1502-6 [details]


    • Qiao, X., Werkman, T. R., Gorter, J. A., Wadman, W. J., & van Vliet, E. A. (2013). Expression of sodium channel α subunits 1.1, 1.2 and 1.6 in rat hippocampus after kainic acid-induced epilepsy. Epilepsy Research, 106(1-2), 17-28. https://doi.org/10.1016/j.eplepsyres.2013.06.006 [details]


    • den Boon, F. S., Chameau, P., Schaafsma-Zhao, Q., van Aken, W., Bari, M., Oddi, S., ... Werkman, T. R. (2012). Excitability of prefrontal cortical pyramidal neurons is modulated by activation of intracellular type-2 cannabinoid receptors. Proceedings of the National Academy of Sciences of the United States of America, 109(9), 3534-3539. https://doi.org/10.1073/pnas.1118167109 [details]
    • van der Velden, L., Vinck, M., Werkman, T. R., & Wadman, W. J. (2012). A network of weakly coupled oscillators in the ventral tegmental area. In A. Stett, & G. Zeck (Eds.), MEA Meeting 2012: July 10-July 13, 2012, Reutlingen, Germany: 8th International Meeting on Substrate-Integrated Microelectrode Arrays: proceedings (pp. 140-141). Reutlingen: NMI Natural and Medical Sciences Institute at the University of Tuebingen. [details]


    • Blaazer, A. R., Lange, J. H. M., van der Neut, M. A. W., Mulder, A., den Boon, F. S., Werkman, T. R., ... Wadman, W. J. (2011). Novel indole and azaindole (pyrrolopyridine) cannabinoid (CB) receptor agonists: design, synthesis, structure-activity relationships, physicochemical properties and biological activity. Journal of Medicinal Chemistry, 46, 5086-5098. https://doi.org/10.1016/j.ejmech.2011.08.021 [details]
    • Werkman, T. R., McCreary, A. C., Kruse, C. G., & Wadman, W. J. (2011). NK3 Receptors mediate an increase in firing rate of midbrain dopamine neurons of the rat and the guinea pig. Synapse (New York), 65(8), 814-826. https://doi.org/10.1002/syn.20908 [details]


    • Schenk, G. J., Werkman, T., Wadman, W., Veldhuisen, B., Dijkmans, T. F., Blaas, E., ... Vreugdenhil, E. (2010). Over-expression of the DCLK gene transcript CARP decreases CA3/CA1 network excitability. Brain Research, 1352, 21-34. https://doi.org/10.1016/j.brainres.2010.07.068 [details]


    • Gorter, J. A., Werkman, T. R., & Chameau, P. J. P. (2016). Mogelijk aanknopingspunt voor nieuwe medicijnen Cannabis en epilepsie, een interessant duo. Epilepsie Magazine.
    This list of publications is extracted from the UvA-Current Research Information System. Questions? Ask the library or the Pure staff of your faculty / institute. Log in to Pure to edit your publications. Log in to Personal Page Publication Selection tool to manage the visibility of your publications on this list.
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