|Publicatiedatum||17 februari 2021|
|Sluitingsdatum||15 maart 2021|
|Functieomvang||38 hours per week|
|Salarisindicatie||€2,395 to €3,061 gross per month|
Are you fascinated by fundamental questions in the area of developmental, stem cell and cancer biology and looking for an opportunity to perform challenging research in this area? Would you like to investigate how the same molecular signals can be used over and over again with vastly different outcomes depending on the time and place of their activity? Are you eager to resolve the molecular mechanisms that control these tissue-specific signaling responses? This might be the chance to satisfy your curiosity. We are looking for a PhD student to study the tissue-specific initiation and interpretation of WNT/CTNNB1 signaling.
You will be embedded in the Developmental, Stem Cell and Cancer Biology group (led by dr. Renée van Amerongen), which is part of the Cell & Systems Biology cluster of the Swammerdam Institute for Life Sciences (SILS) in the Faculty of Science at the University of Amsterdam.
Research in our group aims to understand how complex tissues are built and maintained. We study this at multiple different levels – 'from man or mouse to molecule' – using a variety of experimental approaches and with a specific focus on WNT signal transduction, mammary gland biology and breast cancer. See our website for more details: https://www.vanamerongenlab.nl.
The goal of this particular research project is to functionally dissect the cis-acting enhancers that control mammary-specific Wnt gene expression. This project is part of our larger research effort to understand the (epi)genetic regulatory mechanisms that allow individual Wnt genes to display dynamic, but tightly controlled expression patterns in different tissues. Time permitting, you will also help determine how the mammary-specific WNT/CTNNB1 target gene repertoire is activated as part of our larger research effort to understand how WNT signaling activates different gene sets in different tissues.
You are expected to:
You will get the opportunity to:
Our ideal candidate:
We offer a temporary contract for 38 hours per week, preferably starting on 1 May 2021, for the duration of 4 years (the initial contract will be for a period of 18 months and after satisfactory evaluation it will be extended to a total duration of 4 years). This should lead to a dissertation (PhD thesis). We will draft an educational plan that includes attendance of courses and (international) meetings. We also expect you to assist in teaching undergraduates and Master students.
Based on a full-time employment contract (38 hours per week) the gross monthly salary will range from €2,395 in the first year to €3,061 in the last year. This is exclusive 8% holiday allowance and 8,3% end-of-year bonus. A favourable tax agreement, the ‘30% ruling’, may apply to non-Dutch applicants. The Collective Labour Agreement of Dutch Universities is applicable.
Are you curious about our extensive package of secondary employment benefits like our excellent opportunities for study and development? Take a look here.
Do you have questions about this vacancy? Or do you want to know more about our organisation? Please contact:
About the Faculty of Science and the Swammerdam Institute for Life Sciences
The Faculty of Science has a student body of around 7,000, as well as 1,600 members of staff working in education, research or support services. Researchers and students at the Faculty of Science are fascinated by every aspect of how the world works, be it elementary particles, the birth of the universe or the functioning of the brain.
The Swammerdam Institute for Life Sciences (SILS) is one of the largest institutes of the Faculty of Science of the University of Amsterdam (UvA). Its mission is to understand the functioning of living organisms, from the most basic aspects up to complex physiological function(s). Biological processes are studied at the level of molecules, cells, cellular networks and organisms. Similar cellular processes and concepts are studied across different research topics and biological systems, using similar methodologies and technologies. Within the institute, this leads to exchange of information and research over the borders of individual disciplines.
The institute has underpinning technologies that focus on mass spectrometry, genomics and transcriptomics, advanced data analysis and advanced microscopy. Knowledge from adjacent fields of science, in particular biochemistry, biophysics, medicine, bioinformatics, statistics and information technology makes
The UvA is an equal-opportunity employer. We prioritize diversity and are committed to creating an inclusive environment for everyone. We value a spirit of enquiry and perseverance, provide the space to keep asking questions, and promote a culture of curiosity and creativity.
Do you recognize yourself in the job profile? Then we look forward to receiving your application by 15 March 2021. You may apply online by using the link below.
Applications should include:
We will invite potential candidates for interviews in the last two weeks of March 2021.
No agencies please