prof. dr. T.W.J. (Dorus) Gadella


  • Faculty of Science
    Swammerdam Institute for Life Sciences
  • Visiting address
    Science Park A
    Science Park 904  Room number: C2.266
  • Postal address:
    Postbus  94215
    1090 GE  Amsterdam
  • Th.W.J.Gadella@uva.nl
    T: 0205256259

2017

  • Reinhard, N. R., Mastop, M., Yin, T., Wu, Y., Bosma, E. K., Gadella, T. W. J., ... Hordijk, P. L. (2017). The balance between Gαi-Cdc42/Rac and Gα12/13-RhoA pathways determines endothelial barrier regulation by sphingosine-1-phosphate. Molecular Biology of the Cell, 28(23), 3371-3382. DOI: 10.1091/mbc.E17-03-0136  [details] 
  • Mastop, M., Bindels, D. S., Shaner, N. C., Postma, M., Gadella, T. W. J., & Goedhart, J. (2017). Characterization of a spectrally diverse set of fluorescent proteins as FRET acceptors for mTurquoise2. Scientific Reports, 7, [11999]. DOI: 10.1038/s41598-017-12212-x  [details] 
  • Long, Y., Stahl, Y., Weidtkamp-Peters, S., Postma, M., Zhou, W., Goedhart, J., ... Blilou, I. (2017). In vivo FRET–FLIM reveals cell-type-specific protein interactions in Arabidopsis roots. Nature, 548(7665), 97-102. DOI: 10.1038/nature23317  [details] 
  • Vermeer, J. E. M., van Wijk, R., Goedhart, J., Geldner, N., Chory, J., Gadella, T. W. J., & Munnik, T. (2017). In Vivo Imaging of Diacylglycerol at the Cytoplasmic Leaflet of Plant Membranes. Plant and Cell Physiology, 58(7), 1196-1207. DOI: 10.1093/pcp/pcx012  [details] 
  • Bindels, D. S., Haarbosch, L., van Weeren, L., Postma, M., Wiese, K. E., Mastop, M., ... Gadella Jr, T. W. J. (2017). mScarlet: a bright monomeric red fluorescent protein for cellular imaging. Nature Methods, 14(1), 53-56. DOI: 10.1038/nmeth.4074  [details] 

2016

2015

2014

2013

  • Adjobo-Hermans, M. J. W., Crosby, K. C., Putyrski, M., Bhageloe, A., van Weeren, L., Schultz, C., ... Gadella (jr.), T. W. J. (2013). PLCbeta isoforms differ in their subcellular location and their CT-domain dependent interaction with Galphaq. Cellular Signalling, 25(1), 255-263. DOI: 10.1016/j.cellsig.2012.09.022  [details] 
  • Crosby, K. C., Postma, M., Hink, M. A., Zeelenberg, C. H. C., Adjobo-Hermans, M. J. W., & Gadella, T. W. J. (2013). Quantitative analysis of self-association and mobility of annexin A4 at the plasma membrane. Biophysical Journal, 104(9), 1875-1885. DOI: 10.1016/j.bpj.2013.02.057  [details] 
  • Goedhart, J., van Unen, J., Adjobo-Hermans, M. J. W., & Gadella (jr.), T. W. J. (2013). Signaling efficiency of Gαq through its effectors p63RhoGEF and GEFT depends on their subcellular location. Scientific Reports, 3, [2284]. DOI: 10.1038/srep02284  [details] 
  • Pietraszewska-Bogiel, A., Lefebvre, B., Koini, A. M., Klaus-Heisen, D., Takken, F. L. W., Geurts, R., ... Gadella, T. W. J. (2013). Interaction of Medicago truncatula Lysin Motif Receptor-Like Kinases, NFP and LYK3, Produced in Nicotiana benthamiana Induces Defence-Like Responses. PLoS One, 8(6), e65055. DOI: 10.1371/journal.pone.0065055  [details] 
  • Bilan, D. S., Pase, L., Joosen, L., Gorokhovatsky, A. Y., Ermakova, Y. G., Gadella, T. W. J., ... Belousov, V. V. (2013). HyPer-3: A Genetically Encoded H(2)O(2) Probe with Improved Performance for Ratiometric and Fluorescence Lifetime Imaging. ACS Chemical Biology, 8(3), 535-542. DOI: 10.1021/cb300625g  [details] 

2012

  • Goedhart, J., von Stetten, D., Noirclerc-Savoye, M., Lelimousin, M., Joosen, L., Hink, M. A., ... Royant, A. (2012). Structure-guided evolution of cyan fluorescent proteins towards a quantum yield of 93%. Nature Communications, 3, 751. DOI: 10.1038/ncomms1738  [details] 
  • Shcherbakova, D. M., Hink, M. A., Joosen, L., Gadella, T. W. J., & Verkhusha, V. V. (2012). An orange fluorescent protein with a large Stokes shift for single-excitation multicolor FCCS and FRET imaging. Journal of the American Chemical Society, 134(18), 7913-7923. DOI: 10.1021/ja3018972  [details] 
  • von Stetten, D., Noirclerc-Savoye, M., Goedhart, J., Gadella, T. W. J., & Royant, A. (2012). Structure of a fluorescent protein from Aequorea victoria bearing the obligate-monomer mutation A206K. Acta Crystallographica. Section F: Structural Biology and Crystallization Communications, 68(8), 878-882. DOI: 10.1107/S1744309112028667  [details] 

2011

  • Adjobo-Hermans, M. J. W., Goedhart, J., van Weeren, L., Nijmeijer, S., Manders, E. M. M., Offermanns, S., & Gadella (jr.), T. W. J. (2011). Real-time visualization of heterotrimeric G protein Gq activation in living cells. BMC Biology, 9, 32. DOI: 10.1186/1741-7007-9-32  [details] 
  • Crosby, K. C., Pietraszewska-Bogiel, A., Gadella (jr.), T. W. J., & Winkel, B. S. J. (2011). Förster resonance energy transfer demonstrates a flavonoid metabolon in living plant cells that displays competitive interactions between enzymes. FEBS Letters, 585(14), 2193-2198. DOI: 10.1016/j.febslet.2011.05.066  [details] 
  • Goedhart, J., van Weeren, L., Adjobo-Hermans, M. J. W., Elzenaar, I., Hink, M. A., & Gadella (jr.), T. W. J. (2011). Quantitative co-expression of proteins at the single cell level - application to a multimeric FRET sensor. PLoS One, 6(11), [e27321]. DOI: 10.1371/journal.pone.0027321  [details] 
  • Goedhart, J., & Gadella (jr.), T. W. J. (2011). Bypassing GPCRs with chemical dimerizers. Chemistry & Biology, 18(9), 1067-1068. DOI: 10.1016/j.chembiol.2011.09.004  [details] 
  • Pietraszewska-Bogiel, A., & Gadella, T. W. J. (2011). FRET microscopy: from principle to routine technology in cell biology. Journal of Microscopy, 241(2), 111-118. DOI: 10.1111/j.1365-2818.2010.03437.x  [details] 
  • Klarenbeek, J. B., Goedhart, J., Hink, M. A., Gadella, T. W. J., & Jalink, K. (2011). A mTurquoise-based cAMP sensor for both FLIM and ratiometric read-out has improved dynamic range. PLoS One, 6(4), e19170. DOI: 10.1371/journal.pone.0019170  [details] 
  • Klaus-Heisen, D., Nurisso, A., Pietraszewska-Bogiel, A., Mbengue, M., Camut, S., Timmers, T., ... Cullimore, J. V. (2011). Structure-function similarities between a plant receptor-like kinase and the human interleukin-1 receptor-associated kinase-4. The Journal of Biological Chemistry, 286(13), 11202-11210. DOI: 10.1074/jbc.M110.186171  [details] 

2010

  • Alexeeva, S., Gadella (jr.), T. W. J., Verheul, J., Verhoeven, G. S., & den Blaauwen, T. (2010). Direct interactions of early and late assembling division proteins in Escherichia coli cells resolved by FRET. Molecular Microbiology, 77(2), 384-398. DOI: 10.1111/j.1365-2958.2010.07211.x  [details] 
  • Goedhart, J., van Weeren, L., Hink, M. A., Vischer, N. O. E., Jalink, K., & Gadella (jr.), T. W. J. (2010). Bright cyan fluorescent protein variants identified by fluorescence lifetime screening. Nature Methods, 7(2), 137-139. DOI: 10.1038/NMETH.1415  [details] 
  • Schultz, C., Neef, A. B., Gadella (jr.), T. W. J., & Goedhart, J. (2010). Imaging lipids in living cells. Cold Spring Harbor protocols, 8, pdb.top83. DOI: 10.1101/pdb.top83 
  • Schultz, C., Neef, A. B., Gadella (jr.), T. W. J., & Goedhart, J. (2010). Labeling lipids for imaging fixed cells. Cold Spring Harbor protocols, 8, pdb.prot5458. DOI: 10.1101/pdb.prot5458 
  • Schultz, C., Neef, A. B., Gadella (jr.), T. W. J., & Goedhart, J. (2010). Labeling lipids for imaging in live cells. Cold Spring Harbor protocols, 8, pdb.prot5459. DOI: 10.1101/pdb.prot5459 
  • Subach, F. V., Zhang, L., Gadella, T. W. J., Gurskaya, N. G., Lukyanov, K. A., & Verkhusha, V. V. (2010). Red fluorescent protein with reversibly photoswitchable absorbance for photochromic FRET. Chemistry & Biology, 17(7), 745-755. DOI: 10.1016/j.chembiol.2010.05.022  [details] 

2009

  • Vermeer, J. E. M., Thole, J. M., Goedhart, J., Nielsen, E., Munnik, T., & Gadella, T. W. J. (2009). Imaging phosphatidylinositol 4-phosphate dynamics in living plant cells. Plant Journal, 57(2), 356-372. DOI: 10.1111/j.1365-313X.2008.03679.x  [details] 
  • Shcherbo, D., Souslova, E. A., Goedhart, J., Chepurnykh, T. V., Gaintzeva, A., Shemiakina, I. I., ... Chudakov, D. M. (2009). Practical and reliable FRET/FLIM pair of fluorescent proteins. BMC Biotechnology, 9, 24. DOI: 10.1186/1472-6750-9-24  [details] 

2008

  • Adjobo-Hermans, M. J. W., Goedhart, J., & Gadella, T. W. J. (2008). Regulation of PLCβ1a membrane anchoring by its substrate phosphatidylinositol (4,5)-bisphosphate. Journal of Cell Science, 121(22), 3770-3777. DOI: 10.1242/jcs.029785  [details] 
  • Dhonukshe, P., Grigoriev, I., Fischer, R., Tominaga, M., Robinson, D. G., Hašek, J., ... Friml, J. (2008). Auxin transport inhibitors impair vesicle motility and actin cytoskeleton dynamics in diverse eukaryotes. Proceedings of the National Academy of Sciences of the United States of America, 105(11), 4489-4494. DOI: 10.1073/pnas.0711414105  [details] 
  • Kremers, G. J., van Munster, E. B., Goedhart, J., & Gadella, T. W. J. (2008). Quantitative lifetime unmixing of multiexponentially decaying fluorophores using single-frequency fluorescence lifetime imaging microscopy. Biophysical Journal, 95(1), 378-389. DOI: 10.1529/biophysj.107.125229  [details] 
  • Rino, J., Desterro, J. M. P., Pacheco, T. R., Gadella (jr.), T. W. J., & Carmo-Fonseca, M. (2008). Splicing factors SF1 and U2AF associate in extraspliceosomal complexes. Molecular and Cellular Biology, 28(9), 3045-3057. DOI: 10.1128/MCB.02015-07  [details] 
  • Schenning, M., Goedhart, J., Gadella (jr.), T. W. J., Avram, D., Wirtz, K. W. A., & Snoek, G. T. (2008). The anti-apoptotic activity associated with phosphatidylinositol transfer protein α activates the MAPK and Akt/PKB pathway. Biochimica et Biophysica Acta-Molecular Cell Research, 1783(10), 1700-1706. DOI: 10.1016/j.bbamcr.2008.04.014  [details] 
  • Thole, J. M., Vermeer, J. E. M., Zhang, Y., Gadella, T. W. J., & Nielsen, E. (2008). Root hair defective4 encodes a phosphatidylinositol-4-phosphate phosphatase required for proper root hair development in Arabidopsis thaliana. The Plant Cell, 20(2), 381-395. DOI: 10.1105/tpc.107.054304  [details] 

2015

  • Timmerman, I., Heemskerk, N., Kroon, J., Schaefer, A., van Rijssel, J., Hoogenboezem, M., ... van Buul, J. D. (2015). A local VE-cadherin and Trio-based signaling complex stabilizes endothelial junctions through Rac1: Correction. Journal of Cell Science, 128(18), 3514. DOI: 10.1242/jcs.179424 

2010

  • Schultz, C., Neef, A. B., Gadella (jr.), T. W. J., & Goedhart, J. (2010). Transfection of cells with DNA encoding a visible fluorescent protein-tagged lipid-binding domain. Cold Spring Harbor protocols, 8. DOI: 10.1101/pdb.prot5457 

2009

  • Gadella, T. W. J. (2009). FRET and FLIM techniques. (Laboratory techniques in biochemistry and molecular biology; No. 33). Amsterdam: Elsevier. [details] 
  • Goedhart, J., & Gadella (jr.), T. W. J. (2009). Fluorescence resonance energy transfer imaging of PKC signalling in living cells using genetically encoded fluorescent probes. Journal of the Royal Society Interface, 6(S1), S27-S34. DOI: 10.1098/rsif.2008.0340.focus  [details] 

2017

  • van Unen, J. (2017). Spatiotemporal aspects of G protein signaling: Where GPCRs and Rho GTPases meet [details] 
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  • Van Leeuwenhoek Centre Adv. Microscopy
    Directeur
  • Euro-BioImaging Interim Board
    Member

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