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dhr. prof. dr. K.J. (Klaas) Hellingwerf

Faculteit der Natuurwetenschappen, Wiskunde en Informatica
Swammerdam Institute for Life Sciences
Fotograaf: onbekend

  • Science Park 904
  • Kamernummer:
  • Postbus 1212
    1000 BE Amsterdam
  • Profile

    Link to the website of the research group in the Swammerdam Institute

    Molecular Microbial Physiology Group

    Brief professional curriculm vitae

    In the attached document my research interests, successive scientific affiliations, and current formal responsibilities are described in summarized form

    List of publications

    Google Scholar page Hellingwerf

    link to Photanol BV

    Photanol BV

  • Publicaties


    • Luimstra, V. M., Schuurmans, J. M., Verschoor, A. M., Hellingwerf, K. J., Huisman, J., & Matthijs, H. C. P. (2018). Blue light reduces photosynthetic efficiency of cyanobacteria through an imbalance between photosystems I and II. Photosynthesis Research, 138(2), 177-189. DOI: 10.1007/s11120-018-0561-5  [details] 
    • Chen, Q., van der Steen, J. B., Arents, J. C., Hartog, A. F., Ganapathy, S., de Grip, W. J., & Hellingwerf, K. J. (2018). Deletion of sll1541 in Synechocystis sp Strain PCC 6803 Allows Formation of a Far-Red-Shifted holo-Proteorhodopsin In Vivo. Applied and Environmental Microbiology, 84(9). DOI: 10.1128/AEM.02435-17 
    • Lips, D., Schuurmans, J. M., Branco Dos Santos, F., & Hellingwerf, K. J. (2018). Many ways towards 'solar fuel': quantitative analysis of the most promising strategies and the main challenges during scale-up. Energy and Environmental Science, 11(1), 10-22. DOI: 10.1039/c7ee02212c  [details] 


    • Carpine, R., Du, W., Olivieri, G., Pollio, A., Hellingwerf, K. J., Marzocchella, A., & Branco dos Santos, F. (2017). Genetic engineering of Synechocystis sp. PCC6803 for poly-β-hydroxybutyrate overproduction. Algal Research, 25, 117-127. DOI: 10.1016/j.algal.2017.05.013 
    • Schuurmans, R. M., Matthijs, J. C. P., & Hellingwerf, K. J. (2017). Transition from exponential to linear photoautotrophic growth changes the physiology of Synechocystis sp. PCC 6803. Photosynthesis Research, 132(1), 69-82. DOI: 10.1007/s11120-016-0329-8  [details] 
    • Veetil, V. P., Angermayr, S. A., & Hellingwerf, K. J. (2017). Ethylene production with engineered Synechocystis sp PCC 6803 strains. Microbial Cell Factories, 16(1), [34]. DOI: 10.1186/s12934-017-0645-5 
    • Ganapathy, S., Venselaar, H., Chen, Q., de Groot, H. J. M., Hellingwerf, K. J., & de Grip, W. J. (2017). Retinal-based Proton Pumping in the Near Infrared. Journal of the American Chemical Society, 139(6), 2338–2344. DOI: 10.1021/jacs.6b11366  [details] 
    • Du, W., Angermayr, S. A., Jongbloets, J. A., Molenaar, D., Bachmann, H., Hellingwerf, K. J., & Branco Dos Santos, F. (2017). Nonhierarchical Flux Regulation Exposes the Fitness Burden Associated with Lactate Production in Synechocystis sp. PCC6803. ACS Synthetic Biology, 6(3), 395-401. DOI: 10.1021/acssynbio.6b00235  [details] 
    • Groot, M. L., & Hellingwerf, K. J. (2017). Photoactive Yellow Protein: Converting Light into a Metastable Structural Change. In I. Burghardt, & S. Haacke (Eds.), Ultrafast Dynamics at the Nanoscale: Biomolecules and Supramolecular Assemblies (pp. 127-166). Singapore: Pan Stanford Publishing. [details] 



    • Angermayr, S. A., Gorchs Rovira, A., & Hellingwerf, K. J. (2015). Metabolic engineering of cyanobacteria for the synthesis of commodity products. Trends in Biotechnology, 33(6), 352-361. DOI: 10.1016/j.tibtech.2015.03.009  [details] 
    • Angermayr, S. A., van der Woude, A. D., Correddu, D., Kern, R., Hagemann, M., & Hellingwerf, K. J. (2015). Chirality Matters: Synthesis and Consumption of the d-Enantiomer of Lactic Acid by Synechocystis sp. Strain PCC6803. Applied and Environmental Microbiology, 82(4), 1295-1304. DOI: 10.1128/AEM.03379-15  [details] 
    • Savakis, P., & Hellingwerf, K. J. (2015). Engineering cyanobacteria for direct biofuel production from CO2. Current Opinion in Biotechnology, 33, 8-14. DOI: 10.1016/j.copbio.2014.09.007  [details] 
    • Schuurmans, R. M., van Alphen, P., Schuurmans, J. M., Matthijs, H. C. P., & Hellingwerf, K. J. (2015). Comparison of the Photosynthetic Yield of Cyanobacteria and Green Algae: Different Methods Give Different Answers. PLoS One, 10(9), [e0139061]. DOI: 10.1371/journal.pone.0139061  [details] 
    • van Alphen, P., & Hellingwerf, K. J. (2015). Sustained Circadian Rhythms in Continuous Light in Synechocystis sp. PCC6803 Growing in a Well-Controlled Photobioreactor. PLoS One, 10(6), e0127715. DOI: 10.1371/journal.pone.0127715  [details] 
    • van der Steen, J. B., & Hellingwerf, K. J. (2015). Activation of the General Stress Response of Bacillus subtilis by Visible Light. Photochemistry and Photobiology, 91(5), 1032-1045. DOI: 10.1111/php.12499  [details] 
    • Borirak, O., Rolfe, M. D., de Koning, L. J., Hoefsloot, H. C. J., Bekker, M., Dekker, H. L., ... Hellingwerf, K. J. (2015). Time-series analysis of the transcriptome and proteome of Escherichia coli upon glucose repression. Biochimica et Biophysica Acta. Proteins and Proteomics, 1854(10, Part A), 1269-1279. DOI: 10.1016/j.bbapap.2015.05.017  [details] 
    • Borirak, O., de Koning, L. J., van der Woude, A. D., Hoefsloot, H. C. J., Dekker, H. L., Roseboom, W., ... Hellingwerf, K. J. (2015). Quantitative proteomics analysis of an ethanol- and a lactate-producing mutant strain of Synechocystis sp. PCC6803. Biotechnology for Biofuels, 8, [111]. DOI: 10.1186/s13068-015-0294-z  [details] 
    • Ganapathy, S., Bécheau, O., Venselaar, H., Frölich, S., van der Steen, J. B., Chen, Q., ... de Grip, W. J. (2015). Modulation of spectral properties and pump activity of proteorhodopsins by retinal analogues. Biochemical Journal, 467(2), 333-343. DOI: 10.1042/BJ20141210  [details] 
    • Hammar, P., Angermayr, S. A., Sjostrom, S. L., van der Meer, J., Hellingwerf, K. J., Hudson, E. P., & Joensson, H. N. (2015). Single-cell screening of photosynthetic growth and lactate production by cyanobacteria. Biotechnology for Biofuels, 8, [193]. DOI: 10.1186/s13068-015-0380-2  [details] 
    • Nudel, C. B., & Hellingwerf, K. J. (2015). Photoreceptors in Chemotrophic Prokaryotes: The Case of Acinetobacter sps. Revisited. Photochemistry and Photobiology, 91(5), 1012-1020. DOI: 10.1111/php.12491  [details] 


    • Angermayr, S. A., van der Woude, A. D., Correddu, D., Vreugdenhil, A., Verrone, V., & Hellingwerf, K. J. (2014). Exploring metabolic engineering design principles for the photosynthetic production of lactic acid by Synechocystis sp. PCC6803. Biotechnology for Biofuels, 7, 99. DOI: 10.1186/1754-6834-7-99  [details] 
    • Schuurmans, R. M., Matthijs, H. C. P., Stal, L. J., & Hellingwerf, K. J. (2014). Cyanobacterial cellulose synthesis in the light of the photanol concept. In N. K. Sharma, A. K. Rai, & L. J. Stal (Eds.), Cyanobacteria: an economic perspective (pp. 181-196). Chichester: Wiley Blackwell. DOI: 10.1002/9781118402238.ch11  [details] 
    • Schuurmans, R. M., Schuurmans, J. M., Bekker, M., Kromkamp, J. C., Matthijs, H. C. P., & Hellingwerf, K. J. (2014). The redox potential of the plastoquinone pool of the cyanobacterium Synechocystis species strain PCC 6803 is under strict homeostatic control. Plant Physiology, 165(1), 463-475. DOI: 10.1104/pp.114.237313  [details] 
    • Bettenbrock, K., Bai, H., Ederer, M., Green, J., Hellingwerf, K. J., Holcombe, M., ... Poole, R. K. (2014). Towards a systems level understanding of the oxygen response of Escherichia coli. Advances in Microbial Physiology, 64, 65-114. DOI: 10.1016/B978-0-12-800143-1.00002-6  [details] 


    • Angermayr, S., & Hellingwerf, K. J. (2013). On the Use of Metabolic Control Analysis in the Optimization of Cyanobacterial Biosolar Cell Factories. The journal of Physical Chemistry. B, 117(38), 11169-11175. DOI: 10.1021/jp4013152  [details] 
    • Hospes, M., Hendriks, J., & Hellingwerf, K. J. (2013). Tryptophan fluorescence as a reporter for structural changes in photoactive yellow protein elicited by photo-activation. Photochemical & Photobiological Sciences, 12(3), 479-488. DOI: 10.1039/c2pp25222h  [details] 
    • Mensonides, F. I. C., Hellingwerf, K. J., Teixeira De Mattos, M. J., & Brul, S. (2013). Multiphasic adaptation of the transcriptome of Saccharomyces cerevisiae to heat stress. Food research international, 54(1), 1103-1112. DOI: 10.1016/j.foodres.2012.12.042  [details] 
    • Savakis, P. E., Angermayr, S., & Hellingwerf, K. (2013). Synthesis of 2,3-butanediol by Synechocystis sp. PCC6803 via heterologous expression of a catabolic pathway from lactic acid- and enterobacteria. Metabolic Engin., 20, 121-130. DOI: 10.1016/j.ymben.2013.09.008  [details] 
    • Sharma, P., Stagge, S., Bekker, M., Bettenbrock, K., & Hellingwerf, K. (2013). Kinase activity of ArcB from Escherichia coli is subject to regulation by both ubiquinone and demethylmenaquinone. PLoS One, 8(10), e75412. DOI: 10.1371/journal.pone.0075412  [details] 
    • van der Steen, J. B., Nakasone, Y., Hendriks, J. C., & Hellingwerf, K. J. (2013). Modeling the functioning of YtvA in the general stress response in Bacillus subtilis. Molecular BioSystems, 9, 2331-2343. DOI: 10.1039/c3mb70124g  [details] 
    • Bitrian, M., Gonzalez, R. H., Paris, G., Hellingwerf, K. J., & Nudel, C. B. (2013). Blue-light dependent inhibition of twitching motility in Acinetobacter baylyi ADP1: Additive involvement of three BLUF domain-containing proteins. Microbiology - SGM, 159(9), 1828-1841. DOI: 10.1099/mic.0.069153-0  [details] 
    • Song, S. H., Madsen, D., van der Steen, J. B., Pullman, R., Freer, L. H., Hellingwerf, K., & Larsen, D. S. (2013). Primary Photochemistry of the Dark- and Light-Adapted States of the YtvA Protein from Bacillus subtilis. Biochemistry, 52(45), 7951-7963. DOI: 10.1021/bi4012258  [details] 
    • Wijffels, R. H., Kruse, O., & Hellingwerf, K. J. (2013). Potential of industrial biotechnology with cyanobacteria and eukaryotic microalgae. Current Opinion in Biotechnology, 24(3), 405-413. DOI: 10.1016/j.copbio.2013.04.004  [details] 
    • Zhu, J., Paparelli, L., Hospes, M., Arents, J., Kennis, J. T., van Stokkum, I. H. M., ... Groot, M. L. (2013). Photoionization and Electron Radical Recombination Dynamics in Photoactive Yellow Protein Investigated by Ultrafast Spectroscopy in the Visible and Near-Infrared Spectral Region. The journal of Physical Chemistry. B, 117(38), 11042-11048. DOI: 10.1021/jp311906f  [details] 


    • Angermayr, S. A., Paszota, M., & Hellingwerf, K. J. (2012). Engineering a cyanobacterial cell factory for production of lactic acid. Applied and Environmental Microbiology, 78(19), 7098-7106. DOI: 10.1128/AEM.01587-12  [details] 
    • Hospes, M., Ippel, J. H., Boelens, R., Hellingwerf, K. J., & Hendriks, J. (2012). Binding of hydrogen-citrate to photoactive yellow protein is affected by the structural changes related to signaling state formation. The journal of Physical Chemistry. B, 116(44), 13172-13182. DOI: 10.1021/jp306891s  [details] 
    • Sharma, P., Hellingwerf, K. J., Teixeira De Mattos, M. J., & Bekker, M. (2012). Uncoupling of substrate-level phosphorylation in Escherichia coli during glucose-limited growth. Applied and Environmental Microbiology, 78(19), 6908-6913. DOI: 10.1128/AEM.01507-12  [details] 
    • Sharma, P., Teixeira De Mattos, M. J., Hellingwerf, K. J., & Bekker, M. (2012). On the function of the various quinone species in Escherichia coli. The FEBS Journal, 279, 3364-3373. DOI: 10.1111/j.1742-4658.2012.08608.x  [details] 
    • van der Steen, J. B., Ávila-Pérez, M., Knippert, D., Vreugdenhil, A., van Alphen, P., & Hellingwerf, K. J. (2012). Differentiation of function among the RsbR paralogs in the general stress response of Bacillus subtilis with regard to light perception. Journal of Bacteriology, 194(7), 1708-1716. DOI: 10.1128/JB.06705-11  [details] 
    • van Roermund, C. W. T., Ijlst, L., Majczak, W., Waterham, H. R., Folkerts, H., Wanders, R. J. A., & Hellingwerf, K. J. (2012). Peroxisomal fatty acid uptake mechanism in Saccharomyces cerevisiae. The Journal of Biological Chemistry, 287(24), 20144-20153. DOI: 10.1074/jbc.M111.332833  [details] 


    • Arents, J. C., Perez, M. A., Hendriks, J., & Hellingwerf, K. J. (2011). On the midpoint potential of the FAD chromophore in a BLUF-domain containing photoreceptor protein. FEBS Letters, 585(1), 167-172. DOI: 10.1016/j.febslet.2010.11.035  [details] 
    • Nakasone, Y., & Hellingwerf, K. J. (2011). On the binding of BODIPY-GTP by the photosensory protein YtvA from the common soil bacterium Bacillus subtilis. Photochemistry and Photobiology, 87(3), 542-547. DOI: 10.1111/j.1751-1097.2011.00919.x  [details] 
    • Rupenyan, A. B., Vreede, J., van Stokkum, I. H. M., Hospes, M., Kennis, J. T. M., Hellingwerf, K. J., & Groot, M. L. (2011). Proline 68 enhances photoisomerization yield in photoactive yellow protein. The journal of Physical Chemistry. B, 115(20), 6668-6677. DOI: 10.1021/jp112113s  [details] 
    • Sosinska, G. J., de Koning, L. J., de Groot, P. W. J., Manders, E. M. M., Dekker, H. L., Hellingwerf, K. J., ... Klis, F. M. (2011). Mass spectrometric quantification of the adaptations in the wall proteome of Candida albicans in response to ambient pH. Microbiology - SGM, 157(1), 136-146. DOI: 10.1099/mic.0.044206-0  [details] 
    • Carroll, E. C., Hospes, M., Valladares, C., Hellingwerf, K. J., & Larsen, D. S. (2011). Is the photoactive yellow protein a UV-B/blue light photoreceptor? Photochemical & Photobiological Sciences, 10(4), 464-468. DOI: 10.1039/c0pp00274g  [details] 
    • Di Donato, M., van Wilderen, L. J., van Stokkum, I. H. M., Stuart, T. C., Kennis, J. T. M., Hellingwerf, K. J., ... Groot, M. L. (2011). Proton transfer events in GFP. Physical Chemistry Chemical Physics, 13(36), 16295-16305. DOI: 10.1039/c1cp20387h  [details] 
    • Stahl, A. D., Hospes, M., Singhal, K., van Stokkum, I., van Grondelle, R., Groot, M. L., & Hellingwerf, K. J. (2011). On the involvement of single-bond rotation in the primary photochemistry of photoactive yellow protein. Biophysical Journal, 101(5), 1184-1192. DOI: 10.1016/j.bpj.2011.06.065  [details] 


    • Anemaet, I. G., Bekker, M., & Hellingwerf, K. J. (2010). Algal photosynthesis as the primary driver for a sustainable development in energy, feed, and food production. Marine Biotechnology, 12(6), 619-629. DOI: 10.1007/s10126-010-9311-1  [details] 
    • Bekker, M., Alexeeva, S., Laan, W., Sawers, G., Teixeira De Mattos, J., & Hellingwerf, K. (2010). The ArcBA two-component system of Escherichia coli is regulated by the redox state of both the ubiquinone and the menaquinone pool. Journal of Bacteriology, 192(3), 746-754. DOI: 10.1128/JB.01156-09  [details] 
    • Zakrzewska, A., Boorsma, A., ter Beek, A., Hageman, J. A., Westerhuis, J. A., Hellingwerf, K. J., ... Smits, G. J. (2010). Comparative analysis of transcriptome and fitness profiles reveals general and condition-specific cellular functions involved in adaptation to environmental change in Saccharomyces cerevisiae. Omics, 14(5), 603-614. DOI: 10.1089/omi.2010.0049  [details] 
    • Ávila-Pérez, M., van der Steen, J. B., Kort, R., & Hellingwerf, K. J. (2010). Red light activates the sigma(B)-mediated general stress response of Bacillus subtilis via the energy branch of the upstream signaling cascade. Journal of Bacteriology, 192(3), 755-762. DOI: 10.1128/JB.00826-09  [details] 
    • Metz, S., Hendriks, J., Jager, A., Hellingwerf, K., & Klug, G. (2010). In vivo effects on photosynthesis gene expression of base pair exchanges in the gene encoding the light-responsive BLUF domain of AppA in Rhodobacter sphaeroides. Photochemistry and Photobiology, 86(4), 882-889. DOI: 10.1111/j.1751-1097.2010.00749.x  [details] 


    • Angermayr, S., Hellingwerf, K., Lindblad, P., & Teixeira De Mattos, J. (2009). Energy biotechnology with cyanobacteria. Current Opinion in Biotechnology, 20(3), 257-263. DOI: 10.1016/j.copbio.2009.05.011  [details] 
    • Avila-Pérez, M., Vreede, J., Tang, Y., Bende, O., Losi, A., Gärtner, W., & Hellingwerf, K. (2009). In vivo mutational analysis of YtvA from Bacillus subtilis: Mechanism of light activation of the general stress response. The Journal of Biological Chemistry, 284(37), 24958-24964. DOI: 10.1074/jbc.M109.033316  [details] 
    • Bekker, M., de Vries, S., ter Beek, A., Hellingwerf, K. J., & Teixeira De Mattos, M. J. (2009). Respiration of Escherichia coli can be fully uncoupled via the nonelectrogenic terminal cytochrome bd-II oxidase. Journal of Bacteriology, 191(17), 5510-5517. DOI: 10.1128/JB.00562-09  [details] 
    • Hellingwerf, K. J., & Teixeira De Mattos, M. J. (2009). Alternative routes to biofuels: Light-driven biofuel formation from CO2 and water based on the ‘photanol’ approach. Journal of Biotechnology, 142(1), 87-90. DOI: 10.1016/j.jbiotec.2009.02.002  [details] 
    • Hendriks, J., & Hellingwerf, K. J. (2009). pH dependence of the photoactive yellow protein photocycle recovery reaction reveals a new late photocycle intermediate with a deprotonated chromophore. The Journal of Biological Chemistry, 284(8), 5277-5288. DOI: 10.1074/jbc.M805904200  [details] 
    • Hendriks, J., van der Horst, M. A., Chua, T. K., Ávila Pérez, M., van Wilderen, L. J., Alexandre, M. T. A., ... Hellingwerf, K. J. (2009). Photoreceptor proteins from purple bacteria. In C. N. Hunter, F. Daldal, M. C. Thurnauer, & J. T. Beatty (Eds.), The purple phototrophic bacteria (pp. 811-837). (Advances in photosynthesis and respiration; No. 28). Dordrecht: Springer. DOI: 10.1007/978-1-4020-8815-5_41  [details] 
    • Hoff, W. D., van der Horst, M. A., Nudel, B. C., & Hellingwerf, K. J. (2009). Prokaryotic phototaxis. In T. Jin, & D. Hereld (Eds.), Chemotaxis: methods and protocols (pp. 25-49). (Methods in molecular biology; No. 571). [S.l.]: Humana Press. DOI: 10.1007/978-1-60761-198-1_2  [details] 
    • Kramer, G., Sprenger, R. R., Back, J. W., Dekker, H. L., Nessen, M. A., van Maarseveen, J. H., ... de Koster, C. G. (2009). Identification and quantitation of newly synthesized proteins in Escherichia coli by enrichment of azidohomoalanine-labeled peptides with diagonal chromatography. Molecular & Cellular Proteomics, 8(7), 1599-1611. DOI: 10.1074/mcp.M800392-MCP200  [details] 
    • van der Horst, M. A., Stalcup, T. P., Kaledhonkar, S., Kumauchi, M., Hara, M., Xie, A., ... Hoff, W. D. (2009). Locked chromophore analogs reveal that photoactive yellow protein regulates biofilm formation in the deep sea bacterium Idiomarina loihiensis. Journal of the American Chemical Society, 131(47), 17443-17451. DOI: 10.1021/ja9057103  [details] 
    • Alexandre, M. T. A., Domratcheva, T., Bonetti, C., van Wilderen, L. J. G. W., van Grondelle, R., Groot, M. L., ... Kennis, J. T. M. (2009). Primary reactions of the LOV2 domain of phototropin studied with ultrafast mid-infrared spectroscopy and quantum chemistry. Biophysical Journal, 97(1), 227-237. DOI: 10.1016/j.bpj.2009.01.066  [details] 
    • Alexandre, M. T. A., van Grondelle, R., Hellingwerf, K. J., & Kennis, J. T. M. (2009). Conformational heterogeneity and propagation of structural changes in the LOV2/Jα domain from Avena sativa phototropin 1 as recorded by temperature-dependent FTIR spectroscopy. Biophysical Journal, 97(1), 238-247. DOI: 10.1016/j.bpj.2009.03.047  [details] 
    • Rupenyan, A., van Stokkum, I. H. M., Arents, J. C., van Grondelle, R., Hellingwerf, K. J., & Groot, M. L. (2009). Reaction pathways of photoexcited retinal in proteorhodopsin studied by pump-dump-probe spectroscopy. The journal of Physical Chemistry. B, 113(50), 16251-16256. DOI: 10.1021/jp9065289  [details] 
    • Rzeźnicka, I. I., Wurpel, G. W. H., Bonn, M., van der Horst, M. A., Hellingwerf, K. J., Matsunaga, S., ... Kawai, M. (2009). Observation of photoactive yellow protein anchored to a modified Au(1 1 1) surface by scanning tunneling microscopy. Chemical Physics Letters, 472(1-3), 113-117. DOI: 10.1016/j.cplett.2009.02.067  [details] 


    • Brul, S., Mensonides, F. I. C., Hellingwerf, K. J., & Teixeira De Mattos, M. J. (2008). Microbial systems biology: New frontiers open to predictive microbiology. International Journal of Food Microbiology, 128(1), 16-21. DOI: 10.1016/j.ijfoodmicro.2008.04.029  [details] 
    • Schuurmans, J. M., Rossell, S. L., van Tuijl, A., Bakker, B. M., Hellingwerf, K. J., & Teixeira De Mattos, M. J. (2008). Effect of hxk2 deletion and HAP4 overexpression on fermentative capacity in Saccharomyces cerevisiae. FEMS Yeast Research, 8(2), 195-203. DOI: 10.1111/j.1567-1364.2007.00319.x  [details] 
    • Schuurmans, J. M., Boorsma, A., Lascaris, R., Hellingwerf, K. J., & Teixeira De Mattos, M. J. (2008). Physiological and transcriptional characterization of Saccharomyces cerevisiae strains with modified expression of catabolic regulators. FEMS Yeast Research, 8(1), 26-34. DOI: 10.1111/j.1567-1364.2007.00309.x  [details] 
    • Sosinska, G. J., de Groot, P. W. J., Teixeira De Mattos, M. J., Dekker, H. L., de Koster, C. G., Hellingwerf, K. J., & Klis, F. M. (2008). Hypoxic conditions and iron restriction affect the cell-wall proteome of Candida albicans grown under vagina-simulative conditions. Microbiology - SGM, 154(2), 510-520. DOI: 10.1099/mic.0.2007/012617-0  [details] 
    • Vreede, J., Hellingwerf, K. J., & Bolhuis, P. G. (2008). Helix formation is a dynamical bottleneck in the recovery reaction of Photoactive Yellow Protein. Proteins, 72(1), 136-149. DOI: 10.1002/prot.21902  [details] 
    • Vreede, J., Hellingwerf, K. J., & Crielaard, W. (2008). TraR auto-inducer enhances protein backbone fluctuations in DNA binding domain. FEBS Letters, 582(5), 805-809. DOI: 10.1016/j.febslet.2008.01.062  [details] 
    • Alexandre, M. T. A., van Grondelle, R., Hellingwerf, K. J., Robert, B., & Kennis, J. T. M. (2008). Perturbation of the ground-state electronic structure of FMN by the conserved cysteine in phototropin LOV2 domains. Physical Chemistry Chemical Physics, 10(44), 6693-6702. DOI: 10.1039/b810040c  [details] 
    • Lee, J., Tomchick, D. R., Brautigam, C. A., Machius, M., Kort, R., Hellingwerf, K. J., & Gardner, K. H. (2008). Changes at the KinA PAS-A dimerization interface influence histidine kinase function. Biochemistry, 47(13), 4051-4064. DOI: 10.1021/bi7021156  [details] 
    • Rupenyan, A., van Stokkum, I. H. M., Arents, J. C., van Grondelle, R., Hellingwerf, K., & Groot, M. L. (2008). Characterization of the primary photochemistry of proteorhodopsin with femtosecond spectroscopy. Biophysical Journal, 94(10), 4020-4030. DOI: 10.1529/biophysj.107.121376  [details] 
    • Toh, K. C., van Stokkum, I. H. M., Hendriks, J., Alexandre, M. T. A., Arents, J. C., Avila Perez, M., ... Kennis, J. T. M. (2008). On the signaling mechanism and the absence of photoreversibility in the AppA BLUF domain. Biophysical Journal, 95(1), 312-321. DOI: 10.1529/biophysj.107.117788  [details] 


    • Savakis, P., Tan, X., Du, W., Branco dos Santos, F., Lu, X., & Hellingwerf, K. J. (2015). Photosynthetic production of glycerol by a recombinant cyanobacterium. Journal of Biotechnology, 195, 46-51. DOI: 10.1016/j.jbiotec.2014.12.015  [details] 
    • Zhu, J., Vreede, J., Hospes, M., Arents, J., Kennis, J. T. M., van Stokkum, I. H. M., ... Groot, M. L. (2015). Short Hydrogen Bonds and Negative Charge in Photoactive Yellow Protein Promote Fast Isomerization but not High Quantum Yield. The journal of Physical Chemistry. B, 119(6), 2372-2383. DOI: 10.1021/jp506785q  [details] 


    • Borirak, O., Bekker, M., & Hellingwerf, K. J. (2014). Molecular physiology of the dynamic regulation of carbon catabolite repression in Escherichia coli. Microbiology - SGM, 160(6), 1214-1223. DOI: 10.1099/mic.0.077289-0  [details] 
    • Branco dos Santos, F., Du, W., & Hellingwerf, K. J. (2014). Synechocystis: not just a plug-bug for CO2, but a green E. coli. Frontiers in Bioengineering and Biotechnology, 2, [36]. DOI: 10.3389/fbioe.2014.00036  [details] 
    • Bury, A., & Hellingwerf, K. J. (2014). On the in vivo redox state of flavin-containing photosensory receptor proteins. In S. Weber, & E. Schleicher (Eds.), Flavins and Flavoproteins: Methods and Protocols (pp. 177-190-9). (Methods in Molecular Biology; No. 1146). New York: Humana Press. DOI: 10.1007/978-1-4939-0452-5_9  [details] 
    • Mensonides, F. I. C., Brul, S., Hellingwerf, K. J., Bakker, B. M., & Teixeira De Mattos, M. J. (2014). A kinetic model of catabolic adaptation and protein reprofiling in Saccharomyces cerevisiae during temperature shifts. The FEBS Journal, 281(3), 825-841. DOI: 10.1111/febs.12649  [details] 
    • van Beilen, J. W. A., Teixeira De Mattos, M. J., Hellingwerf, K. J., & Brul, S. (2014). Distinct Effects of Sorbic Acid and Acetic Acid on the Electrophysiology and Metabolism of Bacillus subtilis. Applied and Environmental Microbiology, 80(19), 5918-5926. DOI: 10.1128/AEM.01391-14  [details] 
    • van der Woude, A. D., Angermayr, S. A., Puthan Veetil, V., Osnato, A., & Hellingwerf, K. J. (2014). Carbon sink removal: Increased photosynthetic production of lactic acid by Synechocystis sp. PCC6803 in a glycogen storage mutant. Journal of Biotechnology, 184, 100-102. DOI: 10.1016/j.jbiotec.2014.04.029  [details] 


    • Hendriks, J., Hospes, M., & Hellingwerf, K. J. (2011). Photoactive yellow protein, the prototype Xanthopsin. In H. W. Lenci, F. (Ed.), CRC Handbook of Organic Photochemistry and Photobiology (pp. 1137-1160). CRC Press. DOI: 10.1201/9780203495902.ch123  [details] 


    • Hellingwerf, K. J., van Lieshout, T., Koblens, P., van Grondelle, W., & van Alphen, P. (2016). Arrangement of a photobioreactor or a microbiological reactor


    • Borirak, O., Bekker, M., Rolfe, M. D., Dekker, H. L., de Jong, L., de Koster, C. G., ... Hellingwerf, K. J. (2013). Dynamic changes of the Escherichia coli transcriptome and proteome exerted by glucose repression. The FASEB Journal, 27(1 Supplement), [lb136]. [details] 


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