I am heading the genome technology and bioinformatics expertise centre of the FNWI named "MAD:Dutch Genomics Service & Support Provider)" and the research group "RNA Biology and Applied Bioinformatics (RB&AB)" . The group consists of about 10 multidiciplinary experts in the fields of microarray technology, next-generation sequencing technology, bioinformatics and informatics. For detailed information see our websites: www.dutchgenomics.nl and www.RNAbiology.nl.
Service: The MAD is a genomics technology centre with short-read Illumina NextSeq next-generation sequencing and ultra-long read Oxford Nanopor MinIon platforms. We operate as platform for R&D, as well as service center. As Genomics Service Provider, we offer tailor-made services in the field of gene expression, DNA analysis and related bioinformatics. Our expertise includes:
The MAD comprises a wet-lab and a dry-lab. The wet-lab takes care of all genomics technology services. The dry-lab acts as a bioinformatics support group for all genomics data analyses. Research: The MAD acts not only as a service provider, but also as a partner in scientific projects. These projects range from toxicogenomics (genomic analysis and in vivo imaging of stress in aging-related disease funded by IOP -EMC, LUMC, LACDR, RIVM), food safety (Unilever) and mechanistic studies (e.g. Biofilm -ACTA-) and biomarkers (RIVM, plant-breeding companies). The MAD is always in for collaboration or participation in projects concerning genomics technology or analysis. If you need an expert next-generations sequencing or bioinformatics partner for your project, please contact me (t.m.breit -at- uva.nl).
With respect to RB&AB: RNA is increasingly recognized to have more functions than just being a “messenger” between DNA and proteins. New forms of RNA and RNA functions are continuously discovered, such as small regulatory microRNAs. Our research aims to understand transcriptome dynamics plus the role of RNA as a carrier of genetic information. As such, we have a keen interest in so-called ‘non-coding RNA’, ‘maternal RNA’ as well as ‘cell-free RNA’. We apply an multidisciplinary omics approach that includes a large bioinformatics component. The RNA Biology & Applied Bioinformatics research group (RB&AB) is part of the University of Amsterdam.
Research lines RNA Biology: