Dr. C.P. (Carlos) Fitzsimons
Faculteit der Natuurwetenschappen, Wiskunde en Informatica
Swammerdam Institute for Life Sciences
Bezoekadres
- Science Park 904
- Kamernummer: C3.271
Postadres
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Postbus 94246
1090 GE Amsterdam
Contactgegevens
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Publicaties
2024
Bielefeld, P., Martirosyan, A., Martín-Suárez, S., Apresyan, A., Meerhoff, G. F., Pestana, F., Poovathingal, S., Reijner, N., Koning, W., Clement, R. A., Van der Veen, I., Toledo, E. M., Polzer, O., Durá, I., Hovhannisyan, S., Nilges, B. S., Bogdoll, A., Kashikar, N. D., Lucassen, P. J., ... Fitzsimons, C. P. (2024). Traumatic brain injury promotes neurogenesis at the cost of astrogliogenesis in the adult hippocampus of male mice. Nature Communications, 15, Article 5222. https://doi.org/10.1038/s41467-024-49299-6 [details]- Dohm-Hansen, S., English, J. A., Lavelle, A., Fitzsimons, C. P., Lucassen, P. J., & Nolan, Y. M. (2024). The 'middle-aging' brain. Trends in Neurosciences, 47(4), 259-272. https://doi.org/10.1016/j.tins.2024.02.001 [details]
- Rodrigues, R. S., Moreira, J. B., Mateus, J. M., Barateiro, A., Paulo, S. L., Vaz, S. H., Lourenço, D. M., Ribeiro, F. F., Soares, R., Loureiro-Campos, E., Bielefeld, P., Sebastião, A. M., Fernandes, A., Pinto, L., Fitzsimons, C. P., & Xapelli, S. (2024). Cannabinoid type 2 receptor inhibition enhances the antidepressant and proneurogenic effects of physical exercise after chronic stress. Translational Psychiatry, 14(1), Article 170. https://doi.org/10.1038/s41398-024-02877-0 [details]
2023
- Gasperini, C., Tuntevski, K., Beatini, S., Pelizzoli, R., Lo Van, A., Mangoni, D., Cossu, R. M., Pascarella, G., Bianchini, P., Bielefeld, P., Scarpato, M., Pons-Espinal, M., Sanges, R., Diaspro, A., Fitzsimons, C. P., Carninci, P., Gustincich, S., & De Pietri Tonelli, D. (2023). Piwil2 (Mili) sustains neurogenesis and prevents cellular senescence in the postnatal hippocampus. EMBO Reports, 24(2), Article e53801. Advance online publication. https://doi.org/10.15252/embr.202153801 [details]
- Granja-Galeano, G., Dominguez-Rubio, A. P., Zappia, C. D., Wolfson, M., Sanz-Blasco, S., Aisemberg, J., Zorrilla-Zubilete, M., Fernandez, N., Franchi, A., Fitzsimons, C. P., & Monczor, F. (2023). CB1 receptor expression and signaling are required for dexamethasone-induced aversive memory consolidation. Neuropharmacology, 239, Article 109674. Advance online publication. https://doi.org/10.1016/j.neuropharm.2023.109674 [details]
- Salta, E., Lazarov, O., Fitzsimons, C. P., Tanzi, R., Lucassen, P. J., & Choi, S. H. (2023). Adult hippocampal neurogenesis in Alzheimer's disease: A roadmap to clinical relevance. Cell Stem Cell, 30(2), 120-136. https://doi.org/10.1016/j.stem.2023.01.002 [details]
- Tosoni, G., Ayyildiz, D., Bryois, J., Macnair, W., Fitzsimons, C. P., Lucassen, P. J., & Salta, E. (2023). Mapping human adult hippocampal neurogenesis with single-cell transcriptomics: Reconciling controversy or fueling the debate? Neuron, 111(11), 1714-1731. https://doi.org/10.1016/j.neuron.2023.03.010 [details]
2022
- Penning, A., Tosoni, G., Abiega, O., Bielefeld, P., Gasperini, C., De Pietri Tonelli, D., Fitzsimons, C. P., & Salta, E. (2022). Adult Neural Stem Cell Regulation by Small Non-coding RNAs: Physiological Significance and Pathological Implications. Frontiers in Cellular Neuroscience, 15, Article 781434. https://doi.org/10.3389/fncel.2021.781434 [details]
- Sanguino-Gómez, J., Buurstede, J. C., Abiega, O., Fitzsimons, C. P., Lucassen, P. J., Eggen, B. J. L., Lesuis, S. L., Meijer, O. C., & Krugers, H. J. (2022). An emerging role for microglia in stress-effects on memory. European Journal of Neuroscience, 55(9-10), 2491-2518. Advance online publication. https://doi.org/10.1111/ejn.15188 [details]
- Yshii, L., Pasciuto, E., Bielefeld, P., Mascali, L., Lemaitre, P., Marino, M., Dooley, J., Kouser, L., Verschoren, S., Lagou, V., Kemps, H., Gervois, P., de Boer, A., Burton, O. T., Wahis, J., Verhaert, J., Tareen, S. H. K., Roca, C. P., Singh, K., ... Liston, A. (2022). Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation. Nature Immunology, 23(6), 878-891. https://doi.org/10.1038/s41590-022-01208-z [details]
2021
- Bielefeld, P., Abbink, M. R., Davidson, A. R., Reijner, N., Abiega, O., Lucassen, P. J., Korosi, A., & Fitzsimons, C. P. (2021). Early life stress decreases cell proliferation and the number of putative adult neural stem cells in the adult hypothalamus. Stress - the International Journal on the Biology of Stress, 24(2), 189-195. Advance online publication. https://doi.org/10.1080/10253890.2021.1879787 [details]
- Homberg, J. R., Adan, R. A. H., Alenina, N., Asiminas, A., Bader, M., Beckers, T., Begg, D. P., Blokland, A., Burger, M. E., van Dijk, G., Eisel, U. L. M., Elgersma, Y., Englitz, B., Fernandez-Ruiz, A., Fitzsimons, C. P., van Dam, A.-M., Gass, P., Grandjean, J., Havekes, R., ... Genzel, L. (2021). The continued need for animals to advance brain research. Neuron, 109(15), 2374-2379. https://doi.org/10.1016/j.neuron.2021.07.015 [details]
- Lesuis, S. L., Brosens, N., Immerzeel, N., van der Loo, R. J., Mitrić, M., Bielefeld, P., Fitzsimons, C. P., Lucassen, P. J., Kushner, S. A., van den Oever, M. C., & Krugers, H. J. (2021). Glucocorticoids Promote Fear Generalization by Increasing the Size of a Dentate Gyrus Engram Cell Population. Biological Psychiatry, 90(7), 494-504. Advance online publication. https://doi.org/10.1016/j.biopsych.2021.04.010 [details]
- Sharif, A., Fitzsimons, C. P., & Lucassen, P. J. (2021). Neurogenesis in the adult hypothalamus: A distinct form of structural plasticity involved in metabolic and circadian regulation, with potential relevance for human pathophysiology. In D. F. Swaab, F. Kreier, P. J. Lucassen, A. Salehi, & R. M. Buijs (Eds.), The Human Hypothalamus: Anterior Region (pp. 125-140). (Handbook of Clinical Neurology; Vol. 179). Elsevier. https://doi.org/10.1016/B978-0-12-819975-6.00006-6 [details]
- Zappia, C. D., Torralba-Agu, V., Echeverria, E., Fitzsimons, C. P., Fernández, N., & Monczor, F. (2021). Antihistamines Potentiate Dexamethasone Anti-Inflammatory Effects. Impact on Glucocorticoid Receptor-Mediated Expression of Inflammation-Related Genes. Cells, 10(11), Article 3026. https://doi.org/10.3390/cells10113026 [details]
2020
- Genzel, L., Adan, R., Berns, A., van den Beucken, J. J. J. P., Blokland, A., Boddeke, E. H. W. G. M., Bogers, W. M., Bontrop, R., Bulthuis, R., Bousema, T., Clevers, H., Coenen, T. C. J. J., van Dam, A-M., Deen, P. M. T., van Dijk, K. W., Eggen, B. J. L., Elgersma, Y., Erdogan, I., Englitz, B., ... Homberg, J. R. (2020). How the COVID-19 pandemic highlights the necessity of animal research: correction. Current Biology, 30(21), 4328. https://doi.org/10.1016/j.cub.2020.10.033
- Genzel, L., Adan, R., Berns, A., van den Beucken, J. J. J. P., Blokland, A., Boddeke, E. H. W. G. M., Bogers, W. M., Bontrop, R., Bulthuis, R., Bousema, T., Clevers, H., Coenen, T. C. J. J., van Dam, A.-M., Deen, P. M. T., van Dijk, K. W., Eggen, B. J. L., Elgersma, Y., Erdogan, I., Englitz, B., ... Homberg, J. R. (2020). How the COVID-19 pandemic highlights the necessity of animal research. Current Biology, 30(18), R1014-R1018. https://doi.org/10.1016/j.cub.2020.08.030 [details]
- Gu, Y., Ge, S., & Fitzsimons, C. P. (2020). Editorial: Functional Adult Neurogenesis. Frontiers in Neuroscience, 14, Article 885. https://doi.org/10.3389/fnins.2020.00885 [details]
- Lucassen, P. J., Fitzsimons, C. P., Salta, E., & Maletic-Savatic, M. (2020). Adult neurogenesis, human after all (again): Classic, optimized, and future approaches. Behavioural Brain Research, 381, Article 112458. https://doi.org/10.1016/j.bbr.2019.112458 [details]
- Schouten, M., Bielefeld, P., Garcia-Corzo, L., Passchier, E. M. J., Gradari, S., Jungenitz, T., Pons-Espinal, M., Gebara, E., Martín-Suárez, S., Lucassen, P. J., De Vries, H. E., Trejo, J. L., Schwarzacher, S. W., De Pietri Tonelli, D., Toni, N., Mira, H., Encinas, J. M., & Fitzsimons, C. P. (2020). Circadian glucocorticoid oscillations preserve a population of adult hippocampal neural stem cells in the aging brain. Molecular Psychiatry, 25(7), 1382-1405. Advance online publication. https://doi.org/10.1038/s41380-019-0440-2 [details]
- Xapelli, S., Diógenes, M., Crunelli, V., Fitzsimons, C. P., & Vaz, S. (2020). Editorial: Glial and Neural Stem Cells as New Therapeutic Targets for Neurodegenerative Disorders. Frontiers in Cellular Neuroscience, 4, Article 71. https://doi.org/10.3389/fncel.2020.00071 [details]
2019
- Bielefeld, P., Durá, I., Danielewicz, J., Lucassen, P. J., Baekelandt, V., Abrous, D. N., Encinas, J. M., & Fitzsimons, C. P. (2019). Insult-induced aberrant hippocampal neurogenesis: Functional consequences and possible therapeutic strategies. Behavioural Brain Research, 372, Article 112032. https://doi.org/10.1016/j.bbr.2019.112032 [details]
- Bielefeld, P., Schouten, M., Meijer, G. M., Breuk, M. J., Geijtenbeek, K., Karayel, S., Tiaglik, A., Vuuregge, A. H., Willems, R. A. L., Witkamp, D., Lucassen, P. J., Encinas, J. M., & Fitzsimons, C. P. (2019). Co-administration of Anti microRNA-124 and -137 Oligonucleotides Prevents Hippocampal Neural Stem Cell Loss Upon Non-convulsive Seizures. Frontiers in Molecular Neuroscience, 12, Article 31. https://doi.org/10.3389/fnmol.2019.00031 [details]
- Monczor, F., Chatzopoulou, A., Zappia, C. D., Houtman, R., Meijer, O. C., & Fitzsimons, C. P. (2019). A Model of Glucocorticoid Receptor Interaction With Coregulators Predicts Transcriptional Regulation of Target Genes. Frontiers in Pharmacology, 10, Article 214. https://doi.org/10.3389/fphar.2019.00214 [details]
- Zappia, C. D., Soto, A., Granja-Galeano, G., Fenoy, I., Fernandez, N., Davio, C. A., Shayo, C., Fitzsimons, C. P., Goldman, A., & Monczor, F. (2019). Azelastine potentiates antiasthmatic dexamethasone effect on a murine asthma model. Pharmacology research & perspectives, 7(6), e00531. https://doi.org/10.1002/prp2.531 [details]
2018
- van Olst, L., Bielefeld, P., Fitzsimons, C. P., de Vries, H. E., & Schouten, M. (2018). Glucocorticoid-mediated modulation of morphological changes associated with aging in microglia. Aging Cell, 17(4), Article e12790. Advance online publication. https://doi.org/10.1111/acel.12790 [details]
2017
- Bielefeld, P., Mooney, C., Henshall, D. C., & Fitzsimons, C. P. (2017). miRNA-Mediated Regulation of Adult Hippocampal Neurogenesis; Implications for Epilepsy. Brain Plasticity, 3(1), 43-59. Advance online publication. https://doi.org/10.3233/BPL-160036 [details]
- Bielefeld, P., Pustjens, B., Schouten, M., & Fitzsimons, C. P. (2017). MicroRNA-Mediated Regulation of Adult Hippocampal Neurogenesis: Implications for Hippocampus-dependent Cognition and Related Disorders? In D. De Pietri Tonelli (Ed.), Essentials of Noncoding RNA in Neuroscience: Ontogenetics, Plasticity of the Vertebrate Brain (pp. 155-176). Academic Press. https://doi.org/10.1016/B978-0-12-804402-5.00009-1 [details]
- Bielefeld, P., Schouten, M., Lucassen, P. J., & Fitzsimons, C. P. (2017). Transcription factor oscillations in neural stem cells: implications for accurate control of gene expression. Neurogenesis, 4(1), Article e1262934. https://doi.org/10.1080/23262133.2016.1262934 [details]
- Bielefeld, P., Sierra, A., Encinas, J. M., Maletic-Savatic, M., Anderson, A., & Fitzsimons, C. P. (2017). A Standardized Protocol for Stereotaxic Intrahippocampal Administration of Kainic Acid Combined with Electroencephalographic Seizure Monitoring in Mice. Frontiers in Neuroscience, 11, Article 160. https://doi.org/10.3389/fnins.2017.00160 [details]
- De Luca, G. M. R., Desclos, E., Breedijk, R. M. P., Dolz-Edo, L., Smits, G. J., Nahidiazar, L., Bielefeld, P., Picavet, L., Fitzsimons, C. P., Hoebe, R., & Manders, E. M. M. (2017). Configurations of the Re-scan Confocal Microscope (RCM) for biomedical applications. Journal of Microscopy, 266(2), 166-177. Advance online publication. https://doi.org/10.1111/jmi.12526 [details]
- Encinas, J. M., & Fitzsimons, C. P. (2017). Gene regulation in adult neural stem cells: Current challenges and possible applications. Advanced drug delivery reviews, 120, 118-132. https://doi.org/10.1016/j.addr.2017.07.016 [details]
2016
- Fitzsimons, C. P., Herbert, J., Schouten, M., Meijer, O. C., Lucassen, P. J., & Lightman, S. (2016). Circadian and ultradian glucocorticoid rhythmicity: Implications for the effects of glucocorticoids on neural stem cells and adult hippocampal neurogenesis. Frontiers in Neuroendocrinology, 41, 44-58. Advance online publication. https://doi.org/10.1016/j.yfrne.2016.05.001 [details]
- Lucassen, P. J., Oomen, C. A., Naninck, E. F. G., Fitzsimons, C. P., van Dam, A-M., Czeh, B., & Korosi, A. (2016). Regulation of adult neurogenesis and plasticity by (early) stress, glucocorticoids and inflammation. In F. H. Gage, G. Kempermann, & H. Song (Eds.), Neurogenesis: a subject collection from Cold Spring Harbor Perspectives in Biology (pp. 255-270). (Cold Spring Harbor perspectives in biology). Cold Spring Harbor Laboratory Press. https://doi.org/10.1101/cshperspect.a021303 [details]
- Lucassen, P. J., Oomen, C. A., Schouten, M., Encinas, J. M., & Fitzsimons, C. P. (2016). Adult Neurogenesis, Chronic Stress and Depression. In J. J. Canales (Ed.), Adult neurogenesis in the hippocampus: health, psychopathology, and brain disease (pp. 177-206). Academic Press. https://doi.org/10.1016/B978-0-12-801977-1.00008-8 [details]
- Schouten, M., Bielefeld, P., Fratantoni, S. A., Hubens, C. J., Piersma, S. R., Pham, T. V., Voskuyl, R. A., Lucassen, P. J., Jimenez, C. R., & Fitzsimons, C. P. (2016). Multi-omics profile of the mouse dentate gyrus after kainic acid induced status epilepticus. Scientific Data, 3, Article 160068. https://doi.org/10.1038/sdata.2016.68 [details]
- Schouten, M., Papaloukas, N., Bielefeld, P., Fratantoni, S. A., & Fitzsimons, C. P. (2016). Epigenetic mechanisms regulating the transition from embryonic stem cells towards a differentiated neural progeny. In G. Steinhoff (Ed.), Regenerative Medicine - from Protocol to Patient - 1: Biology of Tissue Regeneration (3rd ed., pp. 151-173). Springer. https://doi.org/10.1007/978-3-319-27583-3_5 [details]
2015
- Lucassen, P. J., Oomen, C. A., Naninck, E. F. G., Fitzsimons, C. P., van Dam, A-M., Czeh, B., & Korosi, A. (2015). Regulation of Adult Neurogenesis and Plasticity by (Early) Stress, Glucocorticoids, and Inflammation. Cold Spring Harbor Perspectives in Biology, 7(9), Article a021303. https://doi.org/10.1101/cshperspect.a021303 [details]
- Schouten, M., Fratantoni, S. A., Hubens, C. J., Piersma, S. R., Pham, T. V., Bielefeld, P., Voskuyl, R. A., Lucassen, P. J., Jimenez, C. R., & Fitzsimons, C. P. (2015). MicroRNA-124 and -137 cooperativity controls caspase-3 activity through BCL2L13 in hippocampal neural stem cells. Scientific Reports, 5, Article 12448. https://doi.org/10.1038/srep12448 [details]
- Zappia, C. D., Granja-Galeano, G., Fernández, N., Shayo, C., Davio, C., Fitzsimons, C. P., & Monczor, F. (2015). Effects of histamine H1 receptor signaling on glucocorticoid receptor activity. Role of canonical and non-canonical pathways. Scientific Reports, 5, Article 17476. https://doi.org/10.1038/srep17476 [details]
2014
- Bielefeld, P., van Vliet, E. A., Gorter, J. A., Lucassen, P. J., & Fitzsimons, C. P. (2014). Different subsets of newborn granule cells: a possible role in epileptogenesis? European Journal of Neuroscience, 39(1), 1-11. https://doi.org/10.1111/ejn.12387 [details]
- Fitzsimons, C. P., van Bodegraven, E., Schouten, M., Lardenoije, R., Kompotis, K., Kenis, G., van den Hurk, M., Boks, M. P., Biojone, C., Joca, S., Steinbusch, H. W., Lunnon, K., Mastroeni, D. F., Mill, J., Lucassen, P. J., Coleman, P. D., Van den Hove, D. L., & Rutten, B. P. F. (2014). Epigenetic regulation of adult neural stem cells: implications for Alzheimer's disease. Molecular Neurodegeneration, 9, 25. https://doi.org/10.1186/1750-1326-9-25 [details]
- Jung, T. I., Vogiatzian, F., Har-Shemesh, O., Fitzsimons, C. P., & Quax, R. (2014). Applying Information Theory to Neuronal Networks: From Theory to Experiments. Entropy, 16(11), 5721-5737. https://doi.org/10.3390/e16115721 [details]
- Schouten, M., De Luca, G. M. R., Alatriste González, D. K., de Jong, B. E., Timmermans, W., Xiong, H., Krugers, H., Manders, E. M. M., & Fitzsimons, C. P. (2014). Imaging dendritic spines of rat primary hippocampal neurons using structured illumination microscopy. Journal of Visualized Experiments, 87, Article e51276. https://doi.org/10.3791/51276 [details]
- Van den Hove, D. L., Kompotis, K., Lardenoije, R., Kenis, G., Mill, J., Steinbusch, H. W., Lesch, K. P., Fitzsimons, C. P., De Strooper, B., & Rutten, B. P. F. (2014). Epigenetically regulated microRNAs in Alzheimer's disease. Neurobiology of Aging, 35(4), 731-745. https://doi.org/10.1016/j.neurobiolaging.2013.10.082 [details]
2013
- Fitzsimons, C. P., van Hooijdonk, L. W. A., Schouten, M., Zalachoras, I., Brinks, V., Zheng, T., Schouten, T. G., Saaltink, D. J., Dijkmans, T., Steindler, D. A., Verhaagen, J., Verbeek, F. J., Lucassen, P. J., de Kloet, E. R., Meijer, O. C., Karst, H., Joels, M., Oitzl, M. S., & Vreugdenhil, E. (2013). Knockdown of the glucocorticoid receptor alters functional integration of newborn neurons in the adult hippocampus and impairs fear-motivated behavior. Molecular Psychiatry, 18(9), 993-1005. Advance online publication. https://doi.org/10.1038/mp.2012.123 [details]
- Lucassen, P. J., Fitzsimons, C. P., Korosi, A., Joels, M., Belzung, C., & Abrous, D. N. (2013). Stressing new neurons into depression? Molecular Psychiatry, 18(4), 396-397. Advance online publication. https://doi.org/10.1038/mp.2012.39 [details]
- Lucassen, P. J., Naninck, E. F. G., van Goudoever, J. B., Fitzsimons, C., Joels, M., & Korosi, A. (2013). Perinatal programming of adult hippocampal structure and function; emerging roles of stress, nutrition and epigenetics. Trends in Neurosciences, 36(11), 621-631. https://doi.org/10.1016/j.tins.2013.08.002 [details]
- Monczor, F., Fernandez, N., Fitzsimons, C. P., Shayo, C., & Davio, C. (2013). Antihistaminergics and inverse agonism: potential therapeutic applications. European Journal of Pharmacology, 715(1-3), 26-32. Advance online publication. https://doi.org/10.1016/j.ejphar.2013.06.027 [details]
- Schouten, M., Aschrafi, A., Bielefeld, P., Doxakis, E., & Fitzsimons, C. P. (2013). microRNAs and the regulation of neuronal plasticity under stress conditions. Neuroscience, 241, 188-205. https://doi.org/10.1016/j.neuroscience.2013.02.065 [details]
- Verissimo, C. S., Elands, R., Cheng, S., Saaltink, D. J., ter Horst, J. P., Alme, M. N., Pont, C., van de Water, B., Håvik, B., Fitzsimons, C. P., & Vreugdenhil, E. (2013). Silencing of Doublecortin-Like (DCL) Results in Decreased Mitochondrial Activity and Delayed Neuroblastoma Tumor Growth. PLoS ONE, 8(9), e75752. Article e75752. https://doi.org/10.1371/journal.pone.0075752 [details]
2012
- Fitzsimons, C. P., Vreugdenhil, E., & Lucassen, P. J. (2012). Inhibition of Adult Neurogenesis through ERK5 knockdown Impairs Complex Hippocampus-dependent Spatial Memory Tasks. Future Neurology, 7(5), 531-535. https://doi.org/10.2217/fnl.12.55 [details]
- Korosi, A., Naninck, E. F. G., Oomen, C. A., Schouten, M., Krugers, H., Fitzsimons, C., & Lucassen, P. J. (2012). Early-life stress mediated modulation of adult neurogenesis and behavior. Behavioural Brain Research, 227(2), 400-409. Advance online publication. https://doi.org/10.1016/j.bbr.2011.07.037 [details]
- Schouten, M., Buijink, M. R., Lucassen, P. J., & Fitzsimons, C. P. (2012). New neurons in aging brains: molecular control by small non-coding RNAs. Frontiers in Neuroscience, 6, Article 25. https://doi.org/10.3389/2Ffnins.2012.00025 [details]
- Verissimo, C. S., Cheng, S., Puigvert, J. C., Qin, Y., Vroon, A., van Deutekom, J., Price, L. S., Danen, E. H. J., van de Water, B., Fitzsimons, C. P., & Vreugdenhil, E. (2012). Combining doublecortin-like kinase silencing and vinca alkaloids results in a synergistic apoptotic effect in neuroblastoma cells. The Journal of Pharmacology and experimental Therapeutics, 342(1), 119-130. Advance online publication. https://doi.org/10.1124/jpet.111.188813 [details]
2011
- Eendebak, R. J. A. H., Lucassen, P. J., & Fitzsimons, C. P. (2011). Nuclear receptors and microRNAs: who regulates the regulators in neural stem cells? FEBS Letters, 585(5), 717-22. https://doi.org/10.1016/j.febslet.2011.01.039 [details]
- Lucassen, P. J., Fitzsimons, C. P., Vreugdenhil, E., Hu, P., Oomen, C., Revsin, Y., Joëls, M., & de Kloet, E. R. (2011). Regulation of structural plasticity and neurogenesis during stress and diabetes; protective effects of glucocorticoid receptor antagonists. In A. G. Gravanis, & S. H. Mellon (Eds.), Hormones in neurodegeneration, neuroprotection, and neurogenesis (pp. 103-120). Wiley-VCH. https://doi.org/10.1002/9783527633968.ch6 [details]
- Verissimo, C. S., Molenaar, J. J., Fitzsimons, C. P., & Vreugdenhil, E. (2011). Neuroblastoma therapy: what is in the pipeline? Endocrine related cancer, 18, R213-R231. https://doi.org/10.1530/ERC-11-0251 [details]
2007
- Vreugdenhil, E., Kolk, S. M., Boekhoorn, K., Fitzsimons, C. P., Schaaf, M., Schouten, T., Sarabdjitsingh, A., Sibug, R., & Lucassen, P. J. (2007). Doublecortin-like, a microtubule-associated protein expressed in radial glia, is crucial for neuronal precursor division and radial process stability. European Journal of Neuroscience, 25(3), 635-648. https://doi.org/10.1111/j.1460-9568.2007.05318.x [details]
2019
- Lucassen, P. J., Lesuis, S. L., Hoeijmakers, L., Yam, K. Y., Fitzsimons, C. P., Korosi, A., & Krugers, H. (2019). Brain plasticity in relation to (early life) stress, nutrition and dementia. Journal of Neural Transmission, 126(11), 1561-1562.
- Lucassen, P. J., van Dam, A-M., Kandel, P., Bielefeld, P., Korosi, A., Fitzsimons, C. P., & Maletic-Savatic, M. (2019). The orphan nuclear receptor TLX: an emerging master regulator of crosstalk between microglia and neural precursor cells. Neuronal Signaling , 3(2), Article NS20180208. https://doi.org/10.1042/NS20180208 [details]
2014
- Kuipers, S. D., Bramham, C. R., Cameron, H. A., Fitzsimons, C. P., Korosi, A., & Lucassen, P. J. (2014). Environmental Control of Adult Neurogenesis: From Hippocampal Homeostasis to Behavior and Disease. Neural Plasticity, 2014, 808643. https://doi.org/10.1155/2014/808643 [details]
Prijs / subsidie
- Ilie, I., Reek, J. & Fitzsimons, C. (2024). MMD hub grant: Digital development of drug nanocarriers for Alzheimer’s disease. https://hims.uva.nl/shared/faculteiten/en/faculteit-der-natuurwetenschappen-wiskunde-en-informatica/news/2024/07/nine-research-projects-chos…
- Fitzsimons, C. P. (2014). Top Paper Prize 2014. http://enp2014.azuleon.org/awards.php
- Fitzsimons, C. (2012). Certificate for Learning and teaching in higher education program.
- Fitzsimons, C. P. (2012). Finalist.
Lidmaatschap / relevante positie
- Fitzsimons, C. P. (2016-). Member of the Evaluation Commission of the ALW Open Programme - NWO., ALW-NWO.
- Fitzsimons, C. P. (2015). Member of the Evaluation Commission of the ALW Open Programme, NWO, The Hague.
- Fitzsimons, C. P. (2015). Member of the Working Group on Governance Innovation, enforced by the Dean of the Faculty of Sciences, University of Amsterdam.
- Fitzsimons, C. P. (2015). Member of the Joint Exam Commission Bachelor and Master Programs in Biomedical Sciences, Faculty of Sciences, University of Amsterdam.
- Fitzsimons, C. P. (2014). Member of the Exam commission Master Program Biomedical Sciences, Faculty of Sciences, University of Amsterdam.
Mediaoptreden
- Fitzsimons, C. P. (01-01-2015). De invloed van stress op de ziekte van Alzheimer. [Print]. De invloed van stress op de ziekte van Alzheimer.. https://www.alzheimer.nl/nieuws-en-voorlichting/alzheimer-actueel
- Fitzsimons, C. P. (01-01-2015). De invloed van stress op de ziekte van Alzheimer. [Print]. De invloed van stress op de ziekte van Alzheimer.. https://www.alzheimer.nl/nieuws-en-voorlichting/alzheimer-actueel
Tijdschriftredactie
- Fitzsimons, C. (editor) (2020-2025). Frontiers in Cellular Neuroscience (Journal).
- Fitzsimons, C. (editor) (2019-2024). Frontiers in Molecular Neuroscience (Journal).
- Fitzsimons, C. P. (editor) (2016). Scientific Reports (Journal).
- Fitzsimons, C. P. (editor) (2015). F1000Research (Journal). http://f1000research.com/articles/3-169/v1
- Fitzsimons, C. P. (editor) (2015). Frontiers in Neuroscience (Journal).
- Fitzsimons, C. P. (editor) (2014). Neural Plasticity (Journal). http://www.hindawi.com/journals/np/si/526861
Spreker
- Fitzsimons, C. (speaker) (5-7-2021). Glucocorticoid circadian oscillations control the architecture of the adult hippocampal neurogenic niche in the aging brain, European Meeting on Glial Cells in Health and Disease.
- Fitzsimons, C. (speaker) (28-3-2021). Modulation of the glucocorticoid system to regulate neural stem cells and microglia and promote neurogenesis in the aging brain., INSERM, U1215 NeuroCentre Magendie, 33000 Bordeaux, France; University of Bordeaux, 33000 Bordeaux, France..
- Fitzsimons, C. (speaker) (16-6-2019). Circadian glucocorticoid oscillations preserve a population of neural stem cells in the aging brain., invited lecture at the Eurogenesis Meeting, Bordeaux, France.
- Fitzsimons, C. (speaker) (15-8-2018). Circadian glucocorticoid oscillations preserve a population of neural stem cells in the aging brain., INSERM, U1215 NeuroCentre Magendie, 33000 Bordeaux, France; University of Bordeaux, 33000 Bordeaux, France..
- Fitzsimons, C. (speaker) (2-5-2018). Circadian glucocorticoid oscillations control dendritic development and dendritic spine turnover in hippocampal newborn neurons., Adult Neurogenesis Conference , Dresden.
- Fitzsimons, C. (speaker) (22-3-2018). Circadian glucocorticoid oscillations preserve a population of neural stem cells in the aging brain., Achucarro Basque Center for NeuroscienceZamudio, Spain; Ikerbasque FoundationBilbao, Spain; University of the Basque Country (UPV/EHU)Leioa, Spain..
- Fitzsimons, C. (speaker) (15-3-2018). Circadian glucocorticoid oscillations preserve a population of neural stem cells in the aging brain., Undoing Aging, Berlin.
- Fitzsimons, C. (speaker) (15-1-2018). Circadian rhythms, hormones, metabolism and brain function., Biomedical Sciences Symposium, Leiden.
- Fitzsimons, C. P. (invited speaker) (24-9-2017). From stem to spine Gene regulation in adult neural stem cells., Instituto de Farmacologia e Neurociências Faculdade de Medicina da Universidade de Lisboa.
- Fitzsimons, C. P. (invited speaker) (23-3-2017). Two is better than one. Cooperative gene regulation by microRNAs in neural stem cells, 12th Gottingen Meeting of the German Neuroscience Society, Goettingen. https://www.nwg-goettingen.de/2017/upload/file/Program_Goettingen2017_small.pdf
- Fitzsimons, C. P. (invited speaker) (15-3-2017). microRNAs controls NSC fate in the dentate gyrus., Kick off meeting REACT NSC - ERA-NET NEURON , Bordeaux . https://neurocentre-magendie.fr/index.php?lang=en
- Fitzsimons, C. P. (invited speaker) (30-11-2016). Glucocorticoid hormones preserve a population of adult hippocampal neural stem cells in the aging brain., Nuclear Receptor Research Network meeting, Amsterdam.
- Fitzsimons, C. P. (speaker) (18-11-2016). Glucocorticoid hormones preserve a population of adult hippocampal neural stem cells in the aging brain, Achucarro Basque Center for Neuroscience, Bilbao.
- Fitzsimons, C. P. (invited speaker) (18-11-2016). Glucocorticoid hormones preserve a population of adult hippocampal neural stem cells in the aging brain, Achucarro Basque Center for Neuroscience, Bilbao.
- Fitzsimons, C. P. (speaker) (1-11-2016). Two is better than one. Cooperative gene regulation by microRNAs in neural stem cells. MicroRNAs & Non-coding, RNAs. Europe 2016 Meeting, Cambridge.
- Fitzsimons, C. P. (invited speaker) (1-11-2016). Two is better than one. Cooperative gene regulation by microRNAs in neural stem cells. MicroRNAs & Non-coding, RNAs. Europe 2016 Meeting, Cambridge.
- Fitzsimons, C. P. (invited speaker) (27-10-2016). Two is better than one. Cooperative gene regulation by microRNAs in neural stem cells., Italian Institute of Technology, Genova.
- Fitzsimons, C. P. (invited speaker) (9-6-2016). Glucocorticoid hormones preserve a population of adult hippocampal neural stem cells in the aging brain., Dutch Neuroscience Meeting , Lunteren.
- Fitzsimons, C. P. (speaker) (2-5-2016). From stem to spine: the journey of a newborn neuron in an aging brain., SvBMT Protagoras Symposium The aging brain - slowing it down, Eindhoven.
- Fitzsimons, C. P. (speaker) (2-4-2016). Glucocorticoid hormones preserve a population of adult hippocampal neural stem cells in the aging brain..
- Fitzsimons, C. P. (invited speaker) (2-4-2016). Glucocorticoid hormones preserve a population of adult hippocampal neural stem cells in the aging brain, 18th International Neuroscience Winter Conference, Solden.
- Fitzsimons, C. P. (invited speaker) (5-11-2015). Role of microRNAs in Aberrant Hippocampal Neurogenesis Associated with Epilepsy., Invited lecture organized by the PhD Program of the Italian Institute of Technology, Genoa, Italy.
- Fitzsimons, C. P. (invited speaker) (11-7-2015). Epigenetics, neurogenesis and cognition: perspectives for drug development., Invited lecture at SUMMER SCHOOL OF NEUROSCIENCE, COGNITION, THE TARGET, Catania, Italy.
- Fitzsimons, C. P. (invited speaker) (8-5-2015). Ultradian glucocorticoid oscillations coordinate epigenetic programing of hippocampal neural stem/progenitor cell quiescence, Invited lecture at meeting Adult Neurogenesis: Evolution, Regulation and Function, Center for Regenerative Therapies, Dresden, Germany.
- Fitzsimons, C. P. (invited speaker) (16-1-2015). Glucocorticoid Hormones Preserve a Population of Adult Hippocampal Neural Stem Cells in the Aging brain., Invited lecture at the Department of Anatomy, Goethe University, Frankfurt, Germany.
- Fitzsimons, C. P. (invited speaker) (3-11-2014). From microRNA profiling to target regulation by cooperative microRNA action. Lessons learned from an experimental model of epilepsy., lecture at MicroRNAs & Non Coding RNAs Europe 2014 Meeting, University of Cambridge, Cambridge, United Kingdom.
- Fitzsimons, C. P. (invited speaker) (10-10-2014). Zooming in on synapses. Visualizing dendritic spines with super resolution microscopy., lecture at 7th Westerberger Herbsttagung on the Perspectives of Molecular Neurobiology, Department of Neurobiology, University of Osnabrück, Osnabrück, Germany.
- Fitzsimons, C. P. (invited speaker) (22-5-2014). Knockdown of the glucocorticoid receptor alters functional integration of newborn neurons in the adult hippocampus and impairs fear-motivated behavior., lecture at 12th Dutch Endo-Neuro-Psycho Meeting, ENP 2014, Lunteren, The Netherlands.
- Fitzsimons, C. P. (invited speaker) (4-4-2014). From microRNA profiling to target regulation by cooperative microRNA action., lecture at 2nd Benelux Congress on Physiology and Pharmacology, PhysPhar 2014, Maastricht, The Netherlands.
- Fitzsimons, C. P. (invited speaker) (25-9-2013). From stem to spine: regulation of adult hippocampal neurogenesis by stress hormones and microRNAs., lecture at SENC 2013, Oviedo, Spain.
- Fitzsimons, C. P. (invited speaker) (26-6-2013). Glucocorticod hormone exposure oscillations and the progression of adult hippocampal neurogenesis., invited lecture at the Eurogenesis Meeting, Bordeaux, France.
- Fitzsimons, C. P. (invited speaker) (28-11-2012). Changes in the cyclic pattern of stress hormone exposure and the progression of adult hippocampal neurogenesis., invited lecture at Donders Institute for brain, cognition and behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands.
- Fitzsimons, C. P. (invited speaker) (15-10-2012). Changes in the cyclic pattern of stress hormone exposure and the progression of adult hippocampal neurogenesis., invited lecture at SFN meeting 2012, New Orleans, USA.
- Fitzsimons, C. P. (invited speaker) (12-7-2012). Changes in the cyclic pattern of stress hormone exposure and the progression of adult hippocampal neurogenesis., invited lecture at the Regulation of adult neurogenesis symposium, satellite event of the FENS Forum, Barcelona, Spain.
Andere
- Fitzsimons, C. P. (organiser) (1-1-2017 - 30-6-2017). Organizing Committee for the Brain Day, Amsterdam Brain & Cognition (ABC), Amsterda. Member of the Organizing Committee for the Brain Day, Amsterdam Brain & Cognition (ABC) (organising a conference, workshop, ...). http://abc.uva.nl/content/events/conferences/2017/06/brain-day-night-2017.html
2025
2017
2015
2012
- Leiria Verissimo, C. S. (2012). Doublecortin-like kinase : a potential therapeutic target for neuroblastoma.
2021
- Bielefeld, P., Davidson, A., Reijner, N., Abiega Etxabe, O., Lucassen, P. J., Fitzsimons, C. P., Abbink, M. R. & Korosi, A. (2021). Early life stress decreases cell proliferation and the number of putative adult neural stem cells in the adult hypothalamus. Taylor & Francis. https://doi.org/10.6084/m9.figshare.14035256.v1
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Nevenwerkzaamheden
- Geen nevenwerkzaamheden
Bielefeld, P., Martirosyan, A., Martín-Suárez, S., Apresyan, A., Meerhoff, G. F., Pestana, F., Poovathingal, S., Reijner, N., Koning, W., Clement, R. A., Van der Veen, I., Toledo, E. M., Polzer, O., Durá, I., Hovhannisyan, S., Nilges, B. S., Bogdoll, A., Kashikar, N. D., Lucassen, P. J., ... Fitzsimons, C. P. (2024). Traumatic brain injury promotes neurogenesis at the cost of astrogliogenesis in the adult hippocampus of male mice. Nature Communications, 15, Article 5222.