Prof. dr. T.W.J. (Dorus) Gadella
Faculteit der Natuurwetenschappen, Wiskunde en Informatica
Swammerdam Institute for Life Sciences
Bezoekadres
- Science Park 904
- Kamernummer: C2.266
Postadres
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Postbus 1212
1000 BE Amsterdam
Contactgegevens
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Publicaties
2024
- Goedhart, J., & Gadella, T. W. J. (2024). Breaking up the StayGold dimer yields three photostable monomers. Nature Methods, 21(4), 558-559. https://doi.org/10.1038/s41592-024-02223-8
2023
- Gadella, T. W. J., van Weeren, L., Stouthamer, J., Hink, M. A., Wolters, A. H. G., Giepmans, B. N. G., Aumonier, S., Dupuy, J., & Royant, A. (2023). mScarlet3: a brilliant and fast-maturing red fluorescent protein. Nature Methods, 20(4), 541-545. https://doi.org/10.1038/s41592-023-01809-y [details]
Rehó, B., Fadel, L., Brazda, P., Benziane, A., Hegedüs, É., Sen, P., Gadella, T. W. J., Tóth, K., Nagy, L., & Vámosi, G. (2023). Agonist-controlled competition of RAR and VDR nuclear receptors for heterodimerization with RXR is manifested in their DNA binding. The Journal of Biological Chemistry, 299(2), Article 102896. https://doi.org/10.1016/j.jbc.2023.102896 [details]
2022
- Chavez Abiega, S., Grönloh, M. L. B., Gadella, T. W. J., Bruggeman, F. J., & Goedhart, J. (2022). Single-cell imaging of ERK and Akt activation dynamics and heterogeneity induced by G-protein-coupled receptors. Journal of Cell Science, 135(6), Article 259685. https://doi.org/10.1242/jcs.259685 [details]
- Gadella, T. W. J. (2022). New near-infrared fluorescent probes and tools. Nature Methods, 19(6), 654-655. Advance online publication. https://doi.org/10.1038/s41592-022-01425-2 [details]
- Heesink, G., Caron, C., van Leijenhorst-Groener, K., Molenaar, R., Gadella, T. W. J., Claessens, M. M. A. E., & Blum, C. (2022). Quantification of Dark Protein Populations in Fluorescent Proteins by Two-Color Coincidence Detection and Nanophotonic Manipulation. The journal of Physical Chemistry. B, 126(40), 7906-7915. https://doi.org/10.1021/acs.jpcb.2c04627 [details]
2021
- Mahlandt, E. K., Arts, J. J. G., van der Meer, W. J., van der Linden, F. H., Tol, S., van Buul, J. D., Gadella, T. W. J., & Goedhart, J. (2021). Visualizing endogenous Rho activity with an improved localization-based, genetically encoded biosensor. Journal of Cell Science, 134(17), Article 258823. https://doi.org/10.1242/jcs.258823 [details]
- Reinhard, N. R., Van Der Niet, S., Chertkova, A., Postma, M., Hordijk, P. L., Gadella, T. W. J., & Goedhart, J. (2021). Identification of guanine nucleotide exchange factors that increase Cdc42 activity in primary human endothelial cells. Small GTPases, 12(3), 226-240. Advance online publication. https://doi.org/10.1080/21541248.2019.1658509 [details]
- van der Linden, F. H., Mahlandt, E. K., Arts, J. J. G., Beumer, J., Puschhof, J., de Man, S. M. A., Chertkova, A. O., Ponsioen, B., Clevers, H., van Buul, J. D., Postma, M., Gadella Jr., T. W. J., & Goedhart, J. (2021). A turquoise fluorescence lifetime-based biosensor for quantitative imaging of intracellular calcium. Nature Communications, 12, Article 7159. https://doi.org/10.1038/s41467-021-27249-w [details]
2020
- Bindels, D. S., Postma, M., Haarbosch, L., van Weeren, L., & Gadella, T. W. J. (2020). Multiparameter screening method for developing optimized red-fluorescent proteins. Nature Protocols, 15(2), 450-478. https://doi.org/10.1038/s41596-019-0250-7 [details]
- Prangsma, J. C., Molenaar, R., van Weeren, L., Bindels, D. S., Haarbosch, L., Stouthamer, J., Gadella, T. W. J., Subramaniam, V., Vos, W. L., & Blum, C. (2020). Quantitative Determination of Dark Chromophore Population Explains the Apparent Low Quantum Yield of Red Fluorescent Proteins. The journal of Physical Chemistry. B, 124(8), 1383-1391. https://doi.org/10.1021/acs.jpcb.9b10396 [details]
- Van Geel, O., Cheung, S., & Gadella, T. W. J. (2020). Combining optogenetics with sensitive FRET imaging to monitor local microtubule manipulations. Scientific Reports, 10, Article 6034. https://doi.org/10.1038/s41598-020-62874-3 [details]
- Van Geel, O., Hartsuiker, R., & Gadella, T. W. J. (2020). Increasing spatial resolution of photoregulated GTPases through immobilized peripheral membrane proteins. Small GTPases, 11(6), 441-450. Advance online publication. https://doi.org/10.1080/21541248.2018.1507411 [details]
2018
- Long, Y., Stahl, Y., Weidtkamp-Peters, S., Smet, W., Du, Y., Gadella Jr., T. W. J., Goedhart, J., Scheres, B., & Blilou, I. (2018). Optimizing FRET-FLIM Labeling Conditions to Detect Nuclear Protein Interactions at Native Expression Levels in Living Arabidopsis Roots. Frontiers in Plant Science, 9, Article 639. https://doi.org/10.3389/fpls.2018.00639 [details]
- Mastop, M., Reinhard, N. R., Zuconelli, C. R., Terwey, F., Gadella, T. W. J., van Unen, J., Adjobo-Hermans, M. J. W., & Goedhart, J. (2018). A FRET-based biosensor for measuring Gα13 activation in single cells. PLoS ONE, 13(3), Article e0193705. https://doi.org/10.1371/journal.pone.0193705 [details]
- Mastop, M., Reinhard, N. R., Zuconelli, C. R., Terwey, F., Gadella, T. W. J., van Unen, J., Adjobo-Hermans, M. J. W., & Goedhart, J. (2018). Correction: A FRET-based biosensor for measuring Gα13 activation in single cells. PLoS ONE, 13(4), Article e0195649. https://doi.org/10.1371/journal.pone.0195649
- van Unen, J., Botman, D., Yin, T., Wu, Y. I., Hink, M. A., Gadella, T. W. J., Postma, M., & Goedhart, J. (2018). The C-terminus of the oncoprotein TGAT is necessary for plasma membrane association and efficient RhoA-mediated signaling. BMC Cell Biology, 19, Article 6. https://doi.org/10.1186/s12860-018-0155-2 [details]
2017
- Bindels, D. S., Haarbosch, L., van Weeren, L., Postma, M., Wiese, K. E., Mastop, M., Aumonier, S., Gotthard, G., Royant, A., Hink, M. A., & Gadella Jr, T. W. J. (2017). mScarlet: a bright monomeric red fluorescent protein for cellular imaging. Nature Methods, 14(1), 53-56. Advance online publication. https://doi.org/10.1038/nmeth.4074 [details]
- Long, Y., Stahl, Y., Weidtkamp-Peters, S., Postma, M., Zhou, W., Goedhart, J., Sánchez-Pérez, M-I., Gadella, T. W. J., Simon, R., Scheres, B., & Blilou, I. (2017). In vivo FRET–FLIM reveals cell-type-specific protein interactions in Arabidopsis roots. Nature, 548(7665), 97-102. https://doi.org/10.1038/nature23317 [details]
- Mastop, M., Bindels, D. S., Shaner, N. C., Postma, M., Gadella, T. W. J., & Goedhart, J. (2017). Characterization of a spectrally diverse set of fluorescent proteins as FRET acceptors for mTurquoise2. Scientific Reports, 7, Article 11999. https://doi.org/10.1038/s41598-017-12212-x [details]
- Reinhard, N. R., Mastop, M., Yin, T., Wu, Y., Bosma, E. K., Gadella, T. W. J., Goedhart, J., & Hordijk, P. L. (2017). The balance between Gαi-Cdc42/Rac and Gα12/13-RhoA pathways determines endothelial barrier regulation by sphingosine-1-phosphate. Molecular Biology of the Cell, 28(23), 3371-3382. https://doi.org/10.1091/mbc.E17-03-0136 [details]
- Vermeer, J. E. M., van Wijk, R., Goedhart, J., Geldner, N., Chory, J., Gadella, T. W. J., & Munnik, T. (2017). In Vivo Imaging of Diacylglycerol at the Cytoplasmic Leaflet of Plant Membranes. Plant and Cell Physiology, 58(7), 1196-1207. https://doi.org/10.1093/pcp/pcx012 [details]
2016
- Raspe, M., Kedziora, K. M., van den Broek, B., Zhao, Q., de Jong, S., Herz, J., Mastop, M., Goedhart, J., Gadella, T. W. J., Young, I. T., & Jalink, K. (2016). siFLIM: single-image frequency-domain FLIM provides fast and photon-efficient lifetime data. Nature Methods, 13(6), 501-504. https://doi.org/10.1038/NMETH.3836 [details]
- Reinhard, N. R., van Helden, S. F., Anthony, E. C., Yin, T., Wu, Y. I., Goedhart, J., Gadella, T. W. J., & Hordijk, P. L. (2016). Spatiotemporal analysis of RhoA/B/C activation in primary human endothelial cells. Scientific Reports, 6, Article 25502. https://doi.org/10.1038/srep25502 [details]
- van Unen, J., Rashidfarrokhi, A., Hoogendoorn, E., Postma, M., Gadella, T. W. J., & Goedhart, J. (2016). Quantitative Single-Cell Analysis of Signaling Pathways Activated Immediately Downstream of Histamine Receptor Subtypes. Molecular Pharmacology, 90(3), 162-176. https://doi.org/10.1124/mol.116.104505 [details]
- van Unen, J., Stumpf, A. D., Schmid, B., Reinhard, N. R., Hordijk, P. L., Hoffmann, C., Gadella (jr.), T. W. J., & Goedhart, J. (2016). A New Generation of FRET Sensors for Robust Measurement of Gαi1, Gαi2 and Gαi3 Activation Kinetics in Single Cells. PLoS ONE, 11(1), Article e0146789. https://doi.org/10.1371/journal.pone.0146789 [details]
- van Unen, J., Yin, T., Wu, Y. I., Mastop, M., Gadella, T. W. J., & Goedhart, J. (2016). Kinetics of recruitment and allosteric activation of ARHGEF25 isoforms by the heterotrimeric G-protein Gαq. Scientific Reports, 6, Article 36825. https://doi.org/10.1038/srep36825 [details]
2015
- Long, Y., Goedhart, J., Schneijderberg, M., Terpestra, I., Shimotohno, A., Bouchet, B. P., Akhmanova, A., Gadella (jr.), T. W. J., Heidstra, R., Scheres, B., & Blilou, I. (2015). SCARECROW-LIKE23 and SCARECROW jointly specify endodermal cell fate but distinctly control SHORT-ROOT movement. Plant Journal, 84(4), 773-784. https://doi.org/10.1111/tpj.13038 [details]
- Timmerman, I., Heemskerk, N., Kroon, J., Schaefer, A., van Rijssel, J., Hoogenboezem, M., van Unen, J., Goedhart, J., Gadella, T. W. J., Yin, T., Wu, Y., Huveneers, S., & van Buul, J. D. (2015). A local VE-cadherin and Trio-based signaling complex stabilizes endothelial junctions through Rac1. Journal of Cell Science, 128(16), 3041-3054. Advance online publication. https://doi.org/10.1242/jcs.168674 [details]
- van Unen, J., Reinhard, N. R., Yin, T., Wu, Y. I., Postma, M., Gadella, T. W. J., & Goedhart, J. (2015). Plasma membrane restricted RhoGEF activity is sufficient for RhoA-mediated actin polymerization. Scientific Reports, 5, Article 14693. https://doi.org/10.1038/srep14693 [details]
2014
- Bindels, D. S., Goedhart, J., Hink, M. A., van Weeren, L., Joosen, L., & Gadella (jr.), T. W. J. (2014). Optimization of fluorescent proteins. In Y. Engelborghs, & A. J. W. G. Visser (Eds.), Fluorescence Spectroscopy and Microscopy: Methods and Protocols (pp. 371-417). (Methods in Molecular Biology; Vol. 1076). Humana Press. https://doi.org/10.1007/978-1-62703-649-8_16 [details]
- Hoogendoorn, E., Crosby, K. C., Leyton-Puig, D., Breedijk, R. M. P., Jalink, K., Gadella, T. W. J., & Postma, M. (2014). The fidelity of stochastic single-molecule super-resolution reconstructions critically depends upon robust background estimation. Scientific Reports, 4, Article 3854. https://doi.org/10.1038/srep03854 [details]
- Joosen, L., Hink, M. A., Gadella, T. W. J., & Goedhart, J. (2014). Effect of fixation procedures on the fluorescence lifetimes of Aequorea victoria derived fluorescent proteins. Journal of Microscopy, 256(3), 166-176. https://doi.org/10.1111/jmi.12168 [details]
- Moling, S., Pietraszewska-Bogiel, A., Postma, M., Fedorova, E., Hink, M. A., Limpens, E., Gadella, T. W. J., & Bisseling, T. (2014). Nod factor receptors form heteromeric complexes and are essential for intracellular infection in medicago nodules. The Plant Cell, 26(10), 4188-4199. https://doi.org/10.1105/tpc.114.129502 [details]
2013
- Adjobo-Hermans, M. J. W., Crosby, K. C., Putyrski, M., Bhageloe, A., van Weeren, L., Schultz, C., Goedhart, J., & Gadella (jr.), T. W. J. (2013). PLCbeta isoforms differ in their subcellular location and their CT-domain dependent interaction with Galphaq. Cellular Signalling, 25(1), 255-263. Advance online publication. https://doi.org/10.1016/j.cellsig.2012.09.022 [details]
- Bilan, D. S., Pase, L., Joosen, L., Gorokhovatsky, A. Y., Ermakova, Y. G., Gadella, T. W. J., Grabher, C., Schultz, C., Lukyanov, S., & Belousov, V. V. (2013). HyPer-3: A Genetically Encoded H(2)O(2) Probe with Improved Performance for Ratiometric and Fluorescence Lifetime Imaging. ACS Chemical Biology, 8(3), 535-542. Advance online publication. https://doi.org/10.1021/cb300625g [details]
- Crosby, K. C., Postma, M., Hink, M. A., Zeelenberg, C. H. C., Adjobo-Hermans, M. J. W., & Gadella, T. W. J. (2013). Quantitative analysis of self-association and mobility of annexin A4 at the plasma membrane. Biophysical Journal, 104(9), 1875-1885. https://doi.org/10.1016/j.bpj.2013.02.057 [details]
- Goedhart, J., van Unen, J., Adjobo-Hermans, M. J. W., & Gadella (jr.), T. W. J. (2013). Signaling efficiency of Gαq through its effectors p63RhoGEF and GEFT depends on their subcellular location. Scientific Reports, 3, Article 2284. https://doi.org/10.1038/srep02284 [details]
- Pietraszewska-Bogiel, A., Lefebvre, B., Koini, M. A., Klaus-Heisen, D., Takken, F. L. W., Geurts, R., Cullimore, J. V., & Gadella, T. W. J. (2013). Interaction of Medicago truncatula Lysin Motif Receptor-Like Kinases, NFP and LYK3, Produced in Nicotiana benthamiana Induces Defence-Like Responses. PLoS ONE, 8(6), Article e65055. https://doi.org/10.1371/journal.pone.0065055 [details]
2012
- Goedhart, J., von Stetten, D., Noirclerc-Savoye, M., Lelimousin, M., Joosen, L., Hink, M. A., van Weeren, L., Gadella, T. W. J., & Royant, A. (2012). Structure-guided evolution of cyan fluorescent proteins towards a quantum yield of 93%. Nature Communications, 3, 751. https://doi.org/10.1038/ncomms1738 [details]
- Shcherbakova, D. M., Hink, M. A., Joosen, L., Gadella, T. W. J., & Verkhusha, V. V. (2012). An orange fluorescent protein with a large Stokes shift for single-excitation multicolor FCCS and FRET imaging. Journal of the American Chemical Society, 134(18), 7913-7923. https://doi.org/10.1021/ja3018972 [details]
- von Stetten, D., Noirclerc-Savoye, M., Goedhart, J., Gadella, T. W. J., & Royant, A. (2012). Structure of a fluorescent protein from Aequorea victoria bearing the obligate-monomer mutation A206K. Acta Crystallographica. Section F: Structural Biology and Crystallization Communications, 68(8), 878-882. https://doi.org/10.1107/S1744309112028667 [details]
2011
- Adjobo-Hermans, M. J. W., Goedhart, J., van Weeren, L., Nijmeijer, S., Manders, E. M. M., Offermanns, S., & Gadella (jr.), T. W. J. (2011). Real-time visualization of heterotrimeric G protein Gq activation in living cells. BMC Biology, 9, Article 32. https://doi.org/10.1186/1741-7007-9-32 [details]
- Crosby, K. C., Pietraszewska-Bogiel, A., Gadella (jr.), T. W. J., & Winkel, B. S. J. (2011). Förster resonance energy transfer demonstrates a flavonoid metabolon in living plant cells that displays competitive interactions between enzymes. FEBS Letters, 585(14), 2193-2198. https://doi.org/10.1016/j.febslet.2011.05.066 [details]
- Goedhart, J., & Gadella (jr.), T. W. J. (2011). Bypassing GPCRs with chemical dimerizers. Chemistry & Biology, 18(9), 1067-1068. https://doi.org/10.1016/j.chembiol.2011.09.004 [details]
- Goedhart, J., van Weeren, L., Adjobo-Hermans, M. J. W., Elzenaar, I., Hink, M. A., & Gadella (jr.), T. W. J. (2011). Quantitative co-expression of proteins at the single cell level - application to a multimeric FRET sensor. PLoS ONE, 6(11), Article e27321. https://doi.org/10.1371/journal.pone.0027321 [details]
- Klarenbeek, J. B., Goedhart, J., Hink, M. A., Gadella, T. W. J., & Jalink, K. (2011). A mTurquoise-based cAMP sensor for both FLIM and ratiometric read-out has improved dynamic range. PLoS ONE, 6(4), Article e19170. https://doi.org/10.1371/journal.pone.0019170 [details]
- Klaus-Heisen, D., Nurisso, A., Pietraszewska-Bogiel, A., Mbengue, M., Camut, S., Timmers, T., Pichereaux, C., Rossignol, M., Gadella, T. W. J., Imberty, A., Lefebvre, B., & Cullimore, J. V. (2011). Structure-function similarities between a plant receptor-like kinase and the human interleukin-1 receptor-associated kinase-4. The Journal of Biological Chemistry, 286(13), 11202-11210. https://doi.org/10.1074/jbc.M110.186171 [details]
- Pietraszewska-Bogiel, A., & Gadella, T. W. J. (2011). FRET microscopy: from principle to routine technology in cell biology. Journal of Microscopy, 241(2), 111-118. https://doi.org/10.1111/j.1365-2818.2010.03437.x [details]
2010
- Alexeeva, S., Gadella (jr.), T. W. J., Verheul, J., Verhoeven, G. S., & den Blaauwen, T. (2010). Direct interactions of early and late assembling division proteins in Escherichia coli cells resolved by FRET. Molecular Microbiology, 77(2), 384-398. https://doi.org/10.1111/j.1365-2958.2010.07211.x [details]
- Goedhart, J., van Weeren, L., Hink, M. A., Vischer, N. O. E., Jalink, K., & Gadella (jr.), T. W. J. (2010). Bright cyan fluorescent protein variants identified by fluorescence lifetime screening. Nature Methods, 7(2), 137-139. https://doi.org/10.1038/NMETH.1415 [details]
- Schultz, C., Neef, A. B., Gadella Jr, T. W. J., & Goedhart, J. (2010). Imaging lipids in living cells. Cold Spring Harbor protocols, 2010(7), Article pdb.top83. https://doi.org/10.1101/pdb.top83 [details]
- Schultz, C., Neef, A. B., Gadella Jr, T. W., & Goedhart, J. (2010). Labeling lipids for imaging fixed cells. Cold Spring Harbor protocols, 5(7), Article pdb.prot5458. https://doi.org/10.1101/pdb.prot5458 [details]
- Schultz, C., Neef, A. B., Gadella Jr, T. W., & Goedhart, J. (2010). Labeling lipids for imaging in live cells. Cold Spring Harbor protocols, 5(7), Article pdb.prot5459. https://doi.org/10.1101/pdb.prot5459 [details]
- Subach, F. V., Zhang, L., Gadella, T. W. J., Gurskaya, N. G., Lukyanov, K. A., & Verkhusha, V. V. (2010). Red fluorescent protein with reversibly photoswitchable absorbance for photochromic FRET. Chemistry & Biology, 17(7), 745-755. https://doi.org/10.1016/j.chembiol.2010.05.022 [details]
2009
- Shcherbo, D., Souslova, E. A., Goedhart, J., Chepurnykh, T. V., Gaintzeva, A., Shemiakina, I. I., Gadella, T. W. J., Lukyanov, S., & Chudakov, D. M. (2009). Practical and reliable FRET/FLIM pair of fluorescent proteins. BMC Biotechnology, 9, 24. https://doi.org/10.1186/1472-6750-9-24 [details]
- Vermeer, J. E. M., Thole, J. M., Goedhart, J., Nielsen, E., Munnik, T., & Gadella, T. W. J. (2009). Imaging phosphatidylinositol 4-phosphate dynamics in living plant cells. Plant Journal, 57(2), 356-372. https://doi.org/10.1111/j.1365-313X.2008.03679.x [details]
2008
- Adjobo-Hermans, M. J. W., Goedhart, J., & Gadella, T. W. J. (2008). Regulation of PLCβ1a membrane anchoring by its substrate phosphatidylinositol (4,5)-bisphosphate. Journal of Cell Science, 121(22), 3770-3777. https://doi.org/10.1242/jcs.029785 [details]
- Dhonukshe, P., Grigoriev, I., Fischer, R., Tominaga, M., Robinson, D. G., Hašek, J., Paciorek, T., Petrášek, J., Seifertová, D., Tejos, R., Meisel, L. A., Zažímalová, E., Gadella (jr.), T. W. J., Stierhof, Y-D., Ueda, T., Oiwa, K., Akhmanova, A., Brock, R., Spang, A., & Friml, J. (2008). Auxin transport inhibitors impair vesicle motility and actin cytoskeleton dynamics in diverse eukaryotes. Proceedings of the National Academy of Sciences of the United States of America, 105(11), 4489-4494. https://doi.org/10.1073/pnas.0711414105 [details]
- Kremers, G. J., van Munster, E. B., Goedhart, J., & Gadella, T. W. J. (2008). Quantitative lifetime unmixing of multiexponentially decaying fluorophores using single-frequency fluorescence lifetime imaging microscopy. Biophysical Journal, 95(1), 378-389. https://doi.org/10.1529/biophysj.107.125229 [details]
- Rino, J., Desterro, J. M. P., Pacheco, T. R., Gadella (jr.), T. W. J., & Carmo-Fonseca, M. (2008). Splicing factors SF1 and U2AF associate in extraspliceosomal complexes. Molecular and Cellular Biology, 28(9), 3045-3057. https://doi.org/10.1128/MCB.02015-07 [details]
- Schenning, M., Goedhart, J., Gadella (jr.), T. W. J., Avram, D., Wirtz, K. W. A., & Snoek, G. T. (2008). The anti-apoptotic activity associated with phosphatidylinositol transfer protein α activates the MAPK and Akt/PKB pathway. Biochimica et Biophysica Acta-Molecular Cell Research, 1783(10), 1700-1706. https://doi.org/10.1016/j.bbamcr.2008.04.014 [details]
- Thole, J. M., Vermeer, J. E. M., Zhang, Y., Gadella, T. W. J., & Nielsen, E. (2008). Root hair defective4 encodes a phosphatidylinositol-4-phosphate phosphatase required for proper root hair development in Arabidopsis thaliana. The Plant Cell, 20(2), 381-395. https://doi.org/10.1105/tpc.107.054304 [details]
2021
- Chavez-Abiega, S., Grönloh, M. L. B., Gadella, T. W. J., Bruggeman, F. J., & Goedhart, J. (2021). Heterogeneity and dynamics of ERK and Akt activation by G protein-coupled receptors depend on the activated heterotrimeric G proteins. (v3 ed.) BioRxiv. https://doi.org/10.1101/2021.07.27.453948 [details]
2015
- Timmerman, I., Heemskerk, N., Kroon, J., Schaefer, A., van Rijssel, J., Hoogenboezem, M., van Unen, J., Goedhart, J., Gadella, T. W. J., Yin, T., Wu, Y., Huveneers, S., & van Buul, J. D. (2015). A local VE-cadherin and Trio-based signaling complex stabilizes endothelial junctions through Rac1: Correction. Journal of Cell Science, 128(18), 3514. https://doi.org/10.1242/jcs.179424
2010
- Schultz, C., Neef, A. B., Gadella Jr, T. W. J., & Goedhart, J. (2010). Transfection of cells with DNA encoding a visible fluorescent protein-tagged lipid-binding domain. Cold Spring Harbor protocols, 2010(7), Article pdb.top83. https://doi.org/10.1101/pdb.prot5457 [details]
2009
- Gadella, T. W. J. (2009). FRET and FLIM techniques. (Laboratory techniques in biochemistry and molecular biology; No. 33). Elsevier. [details]
- Goedhart, J., & Gadella (jr.), T. W. J. (2009). Fluorescence resonance energy transfer imaging of PKC signalling in living cells using genetically encoded fluorescent probes. Journal of the Royal Society Interface, 6(S1), S27-S34. https://doi.org/10.1098/rsif.2008.0340.focus [details]
2023
- Gadella, T. W. J., van Weeren, L., Stouthamer, J., Hink, M. A., Wolters, A. H. G., Giepmans, B. N. G., Aumonier, S., Dupuy, J. & Royant, A. (5-4-2023). Structure of the red fluorescent protein mScarlet3 at pH 7.5. Protein Data Bank (PDB). https://doi.org/10.2210/pdb7zct/pdb
2019
- Bindels, D., Postma, M., Haarbosch, L., van Weeren, L. & Jr, T. (2019). Test data set for macros accompanying the publication Multi-parameter screening method for developing optimized red fluorescent proteins. Zenodo. https://doi.org/10.5281/zenodo.3347150
2017
- Mastop, M., Bindels, D., Gadella, D. & Goedhart, J. (16-5-2017). Absorption and Emission spectra of fluorescent proteins. Zenodo. https://doi.org/10.5281/zenodo.580169
2016
- Bindels, D., Haarbosch, L., van Weeren, L., Postma, M., Wiese, K., Mastop, M., Aumonier, S., Gotthard, G., Royant, A., Hink, M. A. & Gadella, T. W. J. (7-12-2016). Structure of the Red Fluorescent Protein mScarlet at pH 7.8. Protein Data Bank (PDB). https://doi.org/10.2210/pdb5LK4/pdb
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Nevenwerkzaamheden
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Van Leeuwenhoek Centre Adv. Microscopy
Directeur -
Centr. Advanced BioImaging U. Copenhagen
Member Scientific Advisory Board -
Euro-BioImaging Board
Member
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Van Leeuwenhoek Centre Adv. Microscopy
Rehó, B., Fadel, L., Brazda, P., Benziane, A., Hegedüs, É., Sen, P., Gadella, T. W. J., Tóth, K., Nagy, L., & Vámosi, G. (2023). Agonist-controlled competition of RAR and VDR nuclear receptors for heterodimerization with RXR is manifested in their DNA binding. The Journal of Biological Chemistry, 299(2), Article 102896.