Prof. dr. I. (Inge) Huitinga
Faculteit der Natuurwetenschappen, Wiskunde en Informatica
Swammerdam Institute for Life Sciences
Bezoekadres
- Science Park 904
Postadres
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Postbus 94232
1090 GE Amsterdam
Contactgegevens
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Publicaties
2024
Mekkes, N. J., Groot, M., Hoekstra, E., de Boer, A., Dagkesamanskaia, E., Bouwman, S., Wehrens, S. M. T., Herbert, M. K., Wever, D. D., Rozemuller, A., Eggen, B. J. L., Huitinga, I., & Holtman, I. R. (2024). Identification of clinical disease trajectories in neurodegenerative disorders with natural language processing. Nature medicine, 30(4), 1143-1153. https://doi.org/10.1038/s41591-024-02843-9 [details]- Smolders, J., Hamann, J., & Huitinga, I. (2024). Modification of T- and B-cell-associated immuno-pathologic mechanisms in multiple sclerosis by disease modifying therapies: Achievements and opportunities. In M. J. Aminoff, F. Boller, & D. F. Swaab (Eds.), Handbook of Clinical Neurology (pp. 7-21). (Handbook of Clinical Neurology; Vol. 202). Elsevier B.V. https://doi.org/10.1016/B978-0-323-90242-7.00016-X
- de Vries, L. E., Huitinga, I., Kessels, H. W., Swaab, D. F., & Verhaagen, J. (2024). The concept of resilience to Alzheimer's Disease: current definitions and cellular and molecular mechanisms. Molecular Neurodegeneration, 19, Article 33. https://doi.org/10.1186/s13024-024-00719-7 [details]
- van den Bosch, A. M. R., Wever, D., Schonewille, P., Schuller, S. L., Smolders, J., Hamann, J., & Huitinga, I. (2024). Cortical CD200–CD200R and CD47–SIRPα expression is associated with multiple sclerosis pathology. Brain Communications, 6(4), Article fcae264. https://doi.org/10.1093/braincomms/fcae264 [details]
2023
- Hsiao, C. C., Engelenburg, H. J., Jongejan, A., Zhu, J., Zhang, B., Mingueneau, M., Moerland, P. D., Huitinga, I., Smolders, J., & Hamann, J. (2023). Osteopontin associates with brain TRM-cell transcriptome and compartmentalization in donors with and without multiple sclerosis. iScience, 26(1), Article 105785. https://doi.org/10.1016/j.isci.2022.105785 [details]
- International Multiple Sclerosis Genetics Consortium, & MultipleMS Consortium (2023). Locus for severity implicates CNS resilience in progression of multiple sclerosis. Nature, 619(7969), 323–331. https://doi.org/10.1038/s41586-023-06250-x [details]
- Scheepstra, K. W. F., Mizee, M. R., van Scheppingen, J., Adelia, A., Wever, D. D., Mason, M. R. J., Dubbelaar, M. L., Hsiao, C. C., Eggen, B. J. L., Hamann, J., & Huitinga, I. (2023). Microglia Transcriptional Profiling in Major Depressive Disorder Shows Inhibition of Cortical Gray Matter Microglia. Biological Psychiatry, 94(8), 619-629. https://doi.org/10.1016/j.biopsych.2023.04.020 [details]
- van den Bosch, A. M. R., Hümmert, S., Steyer, A., Ruhwedel, T., Hamann, J., Smolders, J., Nave, K. A., Stadelmann, C., Kole, M. H. P., Möbius, W., & Huitinga, I. (2023). Ultrastructural Axon–Myelin Unit Alterations in Multiple Sclerosis Correlate with Inflammation. Annals of Neurology, 93(4), 856-870. https://doi.org/10.1002/ana.26585 [details]
2021
- Zhang, L., Verwer, R. W. H., Zhao, J., Huitinga, I., Lucassen, P. J., & Swaab, D. F. (2021). Changes in glial gene expression in the prefrontal cortex in relation to major depressive disorder, suicide and psychotic features. Journal of Affective Disorders, 295, 893-903. https://doi.org/10.1016/j.jad.2021.08.098 [details]
2020
- Böttcher, C., van der Poel, M., Fernández-Zapata, C., Schlickeiser, S., Leman, J. K. H., Hsiao, C.-C., Mizee, M. R., Adelia, Vincenten, M. C. J., Kunkel, D., Huitinga, I., Hamann, J., & Priller, J. (2020). Single-cell mass cytometry reveals complex myeloid cell composition in active lesions of progressive multiple sclerosis. Acta Neuropathologica Communications, 8, Article 136. https://doi.org/10.1186/s40478-020-01010-8 [details]
- Fransen, N. L., Hsiao, C-C., van der Poel, M., Engelenburg, H. J., Verdaasdonk, K., Vincenten, M. C. J., Remmerswaal, E. B. M., Kuhlmann, T., Mason, M. R. J., Hamann, J., Smolders, J., & Huitinga, I. (2020). Tissue-resident memory T cells invade the brain parenchyma in multiple sclerosis white matter lesions. Brain, 143(6), 1714-1730. https://doi.org/10.1093/brain/awaa117 [details]
- Korotkov, A., Puhakka, N., Das Gupta, S., Vuokila, N., Broekaart, D. W. M., Anink, J. J., Heiskanen, M., Karttunen, J., van Scheppingen, J., Huitinga, I., Mills, J. D., van Vliet, E. A., Pitkänen, A., & Aronica, E. (2020). Increased expression of miR142 and miR155 in glial and immune cells after traumatic brain injury may contribute to neuroinflammation via astrocyte activation. Brain Pathology, 30(5), 897-912. https://doi.org/10.1111/bpa.12865 [details]
- Zhang, L., Verwer, R. W. H., Lucassen, P. J., Huitinga, I., & Swaab, D. F. (2020). Prefrontal cortex alterations in glia gene expression in schizophrenia with and without suicide. Journal of Psychiatric Research, 121, 31-38. https://doi.org/10.1016/j.jpsychires.2019.11.002 [details]
- Zhang, L., Verwer, R. W. H., Lucassen, P. J., Huitinga, I., & Swaab, D. F. (2020). Sex difference in glia gene expression in the dorsolateral prefrontal cortex in bipolar disorder: Relation to psychotic features. Journal of Psychiatric Research, 125, 66-74. https://doi.org/10.1016/j.jpsychires.2020.03.003 [details]
- van der Poel, M., Hoepel, W., Hamann, J., Huitinga, I., & den Dunnen, J. (2020). IgG Immune Complexes Break Immune Tolerance of Human Microglia. The journal of immunology, 205(9), 2511-2518. https://doi.org/10.4049/jimmunol.2000130 [details]
2021
- Hsiao, C-C., Fransen, N. L., van den Bosch, A. M. R., Brandwijk, K. I. M., Huitinga, I., Hamann, J., & Smolders, J. (2021). White matter lesions in multiple sclerosis are enriched for CD20dim CD8+ tissue-resident memory T cells. European journal of immunology, 51(2), 483-486. Advance online publication. https://doi.org/10.1002/eji.202048665 [details]
2025
- Penning, A. R. A. (2025). Small RNA, big impact: Profiling the therapeutic potential of microRNA-132 in Alzheimer's disease. [Thesis, fully internal, Universiteit van Amsterdam]. [details]
- Tosoni, G. (2025). New neurons, old questions: Cellular and molecular insights into the neurogenesis debate in Alzheimer’s disease. [Thesis, fully internal, Universiteit van Amsterdam]. [details]
2024
2021
2020
- Kalsbeek, M. J. T. (2020). Neuron-glia interactions in patients with type 2 diabetes. [Thesis, externally prepared, Universiteit van Amsterdam]. [details]
- van der Poel, M. (2020). Diversity of microglia: Their contribution to multiple sclerosis lesion formation. [Thesis, externally prepared, Universiteit van Amsterdam]. [details]
2024
- de Vries, L. E., Jongejan, A., Monteiro Fortes, J., Balesar, R., Rozemuller, A. J. M., Moerland, P. D., Huitinga, I., Swaab, D. F. & Verhaagen, J. (2024). Additional file 1 of Gene-expression profiling of individuals resilient to Alzheimer's disease reveals higher expression of genes related to metallothionein and mitochondrial processes and no changes in the unfolded protein response. Figshare. https://doi.org/10.6084/m9.figshare.26712275.v1
- de Vries, L. E., Jongejan, A., Monteiro Fortes, J., Balesar, R., Rozemuller, A. J. M., Moerland, P. D., Huitinga, I., Swaab, D. F. & Verhaagen, J. (2024). Additional file 3 of Gene-expression profiling of individuals resilient to Alzheimer's disease reveals higher expression of genes related to metallothionein and mitochondrial processes and no changes in the unfolded protein response. Figshare. https://doi.org/10.6084/m9.figshare.26712281.v1
- de Vries, L. E., Jongejan, A., Monteiro Fortes, J., Balesar, R., Rozemuller, A. J. M., Moerland, P. D., Huitinga, I., Swaab, D. F. & Verhaagen, J. (2024). Additional file 5 of Gene-expression profiling of individuals resilient to Alzheimer's disease reveals higher expression of genes related to metallothionein and mitochondrial processes and no changes in the unfolded protein response. Figshare. https://doi.org/10.6084/m9.figshare.26712287.v1
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Nevenwerkzaamheden
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Nederlands Herseninstituut KNAW
Afdelingsmanagement -
Nederlands Herseninstituut KNAW
Leider neuroimmunologische onderzoeksgroep
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Nederlands Herseninstituut KNAW
Mekkes, N. J., Groot, M., Hoekstra, E., de Boer, A., Dagkesamanskaia, E., Bouwman, S., Wehrens, S. M. T., Herbert, M. K., Wever, D. D., Rozemuller, A., Eggen, B. J. L., Huitinga, I., & Holtman, I. R. (2024). Identification of clinical disease trajectories in neurodegenerative disorders with natural language processing. Nature medicine, 30(4), 1143-1153.